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Accurately discriminating progressive stages of Alzheimer's Disease (AD) is crucial for early diagnosis and prevention. It often involves multiple imaging modalities to understand the complex pathology of AD, however, acquiring a complete…

Image and Video Processing · Electrical Eng. & Systems 2025-03-06 Seunghun Baek , Jaeyoon Sim , Guorong Wu , Won Hwa Kim

Mild cognitive impairment (MCI) is often at high risk of progression to Alzheimer's disease (AD). Existing works to identify the progressive MCI (pMCI) typically require MCI subtype labels, pMCI vs. stable MCI (sMCI), determined by whether…

Image and Video Processing · Electrical Eng. & Systems 2024-01-24 Chenhui Wang , Yiming Lei , Tao Chen , Junping Zhang , Yuxin Li , Hongming Shan

Labeled data is a fundamental component in training supervised deep learning models for computer vision tasks. However, the labeling process, especially for ordinal image classification where class boundaries are often ambiguous, is prone…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Alireza Sedighi Moghaddam , Mohammad Reza Mohammadi

Dynamic treatment regimens (DTRs) are sequential decision rules tailored at each stage by potentially time-varying patient features and intermediate outcomes observed in previous stages. The complexity, patient heterogeneity and chronicity…

Methodology · Statistics 2016-11-09 Ying Liu , Yuanjia Wang , Michael R. Kosorok , Yingqi Zhao , Donglin Zeng

Modern systems that rely on Machine Learning (ML) for predictive modelling, may suffer from the cold-start problem: supervised models work well but, initially, there are no labels, which are costly or slow to obtain. This problem is even…

Machine Learning · Computer Science 2021-10-25 Ricardo Barata , Miguel Leite , Ricardo Pacheco , Marco O. P. Sampaio , João Tiago Ascensão , Pedro Bizarro

Many real-world datasets are labeled with natural orders, i.e., ordinal labels. Ordinal regression is a method to predict ordinal labels that finds a wide range of applications in data-rich domains, such as natural, health and social…

Machine Learning · Computer Science 2020-04-28 Lu Wang , Dongxiao Zhu

Online Active Learning (OAL) aims to manage unlabeled datastream by selectively querying the label of data. OAL is applicable to many real-world problems, such as anomaly detection in health-care and finance. In these problems, there are…

Machine Learning · Computer Science 2019-11-19 Yifan Zhang , Peilin Zhao , Shuaicheng Niu , Qingyao Wu , Jiezhang Cao , Junzhou Huang , Mingkui Tan

Modeling a system's temporal behaviour in reaction to external stimuli is a fundamental problem in many areas. Pure Machine Learning (ML) approaches often fail in the small sample regime and cannot provide actionable insights beyond…

Machine Learning · Computer Science 2021-06-18 Zhaozhi Qian , William R. Zame , Lucas M. Fleuren , Paul Elbers , Mihaela van der Schaar

Learning with reduced labeling standards, such as noisy label, partial label, and multiple label candidates, which we generically refer to as \textit{imprecise} labels, is a commonplace challenge in machine learning tasks. Previous methods…

Machine Learning · Computer Science 2024-10-31 Hao Chen , Ankit Shah , Jindong Wang , Ran Tao , Yidong Wang , Xing Xie , Masashi Sugiyama , Rita Singh , Bhiksha Raj

Precision medicine is of considerable interest in clinical, academic and regulatory parties. The key to precision medicine is the optimal treatment regime. Recently, Zhou et al. (2017) developed residual weighted learning (RWL) to construct…

Methodology · Statistics 2017-11-30 Xin Zhou , Michael R. Kosorok

Objective: We aimed to develop and validate a novel multimodal framework HiMAL (Hierarchical, Multi-task Auxiliary Learning) framework, for predicting cognitive composite functions as auxiliary tasks that estimate the longitudinal risk of…

Machine Learning · Computer Science 2026-02-06 Sayantan Kumar , Sean Yu , Andrew Michelson , Thomas Kannampallil , Philip Payne

Pool-based active learning (AL) is a promising technology for increasing data-efficiency of machine learning models. However, surveys show that performance of recent AL methods is very sensitive to the choice of dataset and training…

Machine Learning · Computer Science 2023-09-12 Tim Bakker , Herke van Hoof , Max Welling

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

Ordinal regression (OR) is classification of ordinal data in which the underlying categorical target variable has a natural ordinal relation for the underlying explanatory variable. For $K$-class OR tasks, threshold methods learn a…

Machine Learning · Computer Science 2024-05-22 Ryoya Yamasaki , Toshiyuki Tanaka

Model-based deep learning methods that combine imaging physics with learned regularization priors have been emerging as powerful tools for parallel MRI acceleration. The main focus of this paper is to determine the utility of the monotone…

Machine Learning · Computer Science 2023-04-05 Aniket Pramanik , Mathews Jacob

Learning from noisy ordinal labels is a key challenge in medical imaging. In this work, we ask whether ordinal disease progression labels (better, worse, or stable) can be used to learn a representation allowing to classify disease state.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Gustav Schmidt , Holger Heidrich , Philipp Berens , Sarah Müller

Deep learning models have been successfully used in medical image analysis problems but they require a large amount of labeled images to obtain good performance.Deep learning models have been successfully used in medical image analysis…

Computer Vision and Pattern Recognition · Computer Science 2018-10-02 Asim Smailagic , Hae Young Noh , Pedro Costa , Devesh Walawalkar , Kartik Khandelwal , Mostafa Mirshekari , Jonathon Fagert , Adrián Galdrán , Susu Xu

Ordinal regression is commonly formulated as a multi-class problem with ordinal constraints. The challenge of designing accurate classifiers for ordinal regression generally increases with the number of classes involved, due to the large…

Machine Learning · Computer Science 2015-03-18 Chun-Wei Seah , Ivor W. Tsang , Yew-Soon Ong

An interpretable machine learning (ML) framework is introduced to enhance the diagnosis of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) by ensuring robustness of the ML models' interpretations. The dataset used comprises…

Active learning (AL) is a learning paradigm where an active learner has to train a model (e.g., a classifier) which is in principal trained in a supervised way, but in AL it has to be done by means of a data set with initially unlabeled…

Machine Learning · Computer Science 2015-12-23 Adrian Calma , Tobias Reitmaier , Bernhard Sick , Paul Lukowicz , Mark Embrechts
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