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Denoising diffusion probabilistic models (DDPMs) have pioneered new state-of-the-art results in disciplines such as computer vision and computational biology for diverse tasks ranging from text-guided image generation to structure-guided…

Machine Learning · Computer Science 2024-05-28 Alex Morehead , Jianlin Cheng

Transformer-based deep neural networks have revolutionized the field of molecular-related prediction tasks by treating molecules as symbolic sequences. These models have been successfully applied in various organic chemical applications by…

Chemical Physics · Physics 2023-11-14 Tatsuya Sagawa , Ryosuke Kojima

We present a novel learning-based approach for computing correspondences between non-rigid 3D shapes. Unlike previous methods that either require extensive training data or operate on handcrafted input descriptors and thus generalize poorly…

Machine Learning · Statistics 2020-04-01 Nicolas Donati , Abhishek Sharma , Maks Ovsjanikov

Predicting materials properties from composition or structure is of great interest to the materials science community. Deep learning has recently garnered considerable interest in materials predictive tasks with low model errors when…

Materials Science · Physics 2021-11-01 Chi Chen , Shyue Ping Ong

Geometric deep learning has demonstrated a great potential in non-Euclidean data analysis. The incorporation of geometric insights into learning architecture is vital to its success. Here we propose a curvature-enhanced graph convolutional…

Quantitative Methods · Quantitative Biology 2023-06-27 Cong Shen , Pingjian Ding , Junjie Wee , Jialin Bi , Jiawei Luo , Kelin Xia

Machine learning has the potential to automate molecular design and drastically accelerate the discovery of new functional compounds. Towards this goal, generative models and reinforcement learning (RL) using string and graph…

Machine Learning · Computer Science 2022-02-02 Daniel Flam-Shepherd , Alexander Zhigalin , Alán Aspuru-Guzik

Graph matching aims to establish correspondences between vertices of graphs such that both the node and edge attributes agree. Various learning-based methods were recently proposed for finding correspondences between image key points based…

Computer Vision and Pattern Recognition · Computer Science 2022-05-10 Zhenzhang Ye , Tarun Yenamandra , Florian Bernard , Daniel Cremers

Why and how that deep learning works well on different tasks remains a mystery from a theoretical perspective. In this paper we draw a geometric picture of the deep learning system by finding its analogies with two existing geometric…

Machine Learning · Computer Science 2017-10-31 Xiao Dong , Jiasong Wu , Ling Zhou

Recent research has shown that mmWave radar sensing is effective for object detection in low visibility environments, which makes it an ideal technique in autonomous navigation systems such as autonomous vehicles. However, due to the…

Image and Video Processing · Electrical Eng. & Systems 2021-09-21 Yue Sun , Honggang Zhang , Zhuoming Huang , Benyuan Liu

Bimanual manipulation requires policies that can reason about 3D geometry, anticipate how it evolves under action, and generate smooth, coordinated motions. However, existing methods typically rely on 2D features with limited spatial…

Computer Vision and Pattern Recognition · Computer Science 2026-03-02 Chongyang Xu , Haipeng Li , Shen Cheng , Jingyu Hu , Haoqiang Fan , Ziliang Feng , Shuaicheng Liu

We present an exploration of machine learning architectures for predicting brain responses to realistic images on occasion of the Algonauts Challenge 2023. Our research involved extensive experimentation with various pretrained models.…

Neurons and Cognition · Quantitative Biology 2023-09-20 Riccardo Chimisso , Sathya Buršić , Paolo Marocco , Giuseppe Vizzari , Dimitri Ognibene

Antibody-antigen interactions play a crucial role in identifying and neutralizing harmful foreign molecules. In this paper, we investigate the optimal representation for predicting the binding sites in the two molecules and emphasize the…

Biomolecules · Quantitative Biology 2023-07-26 Marco Pegoraro , Clémentine Dominé , Emanuele Rodolà , Petar Veličković , Andreea Deac

Generative models, especially diffusion models (DMs), have achieved promising results for generating feature-rich geometries and advancing foundational science problems such as molecule design. Inspired by the recent huge success of Stable…

Machine Learning · Computer Science 2023-05-03 Minkai Xu , Alexander Powers , Ron Dror , Stefano Ermon , Jure Leskovec

Molecular representation learning has attracted much attention recently. A molecule can be viewed as a 2D graph with nodes/atoms connected by edges/bonds, and can also be represented by a 3D conformation with 3-dimensional coordinates of…

Machine Learning · Computer Science 2022-07-20 Jinhua Zhu , Yingce Xia , Lijun Wu , Shufang Xie , Tao Qin , Wengang Zhou , Houqiang Li , Tie-Yan Liu

In this work, we present a novel learning-based framework that combines the local accuracy of contrastive learning with the global consistency of geometric approaches, for robust non-rigid matching. We first observe that while contrastive…

Computer Vision and Pattern Recognition · Computer Science 2022-09-19 Lei Li , Souhaib Attaiki , Maks Ovsjanikov

Geometric phases play a crucial role in diverse fields. In chemistry they appear when a reaction path encircles an intersection between adiabatic potential energy surfaces and the molecular wavefunction experiences quantum-mechanical…

Quantum Physics · Physics 2024-02-05 Rocco Martinazzo , Irene Burghardt

We apply a temporal edge prediction model for weighted dynamic graphs to predict time-dependent changes in molecular structure. Each molecule is represented as a complete graph in which each atom is a vertex and all vertex pairs are…

Machine Learning · Computer Science 2021-06-28 Michael Hunter Ashby , Jenna A. Bilbrey

Hydrogen atom transfer (HAT) reactions are essential in many biological processes, such as radical migration in damaged proteins, but their mechanistic pathways remain incompletely understood. Simulating HAT is challenging due to the need…

Machine Learning · Computer Science 2025-11-25 Marlen Neubert , Patrick Reiser , Frauke Gräter , Pascal Friederich

Mapping the chemical reaction pathways and their corresponding activation barriers is a significant challenge in molecular simulation. Given the inherent complexities of 3D atomic geometries, even generating an initial guess of these paths…

Computational Physics · Physics 2025-01-24 Akihide Hayashi , So Takamoto , Ju Li , Yuta Tsuboi , Daisuke Okanohara

Interoperability issue is a significant problem in Building Information Modeling (BIM). Object type, as a kind of critical semantic information needed in multiple BIM applications like scan-to-BIM and code compliance checking, also suffers…

Computer Vision and Pattern Recognition · Computer Science 2022-12-05 Hairong Luo , Ge Gao , Han Huang , Ziyi Ke , Cheng Peng , Ming Gu
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