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Training-free guidance methods for continuous data have seen an explosion of interest due to the fact that they enable foundation diffusion models to be paired with interchangable guidance models. Currently, equivalent guidance methods for…

Machine Learning · Statistics 2024-09-12 Thomas J. Kerby , Kevin R. Moon

This work introduces DiGress, a discrete denoising diffusion model for generating graphs with categorical node and edge attributes. Our model utilizes a discrete diffusion process that progressively edits graphs with noise, through the…

Machine Learning · Computer Science 2023-05-24 Clement Vignac , Igor Krawczuk , Antoine Siraudin , Bohan Wang , Volkan Cevher , Pascal Frossard

Learning the underlying distribution of molecular graphs and generating high-fidelity samples is a fundamental research problem in drug discovery and material science. However, accurately modeling distribution and rapidly generating novel…

Machine Learning · Computer Science 2023-05-24 Han Huang , Leilei Sun , Bowen Du , Weifeng Lv

Classifier-free guidance (CFG) is a widely used technique for improving the perceptual quality of samples from conditional diffusion models. It operates by linearly combining conditional and unconditional score estimates using a guidance…

Machine Learning · Computer Science 2025-10-02 Alexandre Galashov , Ashwini Pokle , Arnaud Doucet , Arthur Gretton , Mauricio Delbracio , Valentin De Bortoli

Controllable molecular graph generation is essential for material and drug discovery, where generated molecules must satisfy diverse property constraints. While recent advances in graph diffusion models have improved generation quality,…

Machine Learning · Computer Science 2025-09-30 Anjie Qiao , Zhen Wang , Chuan Chen , DeFu Lian , Enhong Chen

Given an unconditional diffusion model and a predictor for a target property of interest (e.g., a classifier), the goal of training-free guidance is to generate samples with desirable target properties without additional training. Existing…

Machine Learning · Computer Science 2024-11-20 Haotian Ye , Haowei Lin , Jiaqi Han , Minkai Xu , Sheng Liu , Yitao Liang , Jianzhu Ma , James Zou , Stefano Ermon

This paper presents Model-guidance (MG), a novel objective for training diffusion model that addresses and removes of the commonly used Classifier-free guidance (CFG). Our innovative approach transcends the standard modeling of solely data…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Zhicong Tang , Jianmin Bao , Dong Chen , Baining Guo

Recent advances in diffusion models have shown remarkable potential in the conditional generation of novel molecules. These models can be guided in two ways: (i) explicitly, through additional features representing the condition, or (ii)…

Machine Learning · Computer Science 2025-03-12 Yuchen Shen , Chenhao Zhang , Sijie Fu , Chenghui Zhou , Newell Washburn , Barnabás Póczos

Classifier guidance is a recently introduced method to trade off mode coverage and sample fidelity in conditional diffusion models post training, in the same spirit as low temperature sampling or truncation in other types of generative…

Machine Learning · Computer Science 2022-07-27 Jonathan Ho , Tim Salimans

Classifier-Free Guidance (CFG) is a widely adopted technique in diffusion and flow-based generative models, enabling high-quality conditional generation. A key theoretical challenge is characterizing the distribution induced by CFG,…

Machine Learning · Computer Science 2025-05-23 Krunoslav Lehman Pavasovic , Jakob Verbeek , Giulio Biroli , Marc Mezard

Diffusion models achieve state-of-the-art performance in generating realistic objects and have been successfully applied to images, text, and videos. Recent work has shown that diffusion can also be defined on graphs, including graph…

Machine Learning · Computer Science 2023-02-09 Alex M. Tseng , Nathaniel Diamant , Tommaso Biancalani , Gabriele Scalia

The ability to rapidly develop materials with desired properties has a transformative impact on a broad range of emerging technologies. In this work, we introduce a new framework based on the diffusion model, a recent generative machine…

Scene graphs (SGs) represent objects and their relationships as structured graphs, enabling applications in image generation, robotics, and 3D understanding. Recent work suggests that conditioning image generation on scene graphs improves…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Rajalaxmi Rajagopalan , Romit Roy Choudhury

Graph property prediction tasks are important and numerous. While each task offers a small size of labeled examples, unlabeled graphs have been collected from various sources and at a large scale. A conventional approach is training a model…

Machine Learning · Computer Science 2023-10-13 Gang Liu , Eric Inae , Tong Zhao , Jiaxin Xu , Tengfei Luo , Meng Jiang

Classifier-free guidance (CFG) has become the standard method for enhancing the quality of conditional diffusion models. However, employing CFG requires either training an unconditional model alongside the main diffusion model or modifying…

Machine Learning · Computer Science 2025-06-04 Seyedmorteza Sadat , Manuel Kansy , Otmar Hilliges , Romann M. Weber

Classifier-Free Guidance (CFG) is a widely used technique for improving conditional diffusion models by linearly combining the outputs of conditional and unconditional denoisers. While CFG enhances visual quality and improves alignment with…

Machine Learning · Computer Science 2025-05-28 Badr Moufad , Yazid Janati , Alain Durmus , Ahmed Ghorbel , Eric Moulines , Jimmy Olsson

Classifier-Free Guidance (CFG) is a cornerstone of modern conditional diffusion models, yet its reliance on the fixed or heuristic dynamic guidance weight is predominantly empirical and overlooks the inherent dynamics of the diffusion…

Machine Learning · Computer Science 2026-05-21 Jiayang Gao , Tianyi Zheng , Jiayang Zou , Fengxiang Yang , Shice Liu , Luyao Fan , Zheyu Zhang , Hao Zhang , Jinwei Chen , Peng-Tao Jiang , Bo Li , Jia Wang

Optimizing chemical properties is a challenging task due to the vastness and complexity of chemical space. Here, we present a generative energy-based architecture for implicit chemical property optimization, designed to efficiently generate…

Biomolecules · Quantitative Biology 2025-06-19 Luca Miglior , Lorenzo Simone , Marco Podda , Davide Bacciu

Image generation using diffusion models have demonstrated outstanding learning capabilities, effectively capturing the full distribution of the training dataset. They are known to generate wide variations in sampled images, albeit with a…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Rahul Shenoy , Zhihong Pan , Kaushik Balakrishnan , Qisen Cheng , Yongmoon Jeon , Heejune Yang , Jaewon Kim

Image classification is a well-studied task in computer vision, and yet it remains challenging under high-uncertainty conditions, such as when input images are corrupted or training data are limited. Conventional classification approaches…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Omer Belhasin , Shelly Golan , Ran El-Yaniv , Michael Elad
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