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Computer-assisted synthesis planning aims to help chemists find better reaction pathways faster. Finding viable and short pathways from sugar molecules to value-added chemicals can be modeled as a retrosynthesis planning problem with a…

Other Computer Science · Computer Science 2019-11-19 Peihong Jiang , Hieu Doan , Sandeep Madireddy , Rajeev Surendran Assary , Prasanna Balaprakash

The integration of machine learning (ML) models enhances the efficiency, affordability, and reliability of feature detection in microscopy, yet their development and applicability are hindered by the dependency on scarce and often flawed…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Matthew J. Lynch , Ryan Jacobs , Gabriella Bruno , Priyam Patki , Dane Morgan , Kevin G. Field

High-level synthesis (HLS) is a widely used tool in designing Field Programmable Gate Array (FPGA). HLS enables FPGA design with software programming languages by compiling the source code into an FPGA circuit. The source code includes a…

Machine Learning · Computer Science 2025-03-17 Weikai Li , Ding Wang , Zijian Ding , Atefeh Sohrabizadeh , Zongyue Qin , Jason Cong , Yizhou Sun

Formal methods apply algorithms based on mathematical principles to enhance the reliability of systems. It would only be natural to try to progress from verification, model checking or testing a system against its formal specification into…

Software Engineering · Computer Science 2014-02-28 Gal Katz , Doron Peled

In recent years, the use of Machine Learning (ML) in computational chemistry has enabled numerous advances previously out of reach due to the computational complexity of traditional electronic-structure methods. One of the most promising…

Predictive benchmarking, the evaluation of machine learning models based on predictive performance and competitive ranking, is a central epistemic practice in machine learning research and an increasingly prominent method for scientific…

Machine Learning · Computer Science 2025-10-28 Timo Freiesleben , Sebastian Zezulka

Human decision-makers often receive assistance from data-driven algorithmic systems that provide a score for evaluating objects, including individuals. The scores are generated by a function (mechanism) that takes a set of features as input…

Machine Learning · Computer Science 2019-11-25 Abolfazl Asudeh , H. V. Jagadish

The dependency on the correct functioning of embedded systems is rapidly growing, mainly due to their wide range of applications, such as micro-grids, automotive device control, health care, surveillance, mobile devices, and consumer…

Logic in Computer Science · Computer Science 2017-03-01 Lucas Cordeiro

Reasoning on large and complex real-world models is a computationally difficult task, yet one that is required for effective use of many AI applications. A plethora of inference algorithms have been developed that work well on specific…

Artificial Intelligence · Computer Science 2016-06-13 Avi Pfeffer , Brian Ruttenberg , William Kretschmer

Evaluating sign language generation is often done through back-translation, where generated signs are first recognized back to text and then compared to a reference using text-based metrics. However, this two-step evaluation pipeline…

Computation and Language · Computer Science 2025-09-05 Saki Imai , Mert İnan , Anthony Sicilia , Malihe Alikhani

Causal modeling has long been an attractive topic for many researchers and in recent decades there has seen a surge in theoretical development and discovery algorithms. Generally discovery algorithms can be divided into two approaches:…

Machine Learning · Statistics 2017-02-06 Ridho Rahmadi , Perry Groot , Marianne Heins , Hans Knoop , Tom Heskes

Automated decision systems increasingly rely on human oversight to ensure accuracy in uncertain cases. This paper presents a practical framework for optimizing such human-in-the-loop classification systems using a double-threshold policy.…

Human-Computer Interaction · Computer Science 2026-01-13 Goran Muric , Steven Minton

Machine learning classification problems are widespread in bioinformatics, but the technical knowledge required to perform model training, optimization, and inference can prevent researchers from utilizing this technology. This article…

Machine Learning · Computer Science 2023-10-06 Aaron D. Mullen , Samuel E. Armstrong , Jeff Talbert , V. K. Cody Bumgardner

Program synthesis aims to automatically construct human-readable programs that satisfy given task specifications, such as input/output pairs or demonstrations. Recent works have demonstrated encouraging results in a variety of domains, such…

Software Engineering · Computer Science 2023-03-13 Linghan Zhong , Ryan Lindeborg , Jesse Zhang , Joseph J. Lim , Shao-Hua Sun

Even though thermodynamic energy-based crystal structure prediction (CSP) has revolutionized materials discovery, the energy-driven CSP approaches often struggle to identify experimentally realizable metastable materials synthesized through…

Materials Science · Physics 2025-05-15 Yu Xin , Peng Liu , Zhuohang Xie , Wenhui Mi , Pengyue Gao , Hong Jian Zhao , Jian Lv , Yanchao Wang , Yanming Ma

Program synthesis is the task of constructing a program conforming to a given specification. We focus on deductive synthesis, and in particular on synthesis problems with specifications given as $\forall\exists$-formulas, expressing the…

Logic in Computer Science · Computer Science 2025-08-15 Márton Hajdu , Petra Hozzová , Laura Kovács , Andrei Voronkov , Eva Maria Wagner , Richard Steven Žilinčík

Retrosynthesis is the task of breaking down a chemical compound recursively step-by-step into molecular precursors until a set of commercially available molecules is found. Consequently, the goal is to provide a valid synthesis route for a…

Rule-based systems remain central in safety-critical domains but often struggle with scalability, brittleness, and goal misspecification. These limitations can lead to reward hacking and failures in formal verification, as AI systems tend…

Logic in Computer Science · Computer Science 2026-05-12 Zainab Rehan , Christian Medeiros Adriano , Sona Ghahremani , Holger Giese

Large language models (LLMs) are widely adopted to generate synthetic datasets for various natural language processing (NLP) tasks, such as text classification and summarization. However, accurately measuring the diversity of these…

Computation and Language · Computer Science 2025-08-15 Yuchang Zhu , Huizhe Zhang , Bingzhe Wu , Jintang Li , Zibin Zheng , Peilin Zhao , Liang Chen , Yatao Bian

Fundamental differences between materials originate from the unique nature of their constituent chemical elements. Before specific differences emerge according to the precise ratios of elements in a given crystal structure, a material can…