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Treatment planning in ion beam therapy requires accurate knowledge of the relative stopping power (RSP) distribution within the patient. Currently, RSP maps are obtained via conventional x-ray computed tomography (CT) by converting the…

For dose calculations in ion beam therapy, it is vital to accurately determine the relative stopping power (RSP) distribution within the treated volume. Currently, RSP values are extrapolated from Hounsfield units (HU), measured with x-ray…

Proton computed tomography (CT) is similar to x-ray CT but relies on protons rather than photons to form an image. In its most common operation mode, the measured quantity is the amount of energy that a proton has lost while traversing the…

Medical Physics · Physics 2022-08-17 Nils Krah , Denis Dauvergne , Jean Michel Létang , Simon Rit , Étienne Testa

The Time-of-Flight (ToF) technique coupled with semiconductor-like detectors, as silicon carbide and diamond, is one of the most promising diagnostic methods for high-energy, high repetition rate, laser-accelerated ions allowing a full…

The purpose of this study was to show how advanced concepts of compact, lossless and "Time Of Flight" (TOF) capable electronics similar to those foreseen for the LHC and ILC experiments could be fairly and easily transferred to the medical…

Instrumentation and Detectors · Physics 2009-08-03 P. -E. Vert , J. Lecoq , G. Montarou , N. Pauna , B. Joly , M. Boutemeur , H. Mathez , R. Gaglione , P. Le Dû

Time-Of-Flight (TOF) is a noble technique that is used in Positron Emission Tomography (PET) imaging worldwide. The scintillator based imaging system that is being used around the world for TOF-PET is very expensive. Multi-gap Resistive…

Instrumentation and Detectors · Physics 2018-07-02 Rajesh Ganai , Shaifali Mehta , Mehulkumar Shiroya , Mitali Mondal , Zubayer Ahammed , Subhasis Chattopadhyay

Recently, we reported an ion trap experiment with an integrated time-of-flight mass spectrometer (TOFMS) [Phys. Rev. Appl. 2, 034013 (2014)] focussing on the improvement of mass resolution and detection limit due to sample preparation at…

Atomic Physics · Physics 2016-01-20 Christian Schneider , Steven J. Schowalter , Peter Yu , Eric R. Hudson

Plastic scintillation detectors for Time-of-Flight (TOF) measurements are almost essential for event-by-event identification of relativistic rare isotopes. In this work, a pair of plastic scintillation detectors of 50 $\times$ 50 $\times$…

Verification of patient specific proton stopping powers obtained in the patient treatment position can be used to reduce the distal margins needed in particle beam planning. Proton radiography can be used as a pre-treatment instrument to…

With the emergence of advanced Silicon (Si) sensor technologies such as LGADs, it is now possible to achieve exceptional time measurement precision below 50 ps. As a result, the implementation of time-of-flight (TOF) particle identification…

High Energy Physics - Experiment · Physics 2023-11-09 Bohdan Dudar , Ulrich Einhaus , Jenny List , Konrad Helms , Frank Gaede

Intraoperative Gamma Probe (IPG) remains the current gold standard modality for sentinel lymph node identification and tumor removal in cancer patients. However, even alongside the optical dyes they do not meet with <5% false negative rates…

Medical Physics · Physics 2022-01-26 S. Sajedi , L. Blackberg , S. Majewski , H. Sabet

Cone beam computed tomography (CBCT) for breast imaging has potential to replace conventional mammograms. However, concerns over dose and image quality prevent CBBCT systems from the clinical trial phase to next stage. The time of flight…

Medical Physics · Physics 2021-02-01 Ignacio O. Romero , Changqing Li

Time-of-flight (ToF) measurements is a possible alternative to anti-scatter grids in computed tomography (CT). Simulations have shown a possible 75% reduction in the detrimental scattering contribution with a 100 ps FWHM timing resolution.…

3D time-of-flight (ToF) imaging is used in a variety of applications such as augmented reality (AR), computer interfaces, robotics and autonomous systems. Single-photon avalanche diodes (SPADs) are one of the enabling technologies providing…

Image and Video Processing · Electrical Eng. & Systems 2021-10-13 Germán Mora-Martín , Alex Turpin , Alice Ruget , Abderrahim Halimi , Robert Henderson , Jonathan Leach , Istvan Gyongy

Ion-pair dissociation (IPD) to gas phase carbon dioxide molecule has been studied using time of flight (TOF) based mass spectroscopy in combination with the highly differential velocity slice imaging (VSI) technique. The appearance energy…

Atomic Physics · Physics 2020-09-01 Narayan Kundu , Sumit Naskar , Irina Jana , Anirban Paul , Dhananjay Nandi

Time-Of-Flight (TOF) technique coupled with semiconductor detectors is a powerful instrument to provide real-time characterization of ions accelerated because of laser-matter interactions. Nevertheless, the presence of strong…

The accuracy of hadrontherapy treatment is currently limited by ion-range uncertainties. In order to fully exploit the potential of this technique, we propose the development of a novel system for online control of particle therapy, based…

Two major challenges in time-of-flight positron emission tomography (TOF-PET) are low spatial resolution and high radioactive dose to the patient, both of which result from limitations in detection technology rather than fundamental…

Fast procedures for the beam quality assessment and for the monitoring of beam energy modulations during the irradiation are among the most urgent improvements in particle therapy. Indeed, the online measurement of the particle beam energy…

Back-n is a white neutron experimental facility at China Spallation Neutron Source (CSNS). The time structure of the primary proton beam make it fully applicable to use TOF (time-of-flight) method for neutron energy measuring. We implement…

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