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In this work, we introduce Brain Latent Progression (BrLP), a novel spatiotemporal disease progression model based on latent diffusion. BrLP is designed to predict the evolution of diseases at the individual level on 3D brain MRIs. Existing…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Lemuel Puglisi , Daniel C. Alexander , Daniele Ravì

Pre-trained diffusion models provide rich latent features across U-Net levels and are emerging as powerful vision backbones. While prior works such as Marigold and Lotus repurpose diffusion priors for dense geometric perception tasks such…

Computer Vision and Pattern Recognition · Computer Science 2026-03-16 Shuang Liang , Jing He , Chuanmeizhi Wang , Lejun Liao , Guo Zhang , Yingcong Chen , Yuan Yuan

For predicting cancer survival outcomes, standard approaches in clinical research are often based on two main modalities: pathology images for observing cell morphology features, and genomic (e.g., bulk RNA-seq) for quantifying gene…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Hongxiao Wang , Yang Yang , Zhuo Zhao , Pengfei Gu , Nishchal Sapkota , Danny Z. Chen

Spatial transcriptomics allows researchers to visualize and analyze gene expression within the precise location of tissues or cells. It provides spatially resolved gene expression data but often lacks cellular resolution, necessitating cell…

Quantitative Methods · Quantitative Biology 2025-10-27 Jiasen Zhang , Xi Qiao , Liangliang Zhang , Weihong Guo

Denoising diffusion models (DDM) have gained recent traction in medical image translation given improved training stability over adversarial models. DDMs learn a multi-step denoising transformation to progressively map random Gaussian-noise…

Image and Video Processing · Electrical Eng. & Systems 2024-05-14 Fuat Arslan , Bilal Kabas , Onat Dalmaz , Muzaffer Ozbey , Tolga Çukur

Metastasis is the leading cause of cancer-related mortality, yet most predictive models rely on shallow architectures and neglect patient-specific regulatory mechanisms. Here, we integrate classical machine learning and deep learning to…

Other Quantitative Biology · Quantitative Biology 2025-12-29 Jiwei Fu , Chunyu Yang

Many imaging techniques for biological systems -- like fixation of cells coupled with fluorescence microscopy -- provide sharp spatial resolution in reporting locations of individuals at a single moment in time but also destroy the dynamics…

Subcellular Processes · Quantitative Biology 2024-05-15 Christopher E. Miles , Scott A. McKinley , Fangyuan Ding , Richard B. Lehoucq

Data-driven cell tracking and segmentation methods in biomedical imaging require diverse and information-rich training data. In cases where the number of training samples is limited, synthetic computer-generated data sets can be used to…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 David Wiesner , Julian Suk , Sven Dummer , Tereza Nečasová , Vladimír Ulman , David Svoboda , Jelmer M. Wolterink

Bayesian models based on Gaussian processes (GPs) offer a flexible framework to predict spatially distributed variables with uncertainty. But the use of nonstationary priors, often necessary for capturing complex spatial patterns, makes…

Machine Learning · Statistics 2025-06-02 Gabriel V Cardoso , Mike Pereira

Spatial transcriptomics (ST) provides spatially resolved measurements of gene expression, enabling characterization of the molecular landscape of human tissue beyond histological assessment as well as localized readouts that can be aligned…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Konstantin Hemker , Andrew H. Song , Cristina Almagro-Pérez , Guillaume Jaume , Sophia J. Wagner , Anurag Vaidya , Nikola Simidjievski , Mateja Jamnik , Faisal Mahmood

Speech super-resolution (SR) is the task that restores high-resolution speech from low-resolution input. Existing models employ simulated data and constrained experimental settings, which limit generalization to real-world SR. Predictive…

Audio and Speech Processing · Electrical Eng. & Systems 2024-01-26 Heming Wang , Eric W. Healy , DeLiang Wang

Recently, there has been discussions on the ill-posed nature of super-resolution that multiple possible reconstructions exist for a given low-resolution image. Using normalizing flows, SRflow[23] achieves state-of-the-art perceptual quality…

Image and Video Processing · Electrical Eng. & Systems 2021-08-20 Sieun Park , Eunho Lee

Self-supervised pretraining from static structures of drug-like compounds and proteins enable powerful learned feature representations. Learned features demonstrate state of the art performance on a range of predictive tasks including…

Biomolecules · Quantitative Biology 2025-09-12 Derek Jones , Yue Yang , Felice C. Lightstone , Niema Moshiri , Jonathan E. Allen , Tajana S. Rosing

We study the asymptotic behaviors of stochastic cell fate decision between proliferation and differentiation. We propose a model of a self-replicating Langevin system, where cells choose their fate (i.e. proliferation or differentiation)…

Statistical Mechanics · Physics 2017-07-12 Hiroki Yamaguchi , Kyogo Kawaguchi , Takahiro Sagawa

Traditional spectral energy distribution (SED) fitting techniques face uncertainties due to assumptions in star formation histories and dust attenuation curves. We propose an advanced machine learning-based approach that enhances…

Instrumentation and Methods for Astrophysics · Physics 2024-02-13 Sankalp Gilda

We study the problem of predicting the future, though only in the probabilistic sense of estimating a future state of a time-varying probability distribution. This is not only an interesting academic problem, but solving this extrapolation…

Machine Learning · Statistics 2014-11-21 Christoph H. Lampert

Exploiting past 3D LiDAR scans to predict future point clouds is a promising method for autonomous mobile systems to realize foresighted state estimation, collision avoidance, and planning. In this paper, we address the problem of…

Computer Vision and Pattern Recognition · Computer Science 2021-10-19 Benedikt Mersch , Xieyuanli Chen , Jens Behley , Cyrill Stachniss

Predicting future frames for robotic surgical video is an interesting, important yet extremely challenging problem, given that the operative tasks may have complex dynamics. Existing approaches on future prediction of natural videos were…

Computer Vision and Pattern Recognition · Computer Science 2021-03-19 Xiaojie Gao , Yueming Jin , Zixu Zhao , Qi Dou , Pheng-Ann Heng

Score-based generative models (SGMs) are powerful tools to sample from complex data distributions. Their underlying idea is to (i) run a forward process for time $T_1$ by adding noise to the data, (ii) estimate its score function, and (iii)…

Machine Learning · Computer Science 2024-06-06 Francesco Pedrotti , Jan Maas , Marco Mondelli

Radiation therapy serves as an effective and standard method for cancer treatment. Excellent radiation therapy plans always rely on high-quality dose distribution maps obtained through repeated trial and error by experienced experts.…

Image and Video Processing · Electrical Eng. & Systems 2023-12-12 Linjie Fu , Xia Li , Xiuding Cai , Yingkai Wang , Xueyao Wang , Yu Yao , Yali Shen
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