Related papers: Cell information processing via frequency encoding…
Ca$^{2+}$ plays an important role in cell signal transduction. Its intracellular propagation is the most basic process of Ca$^{2+}$ signaling, such as calcium wave and double messenger system. In this work, with both numerical simulation…
In terms of the long-distance communication of a single neuron, interpulse intervals (IPIs) are a possible alternative to rate and binary codes. As a proxy for IPI, the time-to-spike (TTS) for a neuron can be found in the biophysical and…
We use Ru $L_3$-edge resonant inelastic x-ray scattering (RIXS) to study the full range of excitations in Ca$_3$Ru$_2$O$_7$ from meV-scale magnetic dynamics through to the eV-scale interband transitions. This bilayer $4d$-electron…
Neural oscillations are universal phenomena and can be observed at different levels of neural systems, from single neuron to macroscopic brain. The frequency of those oscillations are related to the brain functions. However, little is know…
Fluctuations in intracellular reactions (intrinsic noise) reduce the information transmitted from an extracellular input to a cellular response. However, recent studies have demonstrated that the decrease in the transmitted information with…
Epilepsy is a neurological disorder with recurrent seizures of complexity and randomness. Until now, the mechanism of epileptic randomness has not been fully elucidated. Inspired by the recent finding that astrocyte GTPase-activating…
Intermittent transitions, associated with critical dynamics and characterized by power-law distributions, are commonly observed during sleep. These critical behaviors are evident at the microscopic level through neuronal avalanches and at…
Presented with sensory challenges, living cells employ extensive noisy, fluctuating signalling and communication among themselves to compute a physiologically proper response which often results in symmetry breaking. We propose, based on…
Many cell types exhibit oscillatory activity, such as repetitive action potential firing due to the Hodgkin-Huxley dynamics of ion channels in the cell membrane or reveal intracellular inositol triphosphate (IP$_3$) mediated calcium…
We analyze oscillatory instabilities for a coupled PDE-ODE system modeling the communication between localized spatially segregated dynamically active signaling compartments that are coupled through a passive extracellular bulk diffusion…
The objective was to determine the effect of pulse rate on the sensitivity to use interaural-time-difference (ITD) cues and to explore the mechanisms behind rate-dependent degradation in ITD perception in bilateral cochlear implant (CI)…
In this paper, we study analytically the impact of an inhibitory autapse on neuronal activity. In order to do this, we formulate conditions on a set of non-adaptive spiking neuron models with delayed feedback inhibition, instead of…
We consider a threshold-crossing spiking process as a simple model for the activity within a population of neurons. Assuming that these neurons are driven by a common fluctuating input with Gaussian statistics, we evaluate the…
Inferring the directionality of interactions between cellular processes is a major challenge in systems biology. Time-lagged correlations allow to discriminate between alternative models, but they still rely on assumed underlying…
Cells sense external concentrations and, via biochemical signaling, respond by regulating the expression of target proteins. Both in signaling networks and gene regulation there are two main mechanisms by which the concentration can be…
How the information microscopically processed by individual neurons is integrated and used in organizing the behavior of an animal is a central question in neuroscience. The coherence of neuronal dynamics over different scales has been…
We have investigated the spin fluctuations at energy transfers up to ~110 meV, well above the resonance energy (33 meV) in the YBa2Cu3O6.5 ortho-II superconductor using neutron time-of-flight and triple-axis techniques. The spectrum at high…
We study the activation process in large assemblies of type II excitable units whose dynamics is influenced by two independent noise terms. The mean-field approach is applied to explicitly demonstrate that the assembly of excitable units…
Unicellular organisms are open metabolic systems that need to process information about their external environment in order to survive. In most types of tissues and organisms, cells use calcium signaling to carry information from the…
We study the response of a Hodgkin-Huxley neuron stimulated by a periodic sequence of conductance pulses arriving through the synapse in the high frequency regime. In addition to the usual excitation threshold there is a smooth crossover…