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The clinical application of patient-specific modelling of the heart can provide valuable insights in supplementing and advancing methods of diagnosis as well as helping to devise the best possible therapeutic approach for each individual…

Medical Physics · Physics 2023-08-03 Sebastian Skatulla , Carlo Sansour , Mary Familusi , Jagir Hussan , Ntobeko Ntusi

While ventricular electromechanics is extensively studied, four-chamber heart models have only been addressed recently; most of these works however neglect atrial contraction. Indeed, as atria are characterized by a complex physiology…

The Extracellular-Membrane-Intracellular (EMI) model is a novel mathematical framework for cardiac electrophysiology simulations. The EMI model provides a more detailed description of the heart's electrical activity compared to traditional…

Numerical Analysis · Mathematics 2025-04-29 Carlos Ballesteros , Alexei Cheviakov , Raymond J. Spiteri

The finite element method (FEM) is commonly used in computational cardiac simulations. For this method, a mesh is constructed to represent the geometry and, subsequently, to approximate the solution. To accurately capture curved geometrical…

Computing the solution of linear systems of equations is invariably the most time consuming task in the numerical solutions of PDEs in many fields of computational science. In this study, we focus on the numerical simulation of…

Computational Physics · Physics 2019-01-24 Jongmin Seo , Daniele E. Schiavazzi , Alison L. Marsden

The rapid developments in advanced sensing and imaging bring about a data-rich environment, facilitating the effective modeling, monitoring, and control of complex systems. For example, the body-sensor network captures multi-channel…

Machine Learning · Computer Science 2022-02-01 Jianxin Xie , Bing Yao

The eikonal equation has become an indispensable tool for modeling cardiac electrical activation accurately and efficiently. In principle, by matching clinically recorded and eikonal-based electrocardiograms (ECGs), it is possible to build…

Optimization and Control · Mathematics 2023-12-06 Thomas Grandits , Jan Verhülsdonk , Gundolf Haase , Alexander Effland , Simone Pezzuto

In this work we tackle the reconstruction of discontinuous coefficients in a semilinear elliptic equation from the knowledge of the solution on the boundary of the domain, an inverse problem motivated by biological application in cardiac…

Analysis of PDEs · Mathematics 2017-12-20 Elena Beretta , Luca Ratti , Marco Verani

Recent developments in elastic shape analysis (ESA) are motivated by the fact that it provides comprehensive frameworks for simultaneous registration, deformation, and comparison of shapes. These methods achieve computational efficiency…

Graphics · Computer Science 2019-06-18 Hamid Laga , Qian Xie , Ian H. Jermyn , Anuj Srivastava

Recent developments in imaging techniques and correlation algorithms enable measurement of strain fields on a deforming material at high spatial and temporal resolution. In such cases, the computation of the stress field from the known…

Materials Science · Physics 2020-12-08 Benjamin Cameron , Cem Tasan

We introduce a framework for performing the inverse imaging of composite elastic materials. Our technique uses surface acoustic wave (SAW) boundary observations within a minimization problem to express the interior composition of the…

Numerical Analysis · Mathematics 2019-03-15 Elliott Ginder , Riku Kanai

Computational models of cardiac structure and function are increasingly central to the development of subject-specific cardiac digital twins, enabling improved characterization of contractile dysfunction, pathological remodeling, and…

The field of cardiac electrophysiology tries to abstract, describe and finally model the electrical characteristics of a heartbeat. With recent advances in cardiac electrophysiology, models have become more powerful and descriptive as ever.…

Medical Physics · Physics 2022-12-16 Thomas Grandits , Simone Pezzuto , Gernot Plank

This paper presents the first application of the direct parametrisation method for invariant manifolds to a fully coupled multiphysics problem involving the nonlinear vibrations of deformable structures subjected to an electrostatic field.…

Numerical Analysis · Mathematics 2023-12-25 Attilio Frangi , Alessio Colombo , Alessandra Vizzaccaro , Cyril Touzé

Electrical Impedance Tomography (EIT) is a powerful imaging modality widely used in medical diagnostics, industrial monitoring, and environmental studies. The EIT inverse problem is about inferring the internal conductivity distribution of…

Image and Video Processing · Electrical Eng. & Systems 2025-08-11 Alexander Denker , Fabio Margotti , Jianfeng Ning , Kim Knudsen , Derick Nganyu Tanyu , Bangti Jin , Andreas Hauptmann , Peter Maass

A classical problem in elasticity theory involves an inhomogeneity embedded in a material of given stress and shear moduli. The inhomogeneity is a region of arbitrary shape whose stress and shear moduli differ from those of the surrounding…

Materials Science · Physics 2009-11-13 Joachim Mathiesen , Itamar Procaccia , Ido Regev

Locally resonant elastic metamaterials (LREM) can be designed, by optimizing the geometry of the constituent self-repeating unit cells, to potentially damp out vibration in selected frequency ranges, thus yielding desired bandgaps. However,…

Computational Engineering, Finance, and Science · Computer Science 2021-07-27 Manaswin Oddiraju , Amir Behjat , Mostafa Nouh , Souma Chowdhury

The efficient construction of anatomical models is one of the major challenges of patient-specific in-silico models of the human heart. Current methods frequently rely on linear statistical models, allowing no advanced topological changes,…

Image and Video Processing · Electrical Eng. & Systems 2024-05-24 Jan Verhülsdonk , Thomas Grandits , Francisco Sahli Costabal , Thomas Pinetz , Rolf Krause , Angelo Auricchio , Gundolf Haase , Simone Pezzuto , Alexander Effland

Electrical Impedance Tomography (EIT) is a powerful imaging technique with diverse applications, e.g., medical diagnosis, industrial monitoring, and environmental studies. The EIT inverse problem is about inferring the internal conductivity…

Machine Learning · Computer Science 2023-10-31 Derick Nganyu Tanyu , Jianfeng Ning , Andreas Hauptmann , Bangti Jin , Peter Maass

Learning neural operators on heterogeneous and irregular geometries remains a fundamental challenge, as existing approaches typically rely on structured discretisations or explicit mappings to a shared reference domain. We propose a unified…