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Diffusion and flow-based generative models have shown strong potential for image restoration. However, image denoising under unknown and varying noise conditions remains challenging, because the learned vector fields may become inconsistent…

Computer Vision and Pattern Recognition · Computer Science 2026-04-06 Jigang Duan , Genwei Ma , Xu Jiang , Wenfeng Xu , Ping Yang , Xing Zhao

Positron Emission Tomography (PET) is an essential technique in many clinical applications that allows for quantitative imaging at the molecular level. This study aims to develop a denoising method using novel dilated convolutional neural…

Medical Physics · Physics 2021-01-27 Karl Spuhler , Mario Serrano-Sosa , Renee Cattell , Christine DeLorenzo , Chuan Huang

Dose reduction in computed tomography (CT) is essential for decreasing radiation risk in clinical applications. Iterative reconstruction is one of the most promising ways to compensate for the increased noise due to reduction of photon…

Image and Video Processing · Electrical Eng. & Systems 2021-03-24 Zhuonan He , Yikun Zhang , Yu Guan , Shanzhou Niu , Yi Zhang , Yang Chen , Qiegen Liu

Cone-beam computed tomography (CBCT) is widely used in image-guided radiotherapy. Reconstructing CBCTs from limited-angle acquisitions (LA-CBCT) is highly desired for improved imaging efficiency, dose reduction, and better mechanical…

Medical Physics · Physics 2024-04-10 Jiacheng Xie , Hua-Chieh Shao , Yunxiang Li , You Zhang

Fluorescence lifetime imaging microscopy (FLIM) systems are limited by their slow processing speed, low signal-to-noise ratio (SNR), and expensive and challenging hardware setups. In this work, we demonstrate applying a denoising…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Varun Mannam , Yide Zhang , Xiaotong Yuan , Takashi Hato , Pierre C. Dagher , Evan L. Nichols , Cody J. Smith , Kenneth W. Dunn , Scott Howard

Due to various physical degradation factors and limited counts received, PET image quality needs further improvements. The denoising diffusion probabilistic models (DDPM) are distribution learning-based models, which try to transform a…

Image and Video Processing · Electrical Eng. & Systems 2022-09-15 Kuang Gong , Keith A. Johnson , Georges El Fakhri , Quanzheng Li , Tinsu Pan

Denoising diffusion probabilistic models have transformed image generation with their impressive fidelity and diversity. We show that they also excel in estimating optical flow and monocular depth, surprisingly, without task-specific…

Computer Vision and Pattern Recognition · Computer Science 2023-12-07 Saurabh Saxena , Charles Herrmann , Junhwa Hur , Abhishek Kar , Mohammad Norouzi , Deqing Sun , David J. Fleet

Fourier ptychographic microscopy (FPM) is a novel computational coherent imaging technique for high space-bandwidth product imaging. Mathematically, Fourier ptychographic (FP) reconstruction can be implemented as a phase retrieval…

Computer Vision and Pattern Recognition · Computer Science 2016-07-19 Liheng Bian , Jinli Suo , Jaebum Chung , Xiaoze Ou , Changhuei Yang , Feng Chen , Qionghai Dai

Reducing the radiation dose in computed tomography (CT) is important to mitigate radiation-induced risks. One option is to employ a well-trained model to compensate for incomplete information and map sparse-view measurements to the CT…

Image and Video Processing · Electrical Eng. & Systems 2023-03-29 Xiaoyue Li , Kai Shang , Gaoang Wang , Mark D. Butala

To obtain high-quality positron emission tomography (PET) scans while reducing radiation exposure to the human body, various approaches have been proposed to reconstruct standard-dose PET (SPET) images from low-dose PET (LPET) images. One…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Zeyu Han , Yuhan Wang , Luping Zhou , Peng Wang , Binyu Yan , Jiliu Zhou , Yan Wang , Dinggang Shen

Radiomics is an active area of research in medical image analysis, the low reproducibility of radiomics has limited its applicability to clinical practice. This issue is especially prominent when radiomic features are calculated from noisy…

Quantitative Methods · Quantitative Biology 2021-08-16 Junhua Chen , Chong Zhang , Alberto Traverso , Ivan Zhovannik , Andre Dekker , Leonard Wee , Inigo Bermejo

Dataset distillation compresses large datasets into compact synthetic sets with comparable performance in training models. Despite recent progress on diffusion-based distillation, this type of method typically depends on heuristic guidance…

Machine Learning · Computer Science 2026-02-06 Xuhui Li , Zhengquan Luo , Xiwei Liu , Yongqiang Yu , Zhiqiang Xu

Diffusion models achieve state-of-the-art image generation but remain computationally costly due to iterative denoising. Latent-space models like Stable Diffusion reduce overhead yet lose fine detail, while retrieval-augmented methods…

Machine Learning · Computer Science 2025-12-23 Bilal Faye , Hanane Azzag , Mustapha Lebbah

In recent years, deformable medical image registration techniques have made significant progress. However, existing models still lack efficiency in parallel extraction of coarse and fine-grained features. To address this, we construct a new…

Computer Vision and Pattern Recognition · Computer Science 2025-05-12 Ying Zhang , Shuai Guo , Chenxi Sun , Yuchen Zhu , Jinhai Xiang

Supervised deep learning methods have shown promise in undersampled Magnetic Resonance Imaging (MRI) reconstruction, but their requirement for paired data limits their generalizability to the diverse MRI acquisition parameters. Recently,…

Image and Video Processing · Electrical Eng. & Systems 2024-06-12 Wei Jiang , Zhuang Xiong , Feng Liu , Nan Ye , Hongfu Sun

Modeling physical systems in a generative manner offers several advantages, including the ability to handle partial observations, generate diverse solutions, and address both forward and inverse problems. Recently, diffusion models have…

Machine Learning · Computer Science 2025-05-29 Yi Zhang , Difan Zou

Diffusion Models (DMs) utilize an iterative denoising process to transform random noise into synthetic data. Initally proposed with a UNet structure, DMs excel at producing images that are virtually indistinguishable with or without…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Yuewei Yang , Jialiang Wang , Xiaoliang Dai , Peizhao Zhang , Hongbo Zhang

Neurological Positron Emission Tomography (PET) is a critical imaging modality for diagnosing and studying neurodegenerative diseases like Alzheimer's disease. However, the inherent low spatial resolution of PET images poses significant…

Medical Physics · Physics 2025-02-24 Matthew Tivnan , Quanzheng Li

In recent years, it has become popular to tackle image restoration tasks with a single pretrained diffusion model (DM) and data-fidelity guidance, instead of training a dedicated deep neural network per task. However, such "zero-shot"…

Computer Vision and Pattern Recognition · Computer Science 2025-04-07 Tomer Garber , Tom Tirer

Positron Emission Tomography (PET) is a vital imaging modality widely used in clinical diagnosis and preclinical research but faces limitations in image resolution and signal-to-noise ratio due to inherent physical degradation factors.…

Image and Video Processing · Electrical Eng. & Systems 2024-11-11 Boxiao Yu , Kuang Gong