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The Bayesian statistical framework provides a systematic approach to enhance the regularization model by incorporating prior information about the desired solution. For the Bayesian linear inverse problems with Gaussian noise and Gaussian…

Numerical Analysis · Mathematics 2024-05-21 Haibo Li

Recent advances in molecular biology allow the quantification of the transcriptome and scoring transcripts as differentially or equally expressed between two biological conditions. Although these two tasks are closely linked, the available…

Methodology · Statistics 2017-02-08 Panagiotis Papastamoulis , Magnus Rattray

Spatial transcriptomics clustering is pivotal for identifying cell subpopulations by leveraging spatial location information. While recent graph-based methods modeling cell-cell interactions have improved clustering accuracy, they remain…

Machine Learning · Computer Science 2026-01-21 Chenkai Guo , Yikai Zhu , Renxiang Guan , Jinli Ma , Siwei Wang , Ke Liang , Guangdun Peng , Dayu Hu

Spatial proteomics maps protein distributions in tissues, providing transformative insights for life sciences. However, current sequencing-based technologies suffer from low spatial resolution, and substantial inter-tissue variability in…

Quantitative Methods · Quantitative Biology 2025-08-26 Bokai Zhao , Weiyang Shi , Hanqing Chao , Zijiang Yang , Yiyang Zhang , Ming Song , Tianzi Jiang

We present clustering methods for multivariate data exploiting the underlying geometry of the graphical structure between variables. As opposed to standard approaches that assume known graph structures, we first estimate the edge structure…

Methodology · Statistics 2015-09-28 Sayantan Banerjee , Rehan Akbani , Veerabhadran Baladandayuthapani

Several modern genomic technologies, such as DNA-Methylation arrays, measure spatially registered probes that number in the hundreds of thousands across multiplechromosomes. The measured probes are by themselves less interesting…

Applications · Statistics 2016-11-16 John Nagorski , Genevera I. Allen

The paper presents a novel approach for unsupervised techniques in the field of clustering. A new method is proposed to enhance existing literature models using the proper Bayesian bootstrap to improve results in terms of robustness and…

Machine Learning · Statistics 2024-09-16 Federico Maria Quetti , Silvia Figini , Elena ballante

Bayesian Positive Source Separation (BPSS) is a useful unsupervised approach for hyperspectral data unmixing, where numerical non-negativity of spectra and abundances has to be ensured, such in remote sensing. Moreover, it is sensible to…

Earth and Planetary Astrophysics · Physics 2010-12-17 Frederic Schmidt , Albrecht Schmidt , Erwan Treguier , Mael Guiheneuf , Said Moussaoui , Nicolas Dobigeon

This work relates the framework of model-based clustering for spatial functional data where the data are surfaces. We first introduce a Bayesian spatial spline regression model with mixed-effects (BSSR) for modeling spatial function data.…

Methodology · Statistics 2015-08-05 Faicel Chamroukhi

With the rapid advancement of Spatial Resolved Transcriptomics (SRT) technology, it is now possible to comprehensively measure gene transcription while preserving the spatial context of tissues. Spatial domain identification and gene…

Genomics · Quantitative Biology 2024-08-14 Donghai Fang , Fangfang Zhu , Dongting Xie , Wenwen Min

Subspace clustering is the problem of clustering data that lie close to a union of linear subspaces. In the abstract form of the problem, where no noise or other corruptions are present, the data are assumed to lie in general position…

Computer Vision and Pattern Recognition · Computer Science 2020-02-13 Manolis C. Tsakiris , Rene Vidal

Bayesian neural networks (BNNs) provide a formalism to quantify and calibrate uncertainty in deep learning. Current inference approaches for BNNs often resort to few-sample estimation for scalability, which can harm predictive performance,…

Machine Learning · Computer Science 2024-02-14 Zhe Zeng , Guy Van den Broeck

Motivation: Understanding the spatial architecture of tissues is essential for decoding the complex interactions within cellular ecosystems and their implications for disease pathology and clinical outcomes. Recent advances in multiplex…

Quantitative Methods · Quantitative Biology 2025-04-28 Junsouk Choi , Jian Kang , Veerabhadran Baladandayuthapani

Sparse subspace clustering (SSC), as one of the most successful subspace clustering methods, has achieved notable clustering accuracy in computer vision tasks. However, SSC applies only to vector data in Euclidean space. As such, there is…

Computer Vision and Pattern Recognition · Computer Science 2016-03-08 Ming Yin , Yi Guo , Junbin Gao , Zhaoshui He , Shengli Xie

Cluster analysis relates to the task of assigning objects into groups which ideally present some desirable characteristics. When a cluster structure is confined to a subset of the feature space, traditional clustering techniques face…

Machine Learning · Statistics 2026-04-14 Efthymios Costa , Ioanna Papatsouma , Angelos Markos

Low-Rank Representation (LRR) highly suffers from discarding the locality information of data points in subspace clustering, as it may not incorporate the data structure nonlinearity and the non-uniform distribution of observations over the…

Machine Learning · Computer Science 2022-03-09 Eysan Mehrbani , Mohammad Hossein Kahaei , Seyed Aliasghar Beheshti

Subspace clustering has become widely adopted for the unsupervised analysis of hyperspectral images (HSIs). Recent model-aware deep subspace clustering methods often use a two-stage framework, involving the calculation of a…

Computer Vision and Pattern Recognition · Computer Science 2025-06-16 Xianlu Li , Nicolas Nadisic , Shaoguang Huang , Nikos Deligiannis , Aleksandra Pižurica

We introduce a Bayesian non-parametric spatial factor analysis model with spatial dependency induced through a prior on factor loadings. For each column of the loadings matrix, spatial dependency is encoded using a probit stick-breaking…

Methodology · Statistics 2019-11-12 Samuel I. Berchuck , Mark Janko , Felipe A. Medeiros , William Pan , Sayan Mukherjee

Spectral clustering is one of the most effective clustering approaches that capture hidden cluster structures in the data. However, it does not scale well to large-scale problems due to its quadratic complexity in constructing similarity…

Machine Learning · Computer Science 2019-11-26 Lingfei Wu , Pin-Yu Chen , Ian En-Hsu Yen , Fangli Xu , Yinglong Xia , Charu Aggarwal

The recovery of block-sparse signals with unknown structural patterns remains a fundamental challenge in structured sparse signal reconstruction. By proposing a variance transformation framework, this paper unifies existing pattern-based…

Optimization and Control · Mathematics 2026-04-13 Yanhao Zhang , Zhihan Zhu , Yong Xia