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Background Advancements in Large Language Models (LLMs) hold transformative potential in healthcare, however, recent work has raised concern about the tendency of these models to produce outputs that display racial or gender biases.…

Forecasting the short-term spread of an ongoing disease outbreak is a formidable challenge due to the complexity of contributing factors, some of which can be characterized through interlinked, multi-modality variables such as…

Machine Learning · Computer Science 2024-04-11 Hongru Du , Jianan Zhao , Yang Zhao , Shaochong Xu , Xihong Lin , Yiran Chen , Lauren M. Gardner , Hao Frank Yang

Recent advances in pre-trained language modeling have facilitated significant progress across various natural language processing (NLP) tasks. Word masking during model training constitutes a pivotal component of language modeling in…

Computation and Language · Computer Science 2024-02-27 Anas Belfathi , Ygor Gallina , Nicolas Hernandez , Richard Dufour , Laura Monceaux

This paper demonstrates that language models are strong structure-based protein designers. We present LM-Design, a generic approach to reprogramming sequence-based protein language models (pLMs), that have learned massive sequential…

Machine Learning · Computer Science 2023-02-10 Zaixiang Zheng , Yifan Deng , Dongyu Xue , Yi Zhou , Fei YE , Quanquan Gu

In our study, we propose a self-supervised neural topic model (NTM) that combines the power of NTMs and regularized self-supervised learning methods to improve performance. NTMs use neural networks to learn latent topics hidden behind the…

Machine Learning · Computer Science 2025-02-27 Weiran Xu , Kengo Hirami , Koji Eguchi

Large language models (LLMs) process and predict sequences containing text to answer questions, and address tasks including document summarization, providing recommendations, writing software and solving quantitative problems. We provide a…

Numerical Analysis · Mathematics 2026-02-02 Ricardo Baptista , Andrew Stuart , Son Tran

The exponential growth of data generated on the Internet in the current information age is a driving force for the digital economy. Extraction of information is the major value in an accumulated big data. Big data dependency on statistical…

Despite rapid adoption of autoregressive large language models, smaller text encoders still play an important role in text understanding tasks that require rich contextualized representations. Negation is an important semantic function that…

Computation and Language · Computer Science 2025-07-18 Thinh Hung Truong , Karin Verspoor , Trevor Cohn , Timothy Baldwin

Large Language Models (LLM) continue to demonstrate their utility in a variety of emergent capabilities in different fields. An area that could benefit from effective language understanding in cybersecurity is the analysis of log files.…

Networking and Internet Architecture · Computer Science 2023-11-27 Egil Karlsen , Xiao Luo , Nur Zincir-Heywood , Malcolm Heywood

Large language models (LLMs) offer new opportunities for automated data extraction and property prediction across materials science, yet their use in superconductivity research remains limited. Here we construct a large experimental…

Materials Science · Physics 2025-12-12 Suman Itani , Yibo Zhang , Ranjit Itani , Jiadong Zang

Artificial intelligence (AI) technology has advanced rapidly in recent years, with large language models (LLMs) emerging as a significant breakthrough. LLMs are increasingly making an impact across various industries, with the medical field…

Artificial Intelligence · Computer Science 2025-09-24 Zhiyu Kan , Wensheng Gan , Zhenlian Qi , Philip S. Yu

Purpose: This study aimed to enhance protein sequence classification using natural language processing (NLP) techniques while addressing the impact of sequence similarity on model performance. We compared various machine learning and deep…

Quantitative Methods · Quantitative Biology 2025-05-26 Huma Perveen , Julie Weeds

We introduce a pioneering methodology for boosting large language models in the domain of protein representation learning. Our primary contribution lies in the refinement process for correlating the over-reliance on co-evolution knowledge,…

Artificial Intelligence · Computer Science 2024-12-05 Yaoyao Xu , Xinjian Zhao , Xiaozhuang Song , Benyou Wang , Tianshu Yu

The aim of this paper is to evaluate whether large language models trained on multi-choice question data can be used to discriminate between medical subjects. This is an important and challenging task for automatic question answering. To…

Computation and Language · Computer Science 2024-03-22 Víctor Ponce-López

The classification of amino acids and their sequence analysis plays a vital role in life sciences and is a challenging task. This article uses and compares state-of-the-art deep learning models like convolution neural networks (CNN), long…

Biomolecules · Quantitative Biology 2022-07-26 Sarwar Khan , Faisal Ghaffar , Imad Ali , Qazi Mazhar

The development of LLMs has greatly enhanced the intelligence and fluency of question answering, while the emergence of retrieval enhancement has enabled models to better utilize external information. However, the presence of noise and…

Computation and Language · Computer Science 2024-09-19 Xingyun Hong , Yan Shao , Zhilin Wang , Manni Duan , Jin Xiongnan

Large Language Models (LLMs) have demonstrated significant potential in transforming clinical applications. In this study, we investigate the efficacy of four techniques in adapting LLMs for clinical use-cases: continuous pretraining,…

Large Language Models have demonstrated remarkable abilities in reasoning and planning by breaking down complex problems into sequential steps. Despite their success in various domains like mathematical problem-solving and coding, LLMs face…

Artificial Intelligence · Computer Science 2024-10-29 Chang Ma , Haiteng Zhao , Junlei Zhang , Junxian He , Lingpeng Kong

Despite the inherent limitations of existing Large Language Models in directly reading and interpreting single-cell omics data, they demonstrate significant potential and flexibility as the Foundation Model. This research focuses on how to…

Genomics · Quantitative Biology 2024-02-21 Cong Li , Meng Xiao , Pengfei Wang , Guihai Feng , Xin Li , Yuanchun Zhou

Training AI models in cybersecurity with help of vast datasets offers significant opportunities to mimic real-world behaviors effectively. However, challenges like data drift and scarcity of labelled data lead to frequent updates of models…

Machine Learning · Computer Science 2026-02-04 Saurabh Anand , Shubham Malaviya , Manish Shukla , Sachin Lodha