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Cell identification within the H&E slides is an essential prerequisite that can pave the way towards further pathology analyses including tissue classification, cancer grading, and phenotype prediction. However, performing such a task using…

Computer Vision and Pattern Recognition · Computer Science 2023-01-18 Ramin Nakhli , Amirali Darbandsari , Hossein Farahani , Ali Bashashati

While contrastive learning is proven to be an effective training strategy in computer vision, Natural Language Processing (NLP) is only recently adopting it as a self-supervised alternative to Masked Language Modeling (MLM) for improving…

Computation and Language · Computer Science 2021-09-16 Hooman Sedghamiz , Shivam Raval , Enrico Santus , Tuka Alhanai , Mohammad Ghassemi

In this paper, we propose a one-stage online clustering method called Contrastive Clustering (CC) which explicitly performs the instance- and cluster-level contrastive learning. To be specific, for a given dataset, the positive and negative…

Machine Learning · Computer Science 2020-09-22 Yunfan Li , Peng Hu , Zitao Liu , Dezhong Peng , Joey Tianyi Zhou , Xi Peng

Biologically inspired spiking neural networks (SNNs) have garnered considerable attention due to their low-energy consumption and spatio-temporal information processing capabilities. Most existing SNNs training methods first integrate…

Computer Vision and Pattern Recognition · Computer Science 2023-05-24 Haonan Qiu , Zeyin Song , Yanqi Chen , Munan Ning , Wei Fang , Tao Sun , Zhengyu Ma , Li Yuan , Yonghong Tian

Contrastive learning has gained significant attention in short text clustering, yet it has an inherent drawback of mistakenly identifying samples from the same category as negatives and then separating them in the feature space (false…

Machine Learning · Computer Science 2026-03-16 Zhihao Yao

Disease diagnosis from medical images via supervised learning is usually dependent on tedious, error-prone, and costly image labeling by medical experts. Alternatively, semi-supervised learning and self-supervised learning offer…

Computer Vision and Pattern Recognition · Computer Science 2023-06-14 Attiano Purpura-Pontoniere , Demetri Terzopoulos , Adam Wang , Abdullah-Al-Zubaer Imran

Learning semantic-rich representations from raw unlabeled time series data is critical for downstream tasks such as classification and forecasting. Contrastive learning has recently shown its promising representation learning capability in…

Machine Learning · Computer Science 2023-03-31 Qianwen Meng , Hangwei Qian , Yong Liu , Lizhen Cui , Yonghui Xu , Zhiqi Shen

Single-cell RNA sequencing (scRNA-seq) data analysis is pivotal for understanding cellular heterogeneity. However, the high sparsity and complex noise patterns inherent in scRNA-seq data present significant challenges for traditional…

Genomics · Quantitative Biology 2024-08-13 Wenwen Min , Zhen Wang , Fangfang Zhu , Taosheng Xu , Shunfang Wang

Accurate cell type annotation is a crucial step in analyzing single-cell RNA sequencing (scRNA-seq) data, which provides valuable insights into cellular heterogeneity. However, due to the high dimensionality and prevalence of zero elements…

Machine Learning · Computer Science 2025-08-14 Huifa Li , Jie Fu , Xinlin Zhuang , Haolin Yang , Xinpeng Ling , Tong Cheng , Haochen xue , Imran Razzak , Zhili Chen

This paper proposes to perform online clustering by conducting twin contrastive learning (TCL) at the instance and cluster level. Specifically, we find that when the data is projected into a feature space with a dimensionality of the target…

Machine Learning · Computer Science 2022-10-24 Yunfan Li , Mouxing Yang , Dezhong Peng , Taihao Li , Jiantao Huang , Xi Peng

The single-cell RNA sequencing (scRNA-seq) technology enables researchers to study complex biological systems and diseases with high resolution. The central challenge is synthesizing enough scRNA-seq samples; insufficient samples can impede…

Genomics · Quantitative Biology 2023-12-25 Yixuan Wang , Shuangyin Li , Shimin DI , Lei Chen

Part feature learning is critical for fine-grained semantic understanding in vehicle re-identification. However, existing approaches directly model part features and global features, which can easily lead to serious gradient vanishing…

Computer Vision and Pattern Recognition · Computer Science 2023-03-17 Fei Shen , Xiaoyu Du , Liyan Zhang , Xiangbo Shu , Jinhui Tang

Continual Learning (CL) investigates how to train Deep Networks on a stream of tasks without incurring forgetting. CL settings proposed in literature assume that every incoming example is paired with ground-truth annotations. However, this…

Machine Learning · Statistics 2022-08-30 Matteo Boschini , Pietro Buzzega , Lorenzo Bonicelli , Angelo Porrello , Simone Calderara

Since its selection as the method of the year in 2013, single-cell technologies have become mature enough to provide answers to complex research questions. With the growth of single-cell profiling technologies, there has also been a…

Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the cellular level. By providing data on gene expression for each individual cell, scRNA-seq generates large datasets with thousands of…

Computational Complexity · Computer Science 2025-02-11 Md Romizul Islam , Swakkhar Shatabda

Semi-supervised learning utilizes insights from unlabeled data to improve model generalization, thereby reducing reliance on large labeled datasets. Most existing studies focus on limited samples and fail to capture the overall data…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Xiuzhen Guo , Lianyuan Yu , Ji Shi , Na Lei , Hongxiao Wang

Single-cell RNA-Sequencing (scRNA-Seq) is a revolutionary technique for discovering and describing cell types in heterogeneous tissues, yet its measurement of expression often suffers from large systematic bias. A major source of this bias…

Quantitative Methods · Quantitative Biology 2016-05-17 Martin Barron , Jun Li

Clustering analysis is fundamental in single-cell RNA sequencing (scRNA-seq) data analysis for elucidating cellular heterogeneity and diversity. Recent graph-based scRNA-seq clustering methods, particularly graph neural networks (GNNs),…

Machine Learning · Computer Science 2025-07-15 Ping Xu , Pengfei Wang , Zhiyuan Ning , Meng Xiao , Min Wu , Yuanchun Zhou

Subspace clustering aims to group data points that lie in a union of low-dimensional subspaces and finds wide application in computer vision, hyperspectral imaging, and recommendation systems. However, most existing methods assume fully…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Huanran Li , Daniel Pimentel-Alarcón

Clustering is the task of gathering similar data samples into clusters without using any predefined labels. It has been widely studied in machine learning literature, and recent advancements in deep learning have revived interest in this…

Machine Learning · Computer Science 2023-09-04 Mohammadreza Sadeghi , Hadi Hojjati , Narges Armanfard