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Remarkable strides in computational pathology have been made in the task-agnostic foundation model that advances the performance of a wide array of downstream clinical tasks. Despite the promising performance, there are still several…

Computational Pathology (CPath) is an emerging field concerned with the study of tissue pathology via computational algorithms for the processing and analysis of digitized high-resolution images of tissue slides. Recent deep learning based…

Image and Video Processing · Electrical Eng. & Systems 2021-12-20 Amina Asif , Kashif Rajpoot , David Snead , Fayyaz Minhas , Nasir Rajpoot

Recent breakthroughs in artificial intelligence through foundation models and agents have accelerated the evolution of computational pathology. Demonstrated performance gains reported across academia in benchmarking datasets in predictive…

Foundation models pretrained on large-scale datasets are revolutionizing the field of computational pathology (CPath). The generalization ability of foundation models is crucial for the success in various downstream clinical tasks. However,…

The application of new artificial intelligence (AI) discoveries is transforming healthcare research. However, the standards of reporting are variable in this still evolving field, leading to potential research waste. The aim of this work is…

Computers and Society · Computer Science 2023-01-25 Clare McGenity , Darren Treanor

This paper introduces an innovative software system for fundus image analysis that deliberately diverges from the conventional screening approach, opting not to predict specific diagnoses. Instead, our methodology mimics the diagnostic…

Computer Vision and Pattern Recognition · Computer Science 2025-01-27 Dmitry Ryabtsev , Boris Vasilyev , Sergey Shershakov

This study evaluates the generalisation capabilities of state-of-the-art histopathology foundation models on out-of-distribution multi-stain autoimmune Immunohistochemistry datasets. We compare 13 feature extractor models, including…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Amaya Gallagher-Syed , Elena Pontarini , Myles J. Lewis , Michael R. Barnes , Gregory Slabaugh

Purpose - To characterise and assess the quality of published research evaluating artificial intelligence (AI) methods for ovarian cancer diagnosis or prognosis using histopathology data. Methods - A search of PubMed, Scopus, Web of…

Image and Video Processing · Electrical Eng. & Systems 2023-06-19 Jack Breen , Katie Allen , Kieran Zucker , Pratik Adusumilli , Andy Scarsbrook , Geoff Hall , Nicolas M. Orsi , Nishant Ravikumar

Foundation models trained on large-scale pathology image corpora have demonstrated strong transfer capabilities across diverse histopathology tasks. Building on this progress, we introduce PLUTO-4, our next generation of pathology…

A Pathology report is arguably one of the most important documents in medicine containing interpretive information about the visual findings from the patient's biopsy sample. Each pathology report has a retention period of up to 20 years…

Computation and Language · Computer Science 2019-03-19 Shivam Kalra , Larry Li , Hamid R. Tizhoosh

Cytology is essential for cancer diagnostics and screening due to its minimally invasive nature. However, the development of robust deep learning models for digital cytology is challenging due to the heterogeneity in staining and…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Vedrana Ivezić , Ashwath Radhachandran , Ekaterina Redekop , Shreeram Athreya , Dongwoo Lee , Vivek Sant , Corey Arnold , William Speier

Histopathological images contain rich phenotypic information that can be used to monitor underlying mechanisms contributing to diseases progression and patient survival outcomes. Recently, deep learning has become the mainstream…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Chetan L. Srinidhi , Ozan Ciga , Anne L. Martel

Pathology foundation models have shown strong retrospective performance, but whether such systems can support clinically relevant use remains unclear. This challenge is particularly important in breast cancer, where pathological assessment…

Advancements in artificial intelligence (AI) are transforming pathology by integrat-ing large language models (LLMs) with retrieval-augmented generation (RAG) and domain-specific foundation models. This study explores the application of…

Computation and Language · Computer Science 2025-05-14 Hussien Al-Asi , Jordan P Reynolds , Shweta Agarwal , Bryan J Dangott , Aziza Nassar , Zeynettin Akkus

Large pretrained transformers are increasingly being developed as generalised foundation models which can underpin powerful task-specific artificial intelligence models. Histopathology foundation models show great promise across many tasks,…

Image and Video Processing · Electrical Eng. & Systems 2024-09-10 Jack Breen , Katie Allen , Kieran Zucker , Lucy Godson , Nicolas M. Orsi , Nishant Ravikumar

Foundation models (FMs) are transforming computational pathology by offering new ways to analyze histopathology images. However, FMs typically require weeks of training on large databases, making their creation a resource-intensive process.…

Image and Video Processing · Electrical Eng. & Systems 2026-01-27 Till Nicke , Daniela Schacherer , Jan Raphael Schäfer , Natalia Artysh , Antje Prasse , André Homeyer , Andrea Schenk , Henning Höfener , Johannes Lotz

Despite the promises of data-driven artificial intelligence (AI), little is known about how we can bridge the gulf between traditional physician-driven diagnosis and a plausible future of medicine automated by AI. Specifically, how can we…

Human-Computer Interaction · Computer Science 2021-02-12 Hongyan Gu , Jingbin Huang , Lauren Hung , Xiang 'Anthony' Chen

While machine learning is currently transforming the field of histopathology, the domain lacks a comprehensive evaluation of state-of-the-art models based on essential but complementary quality requirements beyond a mere classification…

Image and Video Processing · Electrical Eng. & Systems 2023-05-11 Maximilian Springenberg , Annika Frommholz , Markus Wenzel , Eva Weicken , Jackie Ma , Nils Strodthoff

Progress in a research field can be hard to assess, in particular when many concurrent methods are proposed in a short period of time. This is the case in digital pathology, where many foundation models have been released recently to serve…

Computer Vision and Pattern Recognition · Computer Science 2026-02-18 Pierre Marza , Leo Fillioux , Sofiène Boutaj , Kunal Mahatha , Christian Desrosiers , Pablo Piantanida , Jose Dolz , Stergios Christodoulidis , Maria Vakalopoulou

Foundation models pretrained on large-scale pathology datasets have shown promising results across various diagnostic tasks. Here, we present a systematic evaluation of transfer learning strategies for brain tumor classification using these…

Image and Video Processing · Electrical Eng. & Systems 2025-04-09 Ken Enda , Yoshitaka Oda , Zen-ichi Tanei , Kenichi Satoh , Hiroaki Motegi , Terasaka Shunsuke , Shigeru Yamaguchi , Takahiro Ogawa , Wang Lei , Masumi Tsuda , Shinya Tanaka