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BrainScaleS-2 is a mixed-signal accelerated neuromorphic system targeted for research in the fields of computational neuroscience and beyond-von-Neumann computing. To augment its flexibility, the analog neural network core is accompanied by…

Neural and Evolutionary Computing · Computer Science 2020-04-01 Eric Müller , Christian Mauch , Philipp Spilger , Oliver Julien Breitwieser , Johann Klähn , David Stöckel , Timo Wunderlich , Johannes Schemmel

The complete connectome of the Drosophila larva brain offers a unique opportunity to investigate whether biologically evolved circuits can support artificial intelligence. We convert this wiring diagram into a Biological Processing Unit…

Neural and Evolutionary Computing · Computer Science 2025-07-16 Siyu Yu , Zihan Qin , Tingshan Liu , Beiya Xu , R. Jacob Vogelstein , Jason Brown , Joshua T. Vogelstein

The BrainScaleS-2 (BSS-2) system implements physical models of neurons as well as synapses and aims for an energy-efficient and fast emulation of biological neurons. When replicating neuroscientific experiments on BSS-2, a major challenge…

Neural and Evolutionary Computing · Computer Science 2023-11-21 Jakob Kaiser , Raphael Stock , Eric Müller , Johannes Schemmel , Sebastian Schmitt

Insects have long been recognized for their ability to navigate and return home using visual cues from their nest's environment. However, the precise mechanism underlying this remarkable homing skill remains a subject of ongoing…

Robotics · Computer Science 2024-05-08 Michiel Firlefyn , Jesse Hagenaars , Guido de Croon

The BrainScaleS-2 (BSS-2) Neuromorphic Computing System currently consists of multiple single-chip setups, which are connected to a compute cluster via Gigabit-Ethernet network technology. This is convenient for small experiments, where the…

Hardware Architecture · Computer Science 2022-03-04 Tobias Thommes , Sven Bordukat , Andreas Grübl , Vitali Karasenko , Eric Müller , Johannes Schemmel

The study of plasticity in spiking neural networks is an active area of research. However, simulations that involve complex plasticity rules, dense connectivity/high synapse counts, complex neuron morphologies, or extended simulation times…

Neural and Evolutionary Computing · Computer Science 2024-12-05 Philipp Spilger , Eric Müller , Johannes Schemmel

Neuromorphic systems open up opportunities to enlarge the explorative space for computational research. However, it is often challenging to unite efficiency and usability. This work presents the software aspects of this endeavor for the…

We introduce bio-inspired artificial neural networks consisting of neurons that are additionally characterized by spatial positions. To simulate properties of biological systems we add the costs penalizing long connections and the proximity…

Neural and Evolutionary Computing · Computer Science 2019-10-08 Maciej Wołczyk , Jacek Tabor , Marek Śmieja , Szymon Maszke

The massively parallel nature of biological information processing plays an important role for its superiority to human-engineered computing devices. In particular, it may hold the key to overcoming the von Neumann bottleneck that limits…

The first-generation of BrainScaleS, also referred to as BrainScaleS-1, is a neuromorphic system for emulating large-scale networks of spiking neurons. Following a "physical modeling" principle, its VLSI circuits are designed to emulate the…

While bio-inspired and biomimetic systems draw inspiration from living materials, biohybrid systems incorporate them with synthetic devices, allowing the exploitation of both organic and artificial advantages inside a single entity. In the…

Robotics · Computer Science 2022-11-22 Huu Duoc Nguyen , Van Than Dung , Hirotaka Sato , T. Thang Vo-Doan

Despite remarkable capabilities, artificial neural networks exhibit limited flexible, generalizable intelligence. This limitation stems from their fundamental divergence from biological cognition that overlooks both neural regions'…

Artificial Intelligence · Computer Science 2025-11-05 Boheng Liu , Ziyu Li , Qing Li , Xia Wu

The evolution of biological brains has always been contingent on their embodiment within their respective environments, in which survival required appropriate navigation and manipulation skills. Studying such interactions thus represents an…

Neurons and Cognition · Quantitative Biology 2020-05-01 K. Schreiber , T. C. Wunderlich , C. Pehle , M. A. Petrovici , J. Schemmel , K. Meier

Efficient path planning and navigation is critical for animals, robotics, logistics and transportation. We study a model in which spatial navigation problems can rapidly be solved in the brain by parallel mental exploration of alternative…

Neurons and Cognition · Quantitative Biology 2012-05-03 Filip Ponulak , John J. Hopfield

Artificial neural networks and computational neuroscience models have made tremendous progress, allowing computers to achieve impressive results in artificial intelligence (AI) applications, such as image recognition, natural language…

Neural and Evolutionary Computing · Computer Science 2019-11-05 Giacomo Indiveri , Yulia Sandamirskaya

We demonstrate the first-ever nontrivial, biologically realistic connectome simulated on neuromorphic computing hardware. Specifically, we implement the whole-brain connectome of the adult Drosophila melanogaster (fruit fly) from the…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-08-26 Felix Wang , Bradley H. Theilman , Fred Rothganger , William Severa , Craig M. Vineyard , James B. Aimone

Many animals meander in environments and avoid collisions. How the underlying neuronal machinery can yield robust behaviour in a variety of environments remains unclear. In the fly brain, motion-sensitive neurons indicate the presence of…

Neural and Evolutionary Computing · Computer Science 2021-02-18 Thorben Schoepe , Ella Janotte , Moritz B. Milde , Olivier J. N. Bertrand , Martin Egelhaaf , Elisabetta Chicca

The complex and unique neural network topology of the human brain formed through natural evolution enables it to perform multiple cognitive functions simultaneously. Automated evolutionary mechanisms of biological network structure inspire…

Neural and Evolutionary Computing · Computer Science 2023-09-12 Wenxuan Pan , Feifei Zhao , Zhuoya Zhao , Yi Zeng

Emulating spiking neural networks on analog neuromorphic hardware offers several advantages over simulating them on conventional computers, particularly in terms of speed and energy consumption. However, this usually comes at the cost of…

The nervous system, more specifically, the brain, is capable of solving complex problems simply and efficiently, far surpassing modern computers. In this regard, neuromorphic engineering is a research field that focuses on mimicking the…

Neural and Evolutionary Computing · Computer Science 2022-06-13 Daniel Casanueva-Morato , Alvaro Ayuso-Martinez , Juan P. Dominguez-Morales , Angel Jimenez-Fernandez , Gabriel Jimenez-Moreno