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The Segment Anything Model (SAM) demonstrates impressive zero-shot segmentation ability on natural images but encounters difficulties in medical imaging due to domain shifts, anatomical variability, and its reliance on user-provided…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Yingzhen Hu , Yiheng Zhong , Ruobing Li , Yingxue Su , Jiabao An , Feilong Tang , Jionglong Su , Imran Razzak

Medical image segmentation is a critical component in clinical practice, facilitating accurate diagnosis, treatment planning, and disease monitoring. However, existing methods, often tailored to specific modalities or disease types, lack…

Image and Video Processing · Electrical Eng. & Systems 2024-04-02 Jun Ma , Yuting He , Feifei Li , Lin Han , Chenyu You , Bo Wang

Melanoma segmentation in Whole Slide Images (WSIs) is useful for prognosis and the measurement of crucial prognostic factors such as Breslow depth and primary invasive tumor size. In this paper, we present a novel approach that uses the…

Computer Vision and Pattern Recognition · Computer Science 2024-10-04 Qingyuan Liu , Avideh Zakhor

In the evolving landscape of computer vision, foundation models have emerged as pivotal tools, exhibiting exceptional adaptability to a myriad of tasks. Among these, the Segment Anything Model (SAM) by Meta AI has distinguished itself in…

Computer Vision and Pattern Recognition · Computer Science 2024-05-02 Bo Li , Haoke Xiao , Lv Tang

The emerging scale segmentation model, Segment Anything (SAM), exhibits impressive capabilities in zero-shot segmentation for natural images. However, when applied to medical images, SAM suffers from noticeable performance drop. To make SAM…

Computer Vision and Pattern Recognition · Computer Science 2023-06-27 Xinrong Hu , Xiaowei Xu , Yiyu Shi

The Segment Anything Model (SAM) represents a significant breakthrough into foundation models for computer vision, providing a large-scale image segmentation model. However, despite SAM's zero-shot performance, its segmentation masks lack…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Xianjie Liu , Keren Fu , Yao Jiang , Qijun Zhao

Multimodal image fusion and semantic segmentation are critical for autonomous driving. Despite advancements, current models often struggle with segmenting densely packed elements due to a lack of comprehensive fusion features for guidance…

Computer Vision and Pattern Recognition · Computer Science 2025-06-25 Daixun Li , Weiying Xie , Mingxiang Cao , Yunke Wang , Yusi Zhang , Leyuan Fang , Yunsong Li , Chang Xu

Foundation models like the Segment Anything Model (SAM) excel in zero-shot segmentation for natural images but struggle with medical image segmentation due to differences in texture, contrast, and noise. Annotating medical images is costly…

Image and Video Processing · Electrical Eng. & Systems 2025-04-14 Sourya Sengupta , Satrajit Chakrabarty , Keerthi Sravan Ravi , Gopal Avinash , Ravi Soni

Medical image registration is a fundamental task in medical image analysis, aiming to establish spatial correspondences between paired images. However, existing unsupervised deformable registration methods rely solely on intensity-based…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Hao Xu , Tengfei Xue , Jianan Fan , Dongnan Liu , Yuqian Chen , Fan Zhang , Carl-Fredrik Westin , Ron Kikinis , Lauren J. O'Donnell , Weidong Cai

The Segment Anything Model (SAM) exhibits promise in generic object segmentation and offers potential for various applications. Existing methods have applied SAM to surgical instrument segmentation (SIS) by tuning SAM-based frameworks with…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Wenxi Yue , Jing Zhang , Kun Hu , Qiuxia Wu , Zongyuan Ge , Yong Xia , Jiebo Luo , Zhiyong Wang

While the Segment Anything Model (SAM) excels in semantic segmentation for general-purpose images, its performance significantly deteriorates when applied to medical images, primarily attributable to insufficient representation of medical…

Computer Vision and Pattern Recognition · Computer Science 2023-11-07 Yiming Zhang , Tianang Leng , Kun Han , Xiaohui Xie

Large foundation models, known for their strong zero-shot generalization, have excelled in visual and language applications. However, applying them to medical image segmentation, a domain with diverse imaging types and target labels,…

Image and Video Processing · Electrical Eng. & Systems 2024-04-18 Junde Wu , Jiayuan Zhu , Yueming Jin , Min Xu

With the development of Deep Neural Networks (DNNs), many efforts have been made to handle medical image segmentation. Traditional methods such as nnUNet train specific segmentation models on the individual datasets. Plenty of recent…

Computer Vision and Pattern Recognition · Computer Science 2024-07-12 Xiaobao Wei , Jiajun Cao , Yizhu Jin , Ming Lu , Guangyu Wang , Shanghang Zhang

The performance of image segmentation models has historically been constrained by the high cost of collecting large-scale annotated data. The Segment Anything Model (SAM) alleviates this original problem through a promptable,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Miguel Espinosa , Chenhongyi Yang , Linus Ericsson , Steven McDonagh , Elliot J. Crowley

Although SAM-based single-source domain generalization models for medical image segmentation can mitigate the impact of domain shift on the model in cross-domain scenarios, these models still face two major challenges. First, the…

Computer Vision and Pattern Recognition · Computer Science 2025-07-24 Huanli Zhuo , Leilei Ma , Haifeng Zhao , Shiwei Zhou , Dengdi Sun , Yanping Fu

The universality of deep neural networks across different modalities and their generalization capabilities to unseen domains play an essential role in medical image segmentation. The recent segment anything model (SAM) has demonstrated…

Image and Video Processing · Electrical Eng. & Systems 2025-07-02 Qing Xu , Jiaxuan Li , Xiangjian He , Chenxin Li , Fiseha B. Tesem , Wenting Duan , Zhen Chen , Rong Qu , Jonathan M. Garibaldi , Chang Wen Chen

Automatic segmentation of medical images is crucial in modern clinical workflows. The Segment Anything Model (SAM) has emerged as a versatile tool for image segmentation without specific domain training, but it requires human prompts and…

Computer Vision and Pattern Recognition · Computer Science 2024-05-16 Yunxiang Li , Bowen Jing , Zihan Li , Jing Wang , You Zhang

Pre-trained on a large and diverse dataset, the segment anything model (SAM) is the first promptable foundation model in computer vision aiming at object segmentation tasks. In this work, we evaluate SAM for the task of nuclear instance…

Image and Video Processing · Electrical Eng. & Systems 2024-01-26 Kesi Xu , Lea Goetz , Nasir Rajpoot

The interactive segmentation task consists in the creation of object segmentation masks based on user interactions. The most common way to guide a model towards producing a correct segmentation consists in clicks on the object and…

Computer Vision and Pattern Recognition · Computer Science 2024-04-15 Robin Schön , Julian Lorenz , Katja Ludwig , Rainer Lienhart

Nucleus segmentation is an important analysis task in digital pathology. However, methods for automatic segmentation often struggle with new data from a different distribution, requiring users to manually annotate nuclei and retrain…

Image and Video Processing · Electrical Eng. & Systems 2025-06-03 Titus Griebel , Anwai Archit , Constantin Pape