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Diagnosis and treatment guidance are aided by detecting relevant biomarkers in medical images. Although supervised deep learning can perform accurate segmentation of pathological areas, it is limited by requiring a-priori definitions of…

Diabetic Retinopathy (DR) is a leading cause of vision loss worldwide, requiring early detection to preserve sight. Limited access to physicians often leaves DR undiagnosed. To address this, AI models utilize lesion segmentation for…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Shivum Telang

Optical Coherence Tomography (OCT) is a widely used non-invasive biomedical imaging modality that can rapidly provide volumetric images of samples. Here, we present a deep learning-based image reconstruction framework that can generate…

Image and Video Processing · Electrical Eng. & Systems 2021-07-30 Yijie Zhang , Tairan Liu , Manmohan Singh , Yilin Luo , Yair Rivenson , Kirill V. Larin , Aydogan Ozcan

Automatic retinal layer segmentation with medical images, such as optical coherence tomography (OCT) images, serves as an important tool for diagnosing ophthalmic diseases. However, it is challenging to achieve accurate segmentation due to…

Image and Video Processing · Electrical Eng. & Systems 2024-04-26 Xiang He , Weiye Song , Yiming Wang , Fabio Poiesi , Ji Yi , Manishi Desai , Quanqing Xu , Kongzheng Yang , Yi Wan

Age-related macular degeneration (AMD) and choroidal neovascularization (CNV)-related conditions are leading causes of vision loss worldwide, with optical coherence tomography (OCT) serving as a cornerstone for early detection and…

Computer Vision and Pattern Recognition · Computer Science 2026-02-26 Erfan Nourbakhsh , Nasrin Sanjari , Ali Nourbakhsh

Purpose: This study is to test the feasibility of optical coherence tomography (OCT) detection of photoreceptor abnormality and to verify the photoreceptor abnormality is rod predominated in early DR . Methods: OCT images were acquired from…

Quantitative Methods · Quantitative Biology 2021-12-16 David Le , Taeyoon Son , Jennifer I. Lim , Xincheng Yao

Recent advancements in retinal surgery have paved the way for a modern operating room equipped with a surgical robot, a microscope, and intraoperative optical coherence tomography (iOCT)- a depth sensor widely used in retinal surgery.…

In this paper, we propose a novel retinal layer boundary model for segmentation of optical coherence tomography (OCT) images. The retinal layer boundary model consists of 9 open parametric contours representing the 9 retinal layers in OCT…

Computer Vision and Pattern Recognition · Computer Science 2018-08-10 Jinming Duan , Weicheng Xie , Ryan Wen Liu , Christopher Tench , Irene Gottlob , Frank Proudlock , Li Bai

This study is to demonstrate deep learning for automated artery-vein (AV) classification in optical coherence tomography angiography (OCTA). The AV-Net, a fully convolutional network (FCN) based on modified U-shaped CNN architecture,…

Image and Video Processing · Electrical Eng. & Systems 2020-06-09 Minhaj Alam , David Le , Taeyoon Son , Jennifer I. Lim , Xincheng Yao

Retinal vessel segmentation is a crucial step in diagnosing and screening various diseases, including diabetes, ophthalmologic diseases, and cardiovascular diseases. In this paper, we propose an effective and efficient method for vessel…

Image and Video Processing · Electrical Eng. & Systems 2020-09-24 Zhun Fan , Jiajie Mo , Benzhang Qiu , Wenji Li , Guijie Zhu , Chong Li , Jianye Hu , Yibiao Rong , Xinjian Chen

A new formulation of lateral imaging process of point-scanning optical coherence tomography (OCT) and a new differential contrast method designed by using this formulation are presented. The formulation is based on a mathematical sample…

Recent advancements in medical image analysis have led to the development of highly specialized models tailored to specific clinical tasks. These models have demonstrated exceptional performance and remain a crucial research direction. Yet,…

Computer Vision and Pattern Recognition · Computer Science 2025-06-19 Alessio Negrini , Simon Reiß

Diabetic eye disease is one of the fastest growing causes of preventable blindness. With the advent of anti-VEGF (vascular endothelial growth factor) therapies, it has become increasingly important to detect center-involved diabetic macular…

Early detection of cancer is crucial for treatment and overall patient survival. In the upper aerodigestive tract (UADT) the gold standard for identification of malignant tissue is an invasive biopsy. Recently, non-invasive imaging…

Computer Vision and Pattern Recognition · Computer Science 2019-10-10 Nils Gessert , Matthias Schlüter , Sarah Latus , Veronika Volgger , Christian Betz , Alexander Schlaefer

To develop a new method to quantify nonperfused retinal capillaries (NPCs) by using co-registered optical coherence tomography (OCT) and OCT angiography (OCTA), and to evaluate NPCs in eyes with age-related macular degeneration (AMD) and…

Quantitative Methods · Quantitative Biology 2024-11-11 Min Gao , Yukun Guo , Tristan T. Hormel , Jie Wang , Elizabeth White , Dong-Wouk Park , Thomas S. Hwang , Steven T. Bailey , Yali Jia

Optical coherence tomography (OCT) microscope (OCM) uses a high-numerical-aperture objective to achieve cellular-level lateral resolution. However, its practical imaging depth range is limited by the depth of focus (DOF). Although…

In this chapter a general mathematical model of Optical Coherence Tomography (OCT) is presented on the basis of the electromagnetic theory. OCT produces high resolution images of the inner structure of biological tissues. Images are…

Numerical Analysis · Mathematics 2016-04-19 Peter Elbau , Leonidas Mindrinos , Otmar Scherzer

Optical coherence tomography (OCT) is a popular modality in ophthalmology and is also used intravascularly. Our interest in this work is OCT in the context of airway abnormalities in infants and children where the high resolution of OCT and…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Yining Jiao , Amy Oldenburg , Yinghan Xu , Srikamal Soundararajan , Carlton Zdanski , Julia Kimbell , Marc Niethammer

Recent Alzheimer's disease (AD) patient studies have focused on retinal analysis, as the retina is the only part of the central nervous system which can be imaged non-invasively by optical methods. However as this is a relatively new…

The choroid, a highly vascular layer behind the retina, is an extension of the central nervous system and has parallels with the renal cortex, with blood flow far exceeding that of the brain and kidney. Thus, there has been growing interest…

Image and Video Processing · Electrical Eng. & Systems 2025-02-12 Jamie Burke
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