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Recent improvements in control of quantum systems make it seem feasible to finally build a quantum computer within a decade. While it has been shown that such a quantum computer can in principle solve certain small electronic structure…

Quantum Physics · Physics 2016-09-27 Bela Bauer , Dave Wecker , Andrew J. Millis , Matthew B. Hastings , M. Troyer

The quantum computation of electronic energies can break the curse of dimensionality that plagues many-particle quantum mechanics. It is for this reason that a universal quantum computer has the potential to fundamentally change…

The advent of quantum algorithms has initiated a discourse on the potential for quantum speedups for optimization problems. However, several factors still hinder a practical realization of the potential benefits. These include the lack of…

Demonstrating the practical utility of Noisy Intermediate-Scale Quantum (NISQ) hardware for recurrent tasks in Computer-Aided Drug Discovery is of paramount importance. We tackle this challenge by performing three-dimensional protein…

Quantum Physics · Physics 2025-12-12 Daniele Loco , Kisa Barkemeyer , Andre R. R. Carvalho , Jean-Philip Piquemal

Protein-ligand binding affinity is critical in drug discovery, but experimentally determining it is time-consuming and expensive. Artificial intelligence (AI) has been used to predict binding affinity, significantly accelerating this…

Emerging Technologies · Computer Science 2025-09-16 Seon-Geun Jeong , Kyeong-Hwan Moon , Won-Joo Hwang

Quantum Computing (QC) offers the potential to enhance traditional High-Performance Computing (HPC) workloads by leveraging the unique properties of quantum computers, leading to the emergence of a new paradigm: HPC-QC. While this…

Quantum computing has shown promise for solving complex optimization problems in databases, such as join ordering and index selection. Prior work often submits formulated problems directly to black-box quantum or quantum-inspired solvers…

Databases · Computer Science 2026-02-17 Hanwen Liu , Ibrahim Sabek

We use the benefits and components of classical computers every day. However, there are many types of problems which, as they grow in size, their computational complexity grows larger than classical computers will ever be able to solve.…

Research progress in quantum computing has, thus far, focused on a narrow set of application domains. Expanding the suite of quantum application domains is vital for the discovery of new software toolchains and architectural abstractions.…

Quantum computing is rapidly emerging as a promising technology for solving complex optimization problems that arise in various engineering fields. Therefore, it holds significant promise to transform the computational foundations of power…

Quantum Physics · Physics 2026-01-06 Nikolaos G. Paterakis , Petros Karamanakos , Corey O'Meara , Georgios Papafotiou

Quantum computers can in principle solve certain problems exponentially more quickly than their classical counterparts. We have not yet reached the advent of useful quantum computation, but when we do, it will affect nearly all scientific…

This PhD thesis explores the potential of quantum computing to address computational challenges in high-energy physics (HEP). As the Standard Model (SM) leaves key questions unanswered and no signs of new physics have emerged since the…

Quantum Physics · Physics 2025-12-02 Jorge J. Martínez de Lejarza

Quantum computing exploits quantum phenomena such as superposition and entanglement to realize a form of parallelism that is not available to traditional computing. It offers the potential of significant computational speed-ups in quantum…

Quantum computing (QC) has gained popularity due to its unique capabilities that are quite different from that of classical computers in terms of speed and methods of operations. This paper proposes hybrid models and methods that…

Quantum Physics · Physics 2019-11-12 Akshay Ajagekar , Travis Humble , Fengqi You

We assess the potential of quantum computing to accelerate computation of central tasks in genomics, focusing on often-neglected theoretical limitations. We discuss state-of-the-art challenges of quantum search, optimization, and machine…

Quantum Physics · Physics 2026-01-09 Aurora Maurizio , Guglielmo Mazzola

Computational models are an essential tool for the design, characterization, and discovery of novel materials. Hard computational tasks in materials science stretch the limits of existing high-performance supercomputing centers, consuming…

Quantum Physics · Physics 2024-09-20 Yuri Alexeev , Maximilian Amsler , Paul Baity , Marco Antonio Barroca , Sanzio Bassini , Torey Battelle , Daan Camps , David Casanova , Young Jai Choi , Frederic T. Chong , Charles Chung , Chris Codella , Antonio D. Corcoles , James Cruise , Alberto Di Meglio , Jonathan Dubois , Ivan Duran , Thomas Eckl , Sophia Economou , Stephan Eidenbenz , Bruce Elmegreen , Clyde Fare , Ismael Faro , Cristina Sanz Fernández , Rodrigo Neumann Barros Ferreira , Keisuke Fuji , Bryce Fuller , Laura Gagliardi , Giulia Galli , Jennifer R. Glick , Isacco Gobbi , Pranav Gokhale , Salvador de la Puente Gonzalez , Johannes Greiner , Bill Gropp , Michele Grossi , Emanuel Gull , Burns Healy , Benchen Huang , Travis S. Humble , Nobuyasu Ito , Artur F. Izmaylov , Ali Javadi-Abhari , Douglas Jennewein , Shantenu Jha , Liang Jiang , Barbara Jones , Wibe Albert de Jong , Petar Jurcevic , William Kirby , Stefan Kister , Masahiro Kitagawa , Joel Klassen , Katherine Klymko , Kwangwon Koh , Masaaki Kondo , Doga Murat Kurkcuoglu , Krzysztof Kurowski , Teodoro Laino , Ryan Landfield , Matt Leininger , Vicente Leyton-Ortega , Ang Li , Meifeng Lin , Junyu Liu , Nicolas Lorente , Andre Luckow , Simon Martiel , Francisco Martin-Fernandez , Margaret Martonosi , Claire Marvinney , Arcesio Castaneda Medina , Dirk Merten , Antonio Mezzacapo , Kristel Michielsen , Abhishek Mitra , Tushar Mittal , Kyungsun Moon , Joel Moore , Mario Motta , Young-Hye Na , Yunseong Nam , Prineha Narang , Yu-ya Ohnishi , Daniele Ottaviani , Matthew Otten , Scott Pakin , Vincent R. Pascuzzi , Ed Penault , Tomasz Piontek , Jed Pitera , Patrick Rall , Gokul Subramanian Ravi , Niall Robertson , Matteo Rossi , Piotr Rydlichowski , Hoon Ryu , Georgy Samsonidze , Mitsuhisa Sato , Nishant Saurabh , Vidushi Sharma , Kunal Sharma , Soyoung Shin , George Slessman , Mathias Steiner , Iskandar Sitdikov , In-Saeng Suh , Eric Switzer , Wei Tang , Joel Thompson , Synge Todo , Minh Tran , Dimitar Trenev , Christian Trott , Huan-Hsin Tseng , Esin Tureci , David García Valinas , Sofia Vallecorsa , Christopher Wever , Konrad Wojciechowski , Xiaodi Wu , Shinjae Yoo , Nobuyuki Yoshioka , Victor Wen-zhe Yu , Seiji Yunoki , Sergiy Zhuk , Dmitry Zubarev

Quantum computers promise polynomial or exponential speed-up in solving certain problems compared to classical computers. However, in practical use, there are currently a number of fundamental technical challenges. One of them concerns the…

Emerging Technologies · Computer Science 2024-03-20 Markus Zajac , Uta Störl

Quantum computing (QC) has experienced rapid growth in recent years with the advent of robust programming environments, readily accessible software simulators and cloud-based QC hardware platforms, and growing interest in learning how to…

Quantum Physics · Physics 2026-01-14 E. Wes Bethel , Roel Van Beeumen , Talita Perciano

Context: The emergence of quantum computing proposes a revolutionary paradigm that can radically transform numerous scientific and industrial application domains. The ability of quantum computers to scale computations beyond what the…

Quantum Physics · Physics 2024-08-07 Vlad Stirbu , Otso Kinanen , Majid Haghparast , Tommi Mikkonen

Numerical simulation of quantum systems is crucial to further our understanding of natural phenomena. Many systems of key interest and importance, in areas such as superconducting materials and quantum chemistry, are thought to be described…

Quantum Physics · Physics 2010-11-17 Katherine L Brown , William J Munro , Vivien M Kendon