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DNA data storage systems encode digital data into DNA strands, enabling dense and durable storage. Efficient data retrieval depends on coverage depth, a key performance metric. We study the random access coverage depth problem and focus on…

Information Theory · Computer Science 2025-07-29 Şeyma Bodur , Stefano Lia , Hiram H. López , Rati Ludhani , Alberto Ravagnani , Lisa Seccia

We consider the problem of constructing an erasure code for storage over a network when the data sources are distributed. Specifically, we assume that there are n storage nodes with limited memory and k<n sources generating the data. We…

Information Theory · Computer Science 2016-11-15 Alexandros G. Dimakis , Vinod Prabhakaran , Kannan Ramchandran

DNA, with remarkable properties of high density, durability, and replicability, is one of the most appealing storage media. Emerging DNA storage technologies use composite DNA letters, where information is represented by probability…

Information Theory · Computer Science 2025-03-26 Wenkai Zhang , Zhiying Wang

In this paper, we consider a concatenated coding based class of DNA storage codes in which the selected molecules are constrained to be taken from an ``inner'' codebook associated with the sequencing channel. This codebook is used in a…

Information Theory · Computer Science 2025-06-19 Yan Hao Ling , Jonathan Scarlett

DNA-based storage is an emerging technology that enables digital information to be archived in DNA molecules. This method enjoys major advantages over magnetic and optical storage solutions such as exceptional information density, enhanced…

Information Theory · Computer Science 2024-03-13 Daniella Bar-Lev , Itai Orr , Omer Sabary , Tuvi Etzion , Eitan Yaakobi

This paper tackles two problems that fall under the study of coding for insertions and deletions. These problems are motivated by several applications, among them is reconstructing strands in DNA-based storage systems. Under this paradigm,…

Information Theory · Computer Science 2025-06-23 Omer Sabary , Daniella Bar-Lev , Yotam Gershon , Alexander Yucovich , Eitan Yaakobi

We consider the problem of joint source and channel coding of structured data such as natural language over a noisy channel. The typical approach to this problem in both theory and practice involves performing source coding to first…

Information Theory · Computer Science 2018-02-21 Nariman Farsad , Milind Rao , Andrea Goldsmith

DNA is emerging as an increasingly attractive medium for data storage due to a number of important and unique advantages it offers, most notably the unprecedented durability and density. While the technology is evolving rapidly, the…

Emerging Technologies · Computer Science 2022-05-03 Dehui Lin , Yasamin Tabatabaee , Yash Pote , Djordje Jevdjic

Decoding sequences that stem from multiple transmissions of a codeword over an insertion, deletion, and substitution channel is a critical component of efficient deoxyribonucleic acid (DNA) data storage systems. In this paper, we consider a…

Information Theory · Computer Science 2020-10-30 Andreas Lenz , Issam Maarouf , Lorenz Welter , Antonia Wachter-Zeh , Eirik Rosnes , Alexandre Graell i Amat

We put forth new models for universal channel coding. Unlike standard codes which are designed for a specific type of channel, our most general universal code makes communication resilient on every channel, provided the noise level is below…

Information Theory · Computer Science 2022-12-12 Bruno Bauwens , Marius Zimand

We consider data transmission over a network where each edge is an erasure channel and where the inner nodes transmit a random linear combination of their incoming information. We distinguish two channel models in this setting, the row and…

Information Theory · Computer Science 2017-10-18 Heide Gluesing-Luerssen , Anna-Lena Horlemann-Trautmann

Synchronization errors, such as insertions and deletions, present a fundamental challenge in DNA-based data storage systems, arising from both synthesis and sequencing noise. These channels are often modeled as…

Information Theory · Computer Science 2025-06-23 Ziv Aharoni , Henry D. Pfister

A number of methods have been proposed over the last decade for encoding information using deoxyribonucleic acid (DNA), giving rise to the emerging area of DNA data embedding. Since a DNA sequence is conceptually equivalent to a sequence of…

Information Theory · Computer Science 2014-10-09 Félix Balado

Due to their sequential nature, traditional DNA synthesis methods are expensive in terms of time and resources. They also fabricate multiple copies of the same strand, introducing redundancy. This redundancy can be leveraged to enhance the…

Information Theory · Computer Science 2025-10-29 Frederik Walter , Yonatan Yehezkeally

Due to its longevity and enormous information density, DNA is an attractive medium for archival storage. In this work, we study the fundamental limits and trade-offs of DNA-based storage systems by introducing a new channel model, which we…

Information Theory · Computer Science 2020-01-20 Ilan Shomorony , Reinhard Heckel

This work presents a theoretical analysis of the probability of successfully retrieving data encoded with MDS codes (e.g., Reed-Solomon codes) in DNA storage systems. We study this probability under independent and identically distributed…

Information Theory · Computer Science 2026-05-08 Serge Kas Hanna

Digital information can be encoded in the building-block sequence of macro-molecules, such as RNA and single-stranded DNA. Methods of "writing" and "reading" macromolecular strands are currently available, but they are slow and expensive.…

Emerging Technologies · Computer Science 2017-09-14 Masud Mansuripur , Pramod Khulbe

We show that the Extrinsic Information about the coded bits of any good (capacity achieving) code operating over a wide class of discrete memoryless channels (DMC) is zero when channel capacity is below the code rate and positive constant…

Information Theory · Computer Science 2007-07-13 Michael Peleg , Amichai Sanderovich , Shlomo Shamai

A method for encoding information in DNA sequences is described. The method is based on the precision-resolution framework, and is aimed to work in conjunction with a recently suggested terminator-free template independent DNA synthesis…

Information Theory · Computer Science 2020-05-14 Siddharth Jain , Farzad Farnoud , Moshe Schwartz , Jehoshua Bruck

In this paper, we propose a novel iterative encoding algorithm for DNA storage to satisfy both the GC balance and run-length constraints using a greedy algorithm. DNA strands with run-length more than three and the GC balance ratio far from…

Information Theory · Computer Science 2023-01-04 Seong-Joon Park , Yongwoo Lee , Jong-Seon No