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To enhance the performance of large language models (LLMs) in biomedical natural language processing (BioNLP) by introducing a domain-specific instruction dataset and examining its impact when combined with multi-task learning principles.…

Computation and Language · Computer Science 2024-06-10 Hieu Tran , Zhichao Yang , Zonghai Yao , Hong Yu

Large language models (LLMs) such as ChatGPT are fine-tuned on large and diverse instruction-following corpora, and can generalize to new tasks. However, those instruction-tuned LLMs often perform poorly in specialized medical natural…

Computation and Language · Computer Science 2025-03-11 Yujuan Velvin Fu , Giridhar Kaushik Ramachandran , Namu Park , Kevin Lybarger , Fei Xia , Ozlem Uzuner , Meliha Yetisgen

Natural language processing (NLP) is a key technology to extract important patient information from clinical narratives to support healthcare applications. The rapid development of large language models (LLMs) has revolutionized many NLP…

Computation and Language · Computer Science 2025-09-08 Cheng Peng , Xinyu Dong , Mengxian Lyu , Daniel Paredes , Yaoyun Zhang , Yonghui Wu

Large Language Models (LLMs) have shown promising results on machine translation for high resource language pairs and domains. However, in specialised domains (e.g. medical) LLMs have shown lower performance compared to standard neural…

Computation and Language · Computer Science 2025-07-31 Miguel Rios

Large Language Models (LLMs) are expected to significantly contribute to patient care, diagnostics, and administrative processes. Emerging biomedical LLMs aim to address healthcare-specific challenges, including privacy demands and…

Computation and Language · Computer Science 2025-10-14 Amin Dada , Marie Bauer , Amanda Butler Contreras , Osman Alperen Koraş , Constantin Marc Seibold , Kaleb E Smith , Jens Kleesiek

Cutting edge techniques developed in the general NLP domain are often subsequently applied to the high-value, data-rich biomedical domain. The past few years have seen generative language models (LMs), instruction finetuning, and few-shot…

Computation and Language · Computer Science 2025-07-28 Aviv Brokman , Ramakanth Kavuluru

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…

Motivation: A perennial challenge for biomedical researchers and clinical practitioners is to stay abreast with the rapid growth of publications and medical notes. Natural language processing (NLP) has emerged as a promising direction for…

Computation and Language · Computer Science 2021-12-16 Robert Tinn , Hao Cheng , Yu Gu , Naoto Usuyama , Xiaodong Liu , Tristan Naumann , Jianfeng Gao , Hoifung Poon

The success of ChatGPT has recently attracted numerous efforts to replicate it, with instruction-tuning strategies being a key factor in achieving remarkable results. Instruction-tuning not only significantly enhances the model's…

Computation and Language · Computer Science 2023-03-28 Yunjie Ji , Yong Deng , Yan Gong , Yiping Peng , Qiang Niu , Lei Zhang , Baochang Ma , Xiangang Li

We evaluate four state-of-the-art instruction-tuned large language models (LLMs) -- ChatGPT, Flan-T5 UL2, Tk-Instruct, and Alpaca -- on a set of 13 real-world clinical and biomedical natural language processing (NLP) tasks in English, such…

Computation and Language · Computer Science 2024-06-11 Yanis Labrak , Mickael Rouvier , Richard Dufour

Large language models have exhibited exceptional performance on various Natural Language Processing (NLP) tasks, leveraging techniques such as the pre-training, and instruction fine-tuning. Despite these advances, their effectiveness in…

Computation and Language · Computer Science 2023-06-19 Guangyu Wang , Guoxing Yang , Zongxin Du , Longjun Fan , Xiaohu Li

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

Computation and Language · Computer Science 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang

Instruction tuning is crucial for enabling Large Language Models (LLMs) to solve real-world tasks. Prior work has shown the effectiveness of instruction-tuning data synthesized solely from LLMs, raising a fundamental question: Do we still…

Proprietary Large Language Models (LLMs), such as ChatGPT, have garnered significant attention due to their exceptional capabilities in handling a diverse range of tasks. Recent studies demonstrate that open-sourced smaller foundational…

Computation and Language · Computer Science 2023-10-10 Yue Zhang , Leyang Cui , Deng Cai , Xinting Huang , Tao Fang , Wei Bi

Instruction-tuned Large Language Models (LLMs) can perform a wide range of tasks given natural language instructions to do so, but they are sensitive to how such instructions are phrased. This issue is especially concerning in healthcare,…

Fine-tuning pre-trained large language models (LLMs) on a diverse array of tasks has become a common approach for building models that can solve various natural language processing (NLP) tasks. However, where and to what extent these models…

Computation and Language · Computer Science 2024-10-29 Zheng Zhao , Yftah Ziser , Shay B. Cohen

Large Language Models (LLMs) have achieved remarkable success, where instruction tuning is the critical step in aligning LLMs with user intentions. In this work, we investigate how the instruction tuning adjusts pre-trained models with a…

Computation and Language · Computer Science 2024-04-05 Xuansheng Wu , Wenlin Yao , Jianshu Chen , Xiaoman Pan , Xiaoyang Wang , Ninghao Liu , Dong Yu

Large language models (LLMs), such as ChatGPT, have received substantial attention due to their capabilities for understanding and generating human language. While there has been a burgeoning trend in research focusing on the employment of…

In the swiftly expanding domain of Natural Language Processing (NLP), the potential of GPT-based models for the financial sector is increasingly evident. However, the integration of these models with financial datasets presents challenges,…

Computation and Language · Computer Science 2023-11-14 Neng Wang , Hongyang Yang , Christina Dan Wang

Advancements in Large Language Models (LLMs) have significantly enhanced instruction-following capabilities. However, most Instruction Fine-Tuning (IFT) datasets are predominantly in English, limiting model performance in other languages.…

Computation and Language · Computer Science 2024-07-03 Sathish Reddy Indurthi , Wenxuan Zhou , Shamil Chollampatt , Ravi Agrawal , Kaiqiang Song , Lingxiao Zhao , Chenguang Zhu
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