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Clinical diagnosis is a highly specialized discipline requiring both domain expertise and strict adherence to rigorous guidelines. While current AI-driven medical research predominantly focuses on knowledge graphs or natural text…

Machine Learning · Computer Science 2025-12-12 Haolin Li , Tianjie Dai , Zhe Chen , Siyuan Du , Jiangchao Yao , Ya Zhang , Yanfeng Wang

Artificial intelligence (AI) has transformed digital pathology by enabling biomarker prediction from high-resolution whole-slide images (WSIs). However, current methods are computationally inefficient, processing thousands of redundant…

The current study of cell architecture of inflammation in histopathology images commonly performed for diagnosis and research purposes excludes a lot of information available on the biopsy slide. In autoimmune diseases, major outstanding…

Image and Video Processing · Electrical Eng. & Systems 2022-10-25 Pranav Singh , Jacopo Cirrone

Training AI foundation models has emerged as a promising large-scale learning approach for addressing real-world healthcare challenges, including digital pathology. While many of these models have been developed for tasks like disease…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Junlin Guo , Siqi Lu , Can Cui , Ruining Deng , Tianyuan Yao , Zhewen Tao , Yizhe Lin , Marilyn Lionts , Quan Liu , Juming Xiong , Yu Wang , Shilin Zhao , Catie Chang , Mitchell Wilkes , Mengmeng Yin , Haichun Yang , Yuankai Huo

Advancing AI in computational pathology requires large, high-quality, and diverse datasets, yet existing public datasets are often limited in organ diversity, class coverage, or annotation quality. To bridge this gap, we introduce SPIDER…

Image and Video Processing · Electrical Eng. & Systems 2025-04-08 Dmitry Nechaev , Alexey Pchelnikov , Ekaterina Ivanova

Background: Histopathology is an important modality for the diagnosis and management of many diseases in modern healthcare, and plays a critical role in cancer care. Pathology samples can be large and require multi-site sampling, leading to…

Breast cancer is the most common cancer type in women worldwide. Early detection and appropriate treatment can significantly reduce its impact. While histopathology examinations play a vital role in rapid and accurate diagnosis, they often…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Nematollah Saeidi , Hossein Karshenas , Bijan Shoushtarian , Sepideh Hatamikia , Ramona Woitek , Amirreza Mahbod

[Purpose] The pathology is decisive for disease diagnosis, but relies heavily on the experienced pathologists. Recently, pathological artificial intelligence (PAI) is thought to improve diagnostic accuracy and efficiency. However, the high…

Image and Video Processing · Electrical Eng. & Systems 2022-05-25 Yuanqing Yang , Kai Sun , Yanhua Gao , Kuangsong Wang , Gang Yu

The emergence of large multimodal models has unlocked remarkable potential in AI, particularly in pathology. However, the lack of specialized, high-quality benchmark impeded their development and precise evaluation. To address this, we…

Computer Vision and Pattern Recognition · Computer Science 2024-03-21 Yuxuan Sun , Hao Wu , Chenglu Zhu , Sunyi Zheng , Qizi Chen , Kai Zhang , Yunlong Zhang , Dan Wan , Xiaoxiao Lan , Mengyue Zheng , Jingxiong Li , Xinheng Lyu , Tao Lin , Lin Yang

This paper aims to evaluate the suitability of current deep learning methods for clinical workflow especially by focusing on dermatology. Although deep learning methods have been attempted to get dermatologist level accuracy in several…

Computer Vision and Pattern Recognition · Computer Science 2020-03-18 Sourav Mishra , Subhajit Chaudhury , Hideaki Imaizumi , Toshihiko Yamasaki

In this paper, we consider the problem of visual representation learning for computational pathology, by exploiting large-scale image-text pairs gathered from public resources, along with the domain-specific knowledge in pathology.…

Computer Vision and Pattern Recognition · Computer Science 2024-09-17 Xiao Zhou , Xiaoman Zhang , Chaoyi Wu , Ya Zhang , Weidi Xie , Yanfeng Wang

Purpose of review: Artificial intelligence (AI) has become popular in medical applications, specifically as a clinical support tool for computer-aided diagnosis. These tools are typically employed on medical data (i.e., image, molecular…

Machine Learning · Computer Science 2022-06-08 Ahmad Chaddad , Yousef Katib , Lama Hassan

Radiology is a vital and complex component of modern clinical workflow and covers many tasks. Recently, vision-language (VL) foundation models in medicine have shown potential in processing multimodal information, offering a unified…

Computer Vision and Pattern Recognition · Computer Science 2024-09-25 Xiaohong Liu , Guoxing Yang , Yulin Luo , Jiaji Mao , Xiang Zhang , Ming Gao , Shanghang Zhang , Jun Shen , Guangyu Wang

The field of computational pathology has witnessed remarkable progress in the development of both task-specific predictive models and task-agnostic self-supervised vision encoders. However, despite the explosive growth of generative…

Computer Vision and Pattern Recognition · Computer Science 2023-12-14 Ming Y. Lu , Bowen Chen , Drew F. K. Williamson , Richard J. Chen , Kenji Ikamura , Georg Gerber , Ivy Liang , Long Phi Le , Tong Ding , Anil V Parwani , Faisal Mahmood

Foundation models are reshaping computational pathology by enabling transfer learning, where models pre-trained on vast datasets can be adapted for downstream diagnostic, prognostic, and therapeutic response tasks. Despite these advances,…

Deep unsupervised approaches are gathering increased attention for applications such as pathology detection and segmentation in medical images since they promise to alleviate the need for large labeled datasets and are more generalizable…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Ioannis Lagogiannis , Felix Meissen , Georgios Kaissis , Daniel Rueckert

While previous studies have demonstrated the potential of AI to diagnose diseases in imaging data, clinical implementation is still lagging behind. This is partly because AI models require training with large numbers of examples only…

The paper reviews the state-of-the-art of foundation models, LLMs, generative AI, information retrieval and CBIR in digital pathology

Information Retrieval · Computer Science 2024-03-20 H. R. Tizhoosh

In the cancer diagnosis pipeline, digital pathology plays an instrumental role in the identification, staging, and grading of malignant areas on biopsy tissue specimens. High resolution histology images are subject to high variance in…

Image and Video Processing · Electrical Eng. & Systems 2023-08-17 Vasileios Magoulianitis , Catherine A. Alexander , C. -C. Jay Kuo