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Medical Anomaly Detection (MedAD) presents a significant opportunity to enhance diagnostic accuracy using Large Multimodal Models (LMMs) to interpret and answer questions based on medical images. However, the reliance on Supervised…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Haitao Zhang , Yingying Wang , Jiaxiang Wang , Haote Xu , Hongyang Zhang , Yirong Chen , Yue Huang , Xinghao Ding

In this paper, we introduce a method for adapting the step-sizes of temporal difference (TD) learning. The performance of TD methods often depends on well chosen step-sizes, yet few algorithms have been developed for setting the step-size…

Machine Learning · Computer Science 2018-04-11 Alex Kearney , Vivek Veeriah , Jaden B. Travnik , Richard S. Sutton , Patrick M. Pilarski

Adaptive designs are commonly used in clinical and drug development studies for optimum utilization of available resources. In this article, we consider the problem of estimating the effect of the selected (better) treatment using a…

Statistics Theory · Mathematics 2023-01-24 Masihuddin , Neeraj Misra

Bayesian adaptive designs have gained popularity in all phases of clinical trials with numerous new developments in the past few decades. During the COVID-19 pandemic, the need to establish evidence for the effectiveness of vaccines,…

Methodology · Statistics 2022-03-08 Shirin Golchi

Adaptive experiment is widely adopted to estimate conditional average treatment effect (CATE) in clinical trials and many other scenarios. While the primary goal in experiment is to maximize estimation accuracy, due to the imperative of…

Methodology · Statistics 2024-02-06 Jiachun Li , Kaining Shi , David Simchi-Levi

We consider estimating the conditional average treatment effect for everyone by eliminating confounding and selection bias. Unfortunately, randomized clinical trials (RCTs) eliminate confounding but impose strict exclusion criteria that…

Machine Learning · Statistics 2021-06-15 Eric V. Strobl , Thomas A. Lasko

The regression discontinuity (RD) design is a quasi-experimental design that estimates the causal effects of a treatment by exploiting naturally occurring treatment rules. It can be applied in any context where a particular treatment or…

Estimation and inference for the Average Treatment Effect (ATE) is a cornerstone of causal inference and often serves as the foundation for developing procedures for more complicated settings. Although traditionally analyzed in a batch…

Machine Learning · Statistics 2025-02-10 Ojash Neopane , Aaditya Ramdas , Aarti Singh

Learning high quality sentence embeddings from dialogues has drawn increasing attentions as it is essential to solve a variety of dialogue-oriented tasks with low annotation cost. Annotating and gathering utterance relationships in…

Computation and Language · Computer Science 2026-04-14 Minsik Oh , Jiwei Li , Guoyin Wang

The Robust Effect Size Index (RESI) is a recently proposed standardized effect size to quantify association strength across models. However, its confidence interval construction has relied on computationally intensive bootstrap procedures.…

Methodology · Statistics 2026-01-28 Xinyu Zhang , Rachael Muscatello , Megan Jones , Blythe Corbett , Simon Vandekar

Unsupervised anomaly detection (UAD) alleviates large labeling efforts by training exclusively on unlabeled in-distribution data and detecting outliers as anomalies. Generally, the assumption prevails that large training datasets allow the…

Computer Vision and Pattern Recognition · Computer Science 2024-10-29 Felix Meissen , Johannes Getzner , Alexander Ziller , Özgün Turgut , Georgios Kaissis , Martin J. Menten , Daniel Rueckert

This study designs an adaptive experiment for efficiently estimating average treatment effects (ATEs). In each round of our adaptive experiment, an experimenter sequentially samples an experimental unit, assigns a treatment, and observes…

Methodology · Statistics 2024-06-21 Masahiro Kato , Akihiro Oga , Wataru Komatsubara , Ryo Inokuchi

Tabular anomaly detection (TAD) remains challenging due to the heterogeneity of tabular data: features lack natural relationships, vary widely in distribution and scale, and exhibit diverse types. Consequently, each TAD method makes…

Machine Learning · Computer Science 2026-05-07 Hangting Ye , He Zhao , Wei Fan , Xiaozhuang Song , Dandan Guo , Yi Chang , Hongyuan Zha

Benkeser et al. demonstrate how adjustment for baseline covariates in randomized trials can meaningfully improve precision for a variety of outcome types. Their findings build on a long history, starting in 1932 with R.A. Fisher and…

Methodology · Statistics 2026-03-03 Laura B. Balzer , Erica Cai , Lucas Godoy Garraza , Pracheta Amaranath

Level set estimation (LSE), the problem of identifying the set of input points where a function takes value above (or below) a given threshold, is important in practical applications. When the function is expensive-to-evaluate and…

Machine Learning · Statistics 2024-12-02 Yu Inatsu , Shion Takeno , Kentaro Kutsukake , Ichiro Takeuchi

In many industry settings, online controlled experimentation (A/B test) has been broadly adopted as the gold standard to measure product or feature impacts. Most research has primarily focused on user engagement type metrics, specifically…

Methodology · Statistics 2020-10-30 Weinan Wang , Xi Zhang

Targeted Radionuclide Therapy (TRT) is a modern strategy in radiation oncology that aims to administer a potent radiation dose specifically to cancer cells using cancer-targeting radiopharmaceuticals. Accurate radiation dose estimation…

Medical Physics · Physics 2025-09-15 Jing Zhang , Alexandre Bousse , Chi-Hieu Pham , Kuangyu Shi , Julien Bert

Randomized controlled trials (RCTs) are widely regarded as the gold standard for causal inference in biomedical research. For instance, when estimating the average treatment effect on the treated (ATT), a doubly robust estimation procedure…

Methodology · Statistics 2025-09-26 Chi-Shian Dai , Chao Ying , Yang Ning , Jiwei Zhao

Dataset distillation compresses a large dataset into a small synthetic subset that retains essential information. Existing methods assume that all samples are perfectly labeled, limiting their real-world applications where incorrect labels…

Computer Vision and Pattern Recognition · Computer Science 2025-02-10 Zhuojie Wu , Yanbin Liu , Xin Shen , Xiaofeng Cao , Xin Yu

Background: Under competing risks, the commonly used sub-distribution hazard ratio (SHR) is not easy to interpret clinically and is valid only under the proportional sub-distribution hazard (SDH) assumption. This paper introduces an…

Methodology · Statistics 2020-10-06 Jingjing Lyu , Yawen Hou , Zheng Chen
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