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Advancement in mid-infrared (MIR) technology has led to promising biomedical applications of MIR spectroscopy, such as liquid biopsy or breath diagnosis. On the contrary, MIR microscopy has been rarely used for live biological samples in an…
Implicit neural representations (INRs) have been successfully used to compress a variety of 3D surface representations such as Signed Distance Functions (SDFs), voxel grids, and also other forms of structured data such as images, videos,…
Image steganography plays a vital role in securing secret data by embedding it in the cover images. Usually, these images are communicated in a compressed format. Existing techniques achieve this but have low embedding capacity. Enhancing…
The distance metric plays an important role in nearest neighbor (NN) classification. Usually the Euclidean distance metric is assumed or a Mahalanobis distance metric is optimized to improve the NN performance. In this paper, we study the…
We present a comprehensive new framework for handling biologically accurate models of molecular evolution. This model provides a systematic framework for studying models of molecular evolution that implement heterogeneous rates,…
Recent advances in bioimaging have provided scientists a superior high spatial-temporal resolution to observe dynamics of living cells as 3D volumetric videos. Unfortunately, the 3D biomedical video analysis is lagging, impeded by resource…
Structured illumination microscopy (SIM) achieves doubled spatial resolution by exciting the specimen with a high-contrast, high-frequency sinusoidal pattern. Such an excitation pattern can be generated by interference between multiple…
Many important applications, including signal reconstruction, parameter estimation, and signal processing in a compressed domain, rely on a low-dimensional representation of the dataset that preserves {\em all} pairwise distances between…
Model-driven analysis of biophysical phenomena is gaining increased attention and utility for medical imaging applications. In magnetic resonance imaging (MRI), the availability of well-established models for describing the relations…
Near-infrared (NIR) hyperspectral imaging is widely used to reveal morphological and chemical information. However, conventional spectral imagers usually rely on costly focal plane arrays and suffer from data redundancy and inefficiencies…
With exponential growth in the use of digital image data, the need for efficient transmission methods has become imperative. Traditional image compression techniques often sacrifice image fidelity for reduced file sizes, challenging…
Cryogenic electron microscopy (Cryo-EM) has become an essential tool for capturing high-resolution biological structures. Despite its advantage in visualizations, the large storage size of Cryo-EM data file poses significant challenges for…
Accurate delineation of individual cells in microscopy videos is essential for studying cellular dynamics, yet separating touching or overlapping instances remains a persistent challenge. Although foundation-model for segmentation such as…
Neural networks that map 3D coordinates to signed distance function (SDF) or occupancy values have enabled high-fidelity implicit representations of object shape. This paper develops a new shape model that allows synthesizing novel distance…
A single-particle cryo-electron microscopy (cryo-EM) measurement, called a micrograph, consists of multiple two-dimensional tomographic projections of a three-dimensional (3-D) molecular structure at unknown locations, taken under unknown…
This paper investigates the conformal isometry hypothesis as a potential explanation for the hexagonal periodic patterns in grid cell response maps. We posit that grid cell activities form a high-dimensional vector in neural space, encoding…
The normalized information distance is a universal distance measure for objects of all kinds. It is based on Kolmogorov complexity and thus uncomputable, but there are ways to utilize it. First, compression algorithms can be used to…
The reconstruction of high-quality shape geometry is crucial for developing freehand 3D ultrasound imaging. However, the shape reconstruction of multi-view ultrasound data remains challenging due to the elevation distortion caused by thick…
We propose a new embedding method for a single vector and for a pair of vectors. This embedding method enables: a) efficient classification and regression of functions of single vectors; b) efficient approximation of distance functions; and…
Accurate segmentation of 3-D cell nuclei in microscopy images is essential for the study of nuclear organization, gene expression, and cell morphodynamics. Current image segmentation methods are challenged by the complexity and variability…