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Background: Single-cell RNA sequencing (scRNA-seq) is a powerful profiling technique at the single-cell resolution. Appropriate analysis of scRNA-seq data can characterize molecular heterogeneity and shed light into the underlying cellular…

Applications · Statistics 2019-08-05 Siamak Zamani Dadaneh , Paul de Figueiredo , Sing-Hoi Sze , Mingyuan Zhou , Xiaoning Qian

Recent improvements in conditional generative modeling have made it possible to generate high-quality images from language descriptions alone. We investigate whether these methods can directly address the problem of sequential…

Machine Learning · Computer Science 2023-07-11 Anurag Ajay , Yilun Du , Abhi Gupta , Joshua Tenenbaum , Tommi Jaakkola , Pulkit Agrawal

Generative AI has redefined artificial intelligence, enabling the creation of innovative content and customized solutions that drive business practices into a new era of efficiency and creativity. In this paper, we focus on diffusion…

Machine Learning · Computer Science 2024-03-21 Zihao Li , Hui Yuan , Kaixuan Huang , Chengzhuo Ni , Yinyu Ye , Minshuo Chen , Mengdi Wang

We present the Groupwise Diffusion Model (GDM), which divides data into multiple groups and diffuses one group at one time interval in the forward diffusion process. GDM generates data sequentially from one group at one time interval,…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Sangyun Lee , Gayoung Lee , Hyunsu Kim , Junho Kim , Youngjung Uh

Single-cell RNA sequencing (scRNA-seq) reveals cell heterogeneity, with cell clustering playing a key role in identifying cell types and marker genes. Recent advances, especially graph neural networks (GNNs)-based methods, have…

Genomics · Quantitative Biology 2025-10-03 Ping Xu , Zhiyuan Ning , Pengjiang Li , Wenhao Liu , Pengyang Wang , Jiaxu Cui , Yuanchun Zhou , Pengfei Wang

Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of cellular heterogeneity, enabling detailed molecular profiling at the individual cell level. However, integrating high-dimensional single-cell data into causal mediation…

Methodology · Statistics 2025-10-01 Seungjun Ahn , Li Chen , Maaike van Gerwen , Panos Roussos , Zhigang Li

Recent advances in recording technology have allowed neuroscientists to monitor activity from thousands of neurons simultaneously. Latent variable models are increasingly valuable for distilling these recordings into compact and…

Learning a categorical distribution comes with its own set of challenges. A successful approach taken by state-of-the-art works is to cast the problem in a continuous domain to take advantage of the impressive performance of the generative…

Machine Learning · Computer Science 2023-03-09 Florence Regol , Mark Coates

Recent works have shown the potential of diffusion models in computer vision and natural language processing. Apart from the classical supervised learning fields, diffusion models have also shown strong competitiveness in reinforcement…

Machine Learning · Computer Science 2023-06-09 Jifeng Hu , Yanchao Sun , Sili Huang , SiYuan Guo , Hechang Chen , Li Shen , Lichao Sun , Yi Chang , Dacheng Tao

Human organs constantly undergo anatomical changes due to a complex mix of short-term (e.g., heartbeat) and long-term (e.g., aging) factors. Evidently, prior knowledge of these factors will be beneficial when modeling their future state,…

Computer Vision and Pattern Recognition · Computer Science 2023-06-19 Jee Seok Yoon , Chenghao Zhang , Heung-Il Suk , Jia Guo , Xiaoxiao Li

The rapid advancement of generative models, such as Stable Diffusion, raises a key question: how can synthetic data from these models enhance predictive modeling? While they can generate vast amounts of datasets, only a subset meaningfully…

Machine Learning · Statistics 2025-05-09 Jialong Jiang , Wenkang Hu , Jian Huang , Yuling Jiao , Xu Liu

We propose DiffSep, a new single channel source separation method based on score-matching of a stochastic differential equation (SDE). We craft a tailored continuous time diffusion-mixing process starting from the separated sources and…

Audio and Speech Processing · Electrical Eng. & Systems 2022-11-03 Robin Scheibler , Youna Ji , Soo-Whan Chung , Jaeuk Byun , Soyeon Choe , Min-Seok Choi

We introduce a framework for joint grounded scene graph - image generation, a challenging task involving high-dimensional, multi-modal structured data. To effectively model this complex joint distribution, we adopt a factorized approach:…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Bicheng Xu , Qi Yan , Renjie Liao , Lele Wang , Leonid Sigal

We propose a probabilistic model for interpreting gene expression levels that are observed through single-cell RNA sequencing. In the model, each cell has a low-dimensional latent representation. Additional latent variables account for…

Machine Learning · Computer Science 2018-01-18 Romain Lopez , Jeffrey Regier , Michael Cole , Michael Jordan , Nir Yosef

We introduce a novel generative model, the Discrete Distribution Networks (DDN), that approximates data distribution using hierarchical discrete distributions. We posit that since the features within a network inherently capture…

Computer Vision and Pattern Recognition · Computer Science 2025-04-17 Lei Yang

Neural receivers have demonstrated strong performance in wireless communication systems. However, their effectiveness typically depends on access to large-scale, scenario-specific channel data for training, which is often difficult to…

Information Theory · Computer Science 2025-11-04 Xingyu Zhou , Le Liang , Xinjie Li , Jing Zhang , Peiwen Jiang , Xiao Li , Shi Jin

Deep neural networks have brought remarkable breakthroughs in medical image analysis. However, due to their data-hungry nature, the modest dataset sizes in medical imaging projects might be hindering their full potential. Generating…

Diffusion models have demonstrated significant promise in various generative tasks; however, they often struggle to satisfy challenging constraints. Our approach addresses this limitation by rethinking training-free loss-guided diffusion…

Machine Learning · Computer Science 2024-11-19 William Huang , Yifeng Jiang , Tom Van Wouwe , C. Karen Liu

Generative models on discrete state-spaces have a wide range of potential applications, particularly in the domain of natural sciences. In continuous state-spaces, controllable and flexible generation of samples with desired properties has…

Machine Learning · Computer Science 2025-03-27 Hunter Nisonoff , Junhao Xiong , Stephan Allenspach , Jennifer Listgarten

Stable diffusion models represent the state-of-the-art in data synthesis across diverse domains and hold transformative potential for applications in science and engineering, e.g., by facilitating the discovery of novel solutions and…

Machine Learning · Computer Science 2025-10-23 Stefano Zampini , Jacob K. Christopher , Luca Oneto , Davide Anguita , Ferdinando Fioretto