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The phylogenetic tree space introduced by Billera, Holmes, and Vogtmann (BHV tree space) is a CAT(0) continuous space that represents trees with edge weights with an intrinsic geodesic distance measure. The geodesic distance measure unique…

Quantitative Methods · Quantitative Biology 2021-10-29 Yingying Ren , Sihan Zha , Jingwen Bi , José A. Sanchez , Cara Monical , Michelle Delcourt , Rosemary K. Guzman , Ruth Davidson

Phylogenetic trees summarize evolutionary relationships. The Billera-Holmes-Vogtmann (BHV) space for comparing phylogenetic trees has many elegant mathematical properties, but it does not encompass trees with differing leaf sets. To…

Populations and Evolution · Quantitative Biology 2025-08-12 Maria Alejandra Valdez Cabrera , Amy D Willis

Trajectory inference is a critical problem in single-cell transcriptomics, which aims to reconstruct the dynamic process underlying a population of cells from sequencing data. Of particular interest is the reconstruction of differentiation…

Genomics · Quantitative Biology 2026-04-06 Elodie Maignant , Tim Conrad , Christoph von Tycowicz

Phylogenetic trees describe the relationships between species in the evolutionary process, and provide information about the rates of diversification. To understand the mechanisms behind macroevolution, we consider a class of multitype…

Populations and Evolution · Quantitative Biology 2024-10-07 Mingqi He , Sophie Hautphenne , Yao-ban Chan

Phylogenetics uses alignments of molecular sequence data to learn about evolutionary trees relating species. Along branches, sequence evolution is modelled using a continuous-time Markov process characterised by an instantaneous rate…

Phylogenetic reconstruction aims at finding plausible hypotheses of the evolutionary history of genes or species based on genomic sequence information. The distinction of orthologous genes (genes that having a common ancestry and diverged…

Populations and Evolution · Quantitative Biology 2016-02-29 Marc Hellmuth , Nicolas Wieseke

Phylogenetic trees represent the evolutionary relationships between extant lineages, where extinct or non-sampled lineages are omitted. Extending the work of Stadler and collaborators, this paper focuses on the branch lengths in…

Populations and Evolution · Quantitative Biology 2025-10-16 Tobias Dieselhorst , Johannes Berg

We consider the NP-hard Tree Containment problem that has important applications in phylogenetics. The problem asks if a given leaf-labeled network contains a subdivision of a given leaf-labeled tree. We develop a fast algorithm for the…

Computational Complexity · Computer Science 2017-02-22 Mathias Weller

Compatibility of unrooted phylogenetic trees is a well studied problem in phylogenetics. It asks to determine whether for a set of k input trees there exists a larger tree (called a supertree) that contains the topologies of all k input…

Discrete Mathematics · Computer Science 2014-03-03 Alexander Grigoriev , Steven Kelk , Nela Lekic

Phylogenetic comparative methods are well established tools for using inter-species variation to analyse phenotypic evolution and adaptation. They are generally hampered, however, by predominantly univariate approaches and failure to…

Populations and Evolution · Quantitative Biology 2024-12-13 Krzysztof Bartoszek

The inference of the evolutionary history of a collection of organisms is a problem of fundamental importance in evolutionary biology. The abundance of DNA sequence data arising from genome sequencing projects has led to significant…

Populations and Evolution · Quantitative Biology 2015-07-07 Julia Chifman , Laura Kubatko

Ecological studies have now gone beyond measures of species turnover towards measures of phylogenetic and functional dissimilarity with a main objective: disentangling the processes that drive species distributions from local to broad…

Populations and Evolution · Quantitative Biology 2018-06-26 Sandrine Pavoine

In a population with haploid reproduction any individual has a single parent in the previous generation. If all genealogical distances among pairs of individuals (generations from the closest common ancestor) are known it is possible to…

Populations and Evolution · Quantitative Biology 2015-05-13 Luce Prignano , Maurizio Serva

Merge trees are a type of graph-based topological summary that tracks the evolution of connected components in the sublevel sets of scalar functions. They enjoy widespread applications in data analysis and scientific visualization. In this…

Computational Geometry · Computer Science 2022-02-03 Ellen Gasparovic , Elizabeth Munch , Steve Oudot , Katharine Turner , Bei Wang , Yusu Wang

A common problem in phylogenetics is to try to infer a species phylogeny from gene trees. We consider different variants of this problem. The first variant, called Unrestricted Minimal Episodes Inference, aims at inferring a species tree…

Populations and Evolution · Quantitative Biology 2019-08-12 Leo van Iersel , Remie Janssen , Mark Jones , Yukihiro Murakami , Norbert Zeh

In biology, a phylogenetic tree is a tool to represent the evolutionary relationship between species. Unfortunately, the classical Schr\"oder tree model is not adapted to take into account the chronology between the branching nodes. In…

Data Structures and Algorithms · Computer Science 2019-01-15 Olivier Bodini , Antoine Genitrini , Mehdi Naima

Earth's forests play an important role in the fight against climate change, and are in turn negatively affected by it. Effective monitoring of different tree species is essential to understanding and improving the health and biodiversity of…

Computer Vision and Pattern Recognition · Computer Science 2025-07-30 Venkatesh Ramesh , Arthur Ouaknine , David Rolnick

Ultametrics are an important class of distances used in applications such as phylogenetics, clustering and classification theory. Ultrametrics are essentially distances that can be represented by an edge-weighted rooted tree so that all of…

Combinatorics · Mathematics 2026-02-13 Katharina T. Huber , Vincent Moulton , Guillaume E. Scholz

Optimal transport provides a metric which quantifies the dissimilarity between probability measures. For measures supported in discrete metric spaces, finding the optimal transport distance has cubic time complexity in the size of the…

Machine Learning · Computer Science 2024-01-30 Samantha Chen , Puoya Tabaghi , Yusu Wang

Evolutionary relationships between species are represented by phylogenetic trees, but these relationships are subject to uncertainty due to the random nature of evolution. A geometry for the space of phylogenetic trees is necessary in order…

Statistics Theory · Mathematics 2022-09-21 Jonas Lueg , Maryam K. Garba , Tom M. W. Nye , Stephan F. Huckemann