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In the scanning transmission electron microscope, both phase imaging of beam-sensitive materials and characterisation of a material's functional properties using in-situ experiments are becoming more widely available. As the practicable…

Materials Science · Physics 2024-09-20 Julie Marie Bekkevold , Jonathan J. P. Peters , Ryo Ishikawa , Naoya Shibata , Lewys Jones

Label-free tomographic microscopy offers a compelling means to visualize three-dimensional (3D) refractive index (RI) distributions from two-dimensional (2D) intensity measurements. However, limited forward-model accuracy and the ill-posed…

Optics · Physics 2025-02-27 Delong Yang , Shaohui Zhang , Jiasong Sun , Chao Zuo , Qun Hao

X-ray Ptychography is an advanced computational microscopy technique which is delivering exceptionally detailed quantitative imaging of biological and nanotechnology specimens. However coarse parametrisation in propagation distance,…

Image and Video Processing · Electrical Eng. & Systems 2021-10-20 Francesco Guzzi , George Kourousias , Fulvio Billè , Roberto Pugliese , Alessandra Gianoncelli , Sergio Carrato

One of the most prominent challenges in the field of diffractive imaging is the phase retrieval (PR) problem: In order to reconstruct an object from its diffraction pattern, the inverse Fourier transform must be computed. This is only…

Image and Video Processing · Electrical Eng. & Systems 2022-05-06 Simon Welker , Tal Peer , Henry N. Chapman , Timo Gerkmann

Digital holography is one of the most widely used label-free microscopy techniques in biomedical imaging. Recovery of the missing phase information of a hologram is an important step in holographic image reconstruction. Here we demonstrate…

Image and Video Processing · Electrical Eng. & Systems 2021-05-28 Luzhe Huang , Tairan Liu , Xilin Yang , Yi Luo , Yair Rivenson , Aydogan Ozcan

In this work, we present and investigate the novel blind inverse problem of position-blind ptychography, i.e., ptychographic phase retrieval without any knowledge of scan positions, which then must be recovered jointly with the image. The…

Image and Video Processing · Electrical Eng. & Systems 2026-03-18 Simon Welker , Lorenz Kuger , Tim Roith , Berthy Feng , Martin Burger , Timo Gerkmann , Henry Chapman

Ptychography is a lensless, computational imaging method that utilises diffraction patterns to determine the amplitude and phase of an object. In transmission ptychography, the diffraction patterns are recorded by a detector positioned…

Image and Video Processing · Electrical Eng. & Systems 2023-01-04 Kira A. M. Maathuis , Jacob Seifert , Allard P. Mosk

Ptychography is a computational imaging technique that has risen in popularity in the x-ray and electron microscopy communities in the past half decade. One of the reasons for this success is the development of new high performance electron…

Computational Physics · Physics 2023-09-26 Anton Gladyshev , Thomas C. Pekin , Marcel Schloz , Benedikt Haas , Johannes Müller , Christoph T. Koch

CDI is a lensless imaging technique that enables atomic-resolution imaging of non-crystalline specimens and their dynamics. However, its broader implementation has been hindered by the instability and ill-posedness of its reconstruction…

Optics · Physics 2025-12-11 Zhe Hu , Zisheng Yao , Yuhe Zhang , Pablo Villanueva-Perez

Background: Photoacoustic Microscopy (PAM) integrates optical and acoustic imaging, offering enhanced penetration depth for detecting optical-absorbing components in tissues. Nonetheless, challenges arise in scanning large areas with high…

Medical Physics · Physics 2023-12-15 Irem Loc , Mehmet Burcin Unlu

Ptychography is a lensless imaging technique, which considers reconstruction from a set of far-field diffraction patterns obtained by illuminating small overlapping regions of the specimen. In many cases, a distribution of light inside the…

Numerical Analysis · Mathematics 2022-10-05 Frank Filbir , Oleh Melnyk

We describe and demonstrate an optimization-based x-ray image reconstruction framework called Adorym. Our framework provides a generic forward model, allowing one code framework to be used for a wide range of imaging methods ranging from…

Image and Video Processing · Electrical Eng. & Systems 2021-04-07 Ming Du , Saugat Kandel , Junjing Deng , Xiaojing Huang , Arnaud Demortiere , Tuan Tu Nguyen , Remi Tucoulou , Vincent De Andrade , Qiaoling Jin , Chris Jacobsen

Ptychography is a promising phase retrieval technique for visible light, X-ray and electron beams. Conventional ptychography reconstructs the amplitude and phase of an object light from a set of the diffraction intensity patterns obtained…

As a promising lensless imaging method for distance objects, intensity interferometry imaging (III) had been suffering from the unreliable phase retrieval process, hindering the development of III for decades. Recently, the introduction of…

Optics · Physics 2021-02-11 Yuchen He , Yuan Yuan , Hui Chen , Huaibin Zheng , Jianbin Liu , Zhuo Xu

We present an end-to-end automated workflow that uses large-scale remote compute resources and an embedded GPU platform at the edge to enable AI/ML-accelerated real-time analysis of data collected for x-ray ptychography. Ptychography is a…

Computer Vision and Pattern Recognition · Computer Science 2023-04-11 Anakha V Babu , Tekin Bicer , Saugat Kandel , Tao Zhou , Daniel J. Ching , Steven Henke , Siniša Veseli , Ryan Chard , Antonino Miceli , Mathew Joseph Cherukara

Photoacoustic imaging (PAI) is a non-invasive imaging modality that detects the ultrasound signal generated from tissue with light excitation. Photoacoustic computed tomography (PACT) uses unfocused large-area light to illuminate the target…

Image and Video Processing · Electrical Eng. & Systems 2022-04-13 Hengrong Lan , Jiali Gong , Fei Gao

While continuous diffusion models have achieved remarkable success, discrete diffusion offers a unified framework for jointly modeling text and images. Beyond unification, discrete diffusion provides faster inference, finer control, and…

Three-dimensional (3D) refractive index (RI) tomography offers label-free, quantitative volumetric imaging but faces limitations due to optical aberrations, limited resolution, and the computational complexity inherent to existing…

Different studies in x-ray microscopy have arrived at conflicting conclusions about the dose efficiency of imaging modes involving the recording of intensity distributions in the near (Fresnel regime) or far (Fraunhofer regime) field…

Image and Video Processing · Electrical Eng. & Systems 2020-12-23 Ming Du , Doga Gursoy , Chris Jacobsen

Coherent microscopy techniques provide an unparalleled multi-scale view of materials across scientific and technological fields, from structural materials to quantum devices, from integrated circuits to biological cells. Driven by the…