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Imaging genetics aims to uncover the hidden relationship between imaging quantitative traits (QTs) and genetic markers (e.g. single nucleotide polymorphism (SNP)), and brings valuable insights into the pathogenesis of complex diseases, such…

Methodology · Statistics 2025-04-30 Zhibin Pu , Shufei Ge

Alzheimer's disease is the most common cause of dementia, yet hard to diagnose precisely without invasive techniques, particularly at the onset of the disease. This work approaches image analysis and classification of synthetic…

Image and Video Processing · Electrical Eng. & Systems 2017-12-05 Wellington Pinheiro dos Santos , Ricardo Emmanuel de Souza , Plínio B. dos Santos Filho

Alzheimer's disease (AD) is an irreversible devastative neurodegenerative disorder associated with progressive impairment of memory and cognitive functions. Its early diagnosis is crucial for the development of possible future treatment…

Computer Vision and Pattern Recognition · Computer Science 2020-04-07 Ahsan Bin Tufail , Qiu-Na Zhang , Yong-Kui Ma

Generative modeling frameworks have emerged as an effective approach to capture high-dimensional image distributions from large datasets without requiring domain-specific knowledge, a capability essential for longitudinal disease…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 Ayantika Das , Arunima Sarkar , Keerthi Ram , Mohanasankar Sivaprakasam

The widespread use of multisensor technology and the emergence of big datasets have created the need to develop tools to reduce, approximate, and classify large and multimodal data such as higher-order tensors. While early approaches…

Numerical Analysis · Computer Science 2018-07-03 Alp Ozdemir , Ali Zare , Mark A. Iwen , Selin Aviyente

Visualizing and interpreting convolutional neural networks (CNNs) is an important task to increase trust in automatic medical decision making systems. In this study, we train a 3D CNN to detect Alzheimer's disease based on structural MRI…

Computer Vision and Pattern Recognition · Computer Science 2018-12-07 Johannes Rieke , Fabian Eitel , Martin Weygandt , John-Dylan Haynes , Kerstin Ritter

Recent neuroimaging studies that focus on predicting brain disorders via modern machine learning approaches commonly include a single modality and rely on supervised over-parameterized models.However, a single modality provides only a…

The aim of this paper is to develop a class of spatial transformation models (STM) to spatially model the varying association between imaging measures in a three-dimensional (3D) volume (or 2D surface) and a set of covariates. Our STMs…

Applications · Statistics 2016-07-27 Michelle F. Miranda , Hongtu Zhu , Joseph G. Ibrahim

Over 30 papers have proposed to use convolutional neural network (CNN) for AD classification from anatomical MRI. However, the classification performance is difficult to compare across studies due to variations in components such as…

This work introduces a tensor-based method to perform supervised classification on spatiotemporal data processed in an echo state network. Typically when performing supervised classification tasks on data processed in an echo state network,…

Machine Learning · Computer Science 2017-08-25 Ashley Prater

There is a growing interest to get a fully MR based radiotherapy. The most important development needed is to obtain improved bone tissue estimation. The existing model-based methods perform poorly on bone tissues. This paper was aimed at…

Applications · Statistics 2019-04-02 Fekadu L. Bayisa , Jun Yu

Exploring the application of deep learning technologies in the field of medical diagnostics, Magnetic Resonance Imaging (MRI) provides a unique perspective for observing and diagnosing complex neurodegenerative diseases such as Alzheimer…

Image and Video Processing · Electrical Eng. & Systems 2024-03-26 Shaojie Li , Haichen Qu , Xinqi Dong , Bo Dang , Hengyi Zang , Yulu Gong

Deep learning has been successful in predicting neurodegenerative disorders, such as Alzheimer's disease, from magnetic resonance imaging (MRI). Combining multiple imaging modalities, such as T1-weighted (T1) and diffusion-weighted imaging…

Artificial Intelligence · Computer Science 2026-01-30 Abhijith Shaji , Tamoghna Chattopadhyay , Sophia I. Thomopoulos , Greg Ver Steeg , Paul M. Thompson , Jose-Luis Ambite

Marginal Structural Models (MSM) are the most popular models for causal inference from time-series observational data. However, they have two main drawbacks: (a) they do not capture subject heterogeneity, and (b) they only consider fixed…

Machine Learning · Computer Science 2020-10-19 Debmalya Mandal , David Parkes

A central goal of modern magnetic resonance imaging (MRI) is to reduce the time required to produce high-quality images. Efforts have included hardware and software innovations such as parallel imaging, compressed sensing, and deep…

Medical Physics · Physics 2023-03-27 Yihong Xu , Chad W. Farris , Stephan W. Anderson , Xin Zhang , Keith A. Brown

We propose to apply a 2D CNN architecture to 3D MRI image Alzheimer's disease classification. Training a 3D convolutional neural network (CNN) is time-consuming and computationally expensive. We make use of approximate rank pooling to…

Computer Vision and Pattern Recognition · Computer Science 2021-01-14 Xin Xing , Gongbo Liang , Hunter Blanton , Muhammad Usman Rafique , Chris Wang , Ai-Ling Lin , Nathan Jacobs

The willingness to trust predictions formulated by automatic algorithms is key in a vast number of domains. However, a vast number of deep architectures are only able to formulate predictions without an associated uncertainty. In this…

Image and Video Processing · Electrical Eng. & Systems 2022-09-28 Matteo Ferrante , Tommaso Boccato , Nicola Toschi

Background: Dementia, marked by cognitive decline, is a global health challenge. Alzheimer's disease (AD), the leading type, accounts for ~70% of cases. Electroencephalography (EEG) measures show promise in identifying AD risk, but…

Signal Processing · Electrical Eng. & Systems 2024-11-28 Veronica Henao Isaza , David Aguillon , Carlos Andres Tobon Quintero , Francisco Lopera , John Fredy Ochoa Gomez

Machine Learning (ML) has emerged as a promising approach in healthcare, outperforming traditional statistical techniques. However, to establish ML as a reliable tool in clinical practice, adherence to best practices regarding data…

Image and Video Processing · Electrical Eng. & Systems 2023-09-15 Rosanna Turrisi , Alessandro Verri , Annalisa Barla

From a practical perspective, proposals are one of the main bottleneck for any Markov Chain Monte Carlo (MCMC) algorithm. This paper suggests a novel data driven or informed proposal for reversible jump MCMC for Bayesian variable selection…

Applications · Statistics 2025-01-14 Djidenou Montcho , Daiane Zuanetti , Thierry Chekouo , Luis Milan
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