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Efficient sampling from the Boltzmann distribution given its energy function is a key challenge for modeling complex physical systems such as molecules. Boltzmann Generators address this problem by leveraging continuous normalizing flows to…

Machine Learning · Computer Science 2025-10-17 Rishal Aggarwal , Jacky Chen , Nicholas M. Boffi , David Ryan Koes

Transformer-based Diffusion Probabilistic Models (DPMs) have shown more potential than CNN-based DPMs, yet their extensive computational requirements hinder widespread practical applications. To reduce the computation budget of…

Computer Vision and Pattern Recognition · Computer Science 2024-11-01 Xinwang Chen , Ning Liu , Yichen Zhu , Feifei Feng , Jian Tang

Recent advancements in diffusion models have significantly advanced text-to-image generation, yet global text prompts alone remain insufficient for achieving fine-grained control over individual entities within an image. To address this…

Computer Vision and Pattern Recognition · Computer Science 2025-01-31 Hong Zhang , Zhongjie Duan , Xingjun Wang , Yingda Chen , Yu Zhang

Energy-based models (EBMs) offer a flexible framework for probabilistic modelling across various data domains. However, training EBMs on data in discrete or mixed state spaces poses significant challenges due to the lack of robust and fast…

Machine Learning · Statistics 2024-12-03 Tobias Schröder , Zijing Ou , Yingzhen Li , Andrew B. Duncan

We review Boltzmann machines and energy-based models. A Boltzmann machine defines a probability distribution over binary-valued patterns. One can learn parameters of a Boltzmann machine via gradient based approaches in a way that log…

Neural and Evolutionary Computing · Computer Science 2019-01-21 Takayuki Osogami

Diffusion models have achieved state-of-the-art results in generative modelling but remain computationally intensive at inference time, often requiring thousands of discretization steps. To this end, we propose Sig-DEG (Signature-based…

Machine Learning · Computer Science 2025-08-26 Lei Jiang , Wen Ge , Niels Cariou-Kotlarek , Mingxuan Yi , Po-Yu Chen , Lingyi Yang , Francois Buet-Golfouse , Gaurav Mittal , Hao Ni

Molecules in equilibrium follow a Boltzmann distribution, making the underlying energy landscape a physically grounded modeling objective. However, such landscapes are difficult to learn from data and, once learned, hard to sample from.…

Machine Learning · Computer Science 2026-05-19 Christoph Griesbacher , Lea Bogensperger , Andreas Habring , Thomas Pock

Sampling from unnormalized target distributions, e.g.\ Boltzmann distributions $\mu_{\text{target}}(x) \propto \exp(-E(x)/T)$, is fundamental to many scientific applications yet computationally challenging due to complex, high-dimensional…

Machine Learning · Statistics 2026-04-22 Niclas Dern , Lennart Redl , Sebastian Pfister , Marcel Kollovieh , David Lüdke , Stephan Günnemann

We present energy-based generative flow networks (EB-GFN), a novel probabilistic modeling algorithm for high-dimensional discrete data. Building upon the theory of generative flow networks (GFlowNets), we model the generation process by a…

Machine Learning · Computer Science 2022-06-10 Dinghuai Zhang , Nikolay Malkin , Zhen Liu , Alexandra Volokhova , Aaron Courville , Yoshua Bengio

Personalized electrocardiogram (ECG) generation is to simulate a patient's ECG digital twins tailored to specific conditions. It has the potential to transform traditional healthcare into a more accurate individualized paradigm, while…

Machine Learning · Computer Science 2026-02-03 Yongfan Lai , Bo Liu , Xinyan Guan , Qinghao Zhao , Hongyan Li , Shenda Hong

To simulate non-equilibrium compressible flows, a new discrete Boltzmann model, discrete Ellipsoidal Statistical(ES)-BGK model, is proposed. Compared with the original discrete BGK model, the discrete ES-BGK has a flexible Prandtl number.…

Fluid Dynamics · Physics 2018-03-08 Yudong Zhang , Aiguo Xu , Guangcai Zhang , Zhihua Chen , Pei Wang

This paper introduces DreamDiffusion, a novel method for generating high-quality images directly from brain electroencephalogram (EEG) signals, without the need to translate thoughts into text. DreamDiffusion leverages pre-trained…

Computer Vision and Pattern Recognition · Computer Science 2023-07-03 Yunpeng Bai , Xintao Wang , Yan-pei Cao , Yixiao Ge , Chun Yuan , Ying Shan

Diffusion bridge models have shown great promise in image restoration by explicitly connecting clean and degraded image distributions. However, they often rely on complex and high-cost trajectories, which limit both sampling efficiency and…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Jinhui Hou , Zhiyu Zhu , Junhui Hou

While energy-based models (EBMs) exhibit a number of desirable properties, training and sampling on high-dimensional datasets remains challenging. Inspired by recent progress on diffusion probabilistic models, we present a diffusion…

Machine Learning · Computer Science 2021-03-30 Ruiqi Gao , Yang Song , Ben Poole , Ying Nian Wu , Diederik P. Kingma

Diffusion Transformers (DiT) have demonstrated remarkable generative capabilities but remain highly computationally expensive. Previous acceleration methods, such as pruning and distillation, typically rely on a fixed computational…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Jiangshan Wang , Zeqiang Lai , Jiarui Chen , Jiayi Guo , Hang Guo , Xiu Li , Xiangyu Yue , Chunchao Guo

Predicting the effect of amino acid mutations on enzyme thermodynamic stability (DDG) is fundamental to protein engineering and drug design. While recent deep learning approaches have shown promise, they often process sequence and structure…

Machine Learning · Computer Science 2025-11-10 Abigail Lin

Diffusion-based generative models learn to iteratively transfer unstructured noise to a complex target distribution as opposed to Generative Adversarial Networks (GANs) or the decoder of Variational Autoencoders (VAEs) which produce samples…

Machine Learning · Computer Science 2022-10-26 Sarthak Mittal , Guillaume Lajoie , Stefan Bauer , Arash Mehrjou

Generative models for 3D molecular conformations must respect Euclidean symmetries and concentrate probability mass on thermodynamically favorable, mechanically stable structures. However, E(3)-equivariant diffusion models often reproduce…

Machine Learning · Computer Science 2026-01-30 Yunyang Li , Lin Huang , Luojia Xia , Wenhe Zhang , Mark Gerstein

Model-free reinforcement learning has emerged as a powerful method for developing robust robot control policies capable of navigating through complex and unstructured terrains. The effectiveness of these methods hinges on two essential…

Robotics · Computer Science 2024-10-15 Youwei Yu , Junhong Xu , Lantao Liu

Diffusion models (DMs) are a class of generative machine learning methods that sample a target distribution by transforming samples of a trivial (often Gaussian) distribution using a learned stochastic differential equation. In standard…

Statistical Mechanics · Physics 2024-08-15 Luke Causer , Grant M. Rotskoff , Juan P. Garrahan