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Motivated by cutting-edge applications like cryo-electron microscopy (cryo-EM), the Multi-Reference Alignment (MRA) model entails the learning of an unknown signal from repeated measurements of its images under the latent action of a group…

Statistics Theory · Mathematics 2022-03-11 Subhro Ghosh , Philippe Rigollet

Motivated by the problem of determining the atomic structure of macromolecules using single-particle cryo-electron microscopy (cryo-EM), we study the sample and computational complexities of the sparse multi-reference alignment (MRA) model:…

Information Theory · Computer Science 2021-09-27 Tamir Bendory , Oscar Mickelin , Amit Singer

Multi-reference alignment (MRA) is the problem of recovering a signal from its multiple noisy copies, each acted upon by a random group element. MRA is mainly motivated by single-particle cryo-electron microscopy (cryo-EM) that has recently…

Information Theory · Computer Science 2023-08-15 Tamir Bendory , Dan Edidin

Motivated by single-particle cryo-electron microscopy, multi-reference alignment (MRA) models the task of recovering an unknown signal from multiple noisy observations corrupted by random rotations. The standard approach,…

Signal Processing · Electrical Eng. & Systems 2026-01-09 Shay Kreymer , Amnon Balanov , Tamir Bendory

The multi-reference alignment (MRA) problem entails estimating an image from multiple noisy and rotated copies of itself. If the noise level is low, one can reconstruct the image by estimating the missing rotations, aligning the images, and…

Signal Processing · Electrical Eng. & Systems 2022-06-17 Noam Janco , Tamir Bendory

Multireference alignment (MRA) problem is to estimate an underlying signal from a large number of noisy circularly-shifted observations. The existing methods are always proposed under the hypothesis of a single Gaussian noise. However, the…

Optimization and Control · Mathematics 2021-07-23 Cuicui Zhao , Jun Liu , Xinqi Gong

We consider parameter estimation under sparse linear regression -- an extensively studied problem in high-dimensional statistics and compressed sensing. While the minimax framework has been one of the most fundamental approaches for…

Statistics Theory · Mathematics 2025-01-24 Shubhangi Ghosh , Yilin Guo , Haolei Weng , Arian Maleki

We are motivated by problems that arise in a number of applications such as Online Marketing and Explosives detection, where the observations are usually modeled using Poisson statistics. We model each observation as a Poisson random…

Machine Learning · Statistics 2016-06-29 Mohammad H. Rohban , Delaram Motamedvaziri , Venkatesh Saligrama

We study the multi-reference alignment (MRA) problem of recovering a signal from noisy observations acted on by unknown random circular shifts. While the information-theoretic limits of MRA are well characterized in many settings, the…

Signal Processing · Electrical Eng. & Systems 2026-02-12 Amnon Balanov , Wasim Huleihel , Tamir Bendory

Multireference alignment (MRA) is the problem of estimating a signal from many noisy and cyclically shifted copies of itself. In this paper, we consider an extension called heterogeneous MRA, where $K$ signals must be estimated, and each…

Information Theory · Computer Science 2018-02-02 Nicolas Boumal , Tamir Bendory , Roy R. Lederman , Amit Singer

Motivated by structural biology applications, we study the projected multi-reference alignment (MRA) model, in which an unknown signal is observed through noisy samples, each generated by applying a random cyclic shift followed by a fixed…

Signal Processing · Electrical Eng. & Systems 2026-05-26 Amnon Balanov , Josh Katz , Tamir Bendory , Dan Edidin

The growing role of data-driven approaches to scientific discovery has unveiled a large class of models that involve latent transformations with a rigid algebraic constraint. Three-dimensional molecule reconstruction in Cryo-Electron…

Information Theory · Computer Science 2019-06-04 Amelia Perry , Jonathan Weed , Afonso S. Bandeira , Philippe Rigollet , Amit Singer

Multireference alignment (MRA) refers to the problem of recovering a signal from noisy samples subject to random circular shifts. Expectation--maximization (EM) and variational approaches use statistical modeling to achieve high accuracy at…

Information Theory · Computer Science 2025-10-30 Vahid Shahverdi , Emanuel Ström , Joakim Andén

In this paper, we study a new notion of scaled minimaxity for sparse estimation in high-dimensional linear regression model. We present more optimistic lower bounds than the one given by the classical minimax theory and hence improve on…

Statistics Theory · Mathematics 2018-10-15 Mohamed Ndaoud

The most frequently used condition for sampling matrices employed in compressive sampling is the restricted isometry (RIP) property of the matrix when restricted to sparse signals. At the same time, imposing this condition makes it…

Information Theory · Computer Science 2013-03-11 Alexander Barg , Arya Mazumdar , Rongrong Wang

In this paper, we propose a sparse signal estimation algorithm that is suitable for many wireless communication systems, especially for the future millimeter wave and underwater communication systems. This algorithm is not only…

Information Theory · Computer Science 2018-07-20 Chongwen Huang , Lei Liu , Chau Yuen

In the multireference alignment model, a signal is observed by the action of a random circular translation and the addition of Gaussian noise. The goal is to recover the signal's orbit by accessing multiple independent observations. Of…

Information Theory · Computer Science 2018-11-06 Emmanuel Abbe , Tamir Bendory , William Leeb , João Pereira , Nir Sharon , Amit Singer

Since its development, the minimax framework has been one of the corner stones of theoretical statistics, and has contributed to the popularity of many well-known estimators, such as the regularized M-estimators for high-dimensional…

Statistics Theory · Mathematics 2024-01-01 Yilin Guo , Haolei Weng , Arian Maleki

In nonlinear deterministic parameter estimation, the maximum likelihood estimator (MLE) is unable to attain the Cramer-Rao lower bound at low and medium signal-to-noise ratios (SNR) due the threshold and ambiguity phenomena. In order to…

Applications · Statistics 2015-06-19 Achraf Mallat , Sinan Gezici , Davide Dardari , Christophe Craeye , Luc Vandendorpe

In this paper, we discuss application of iterative Stochastic Optimization routines to the problem of sparse signal recovery from noisy observation. Using Stochastic Mirror Descent algorithm as a building block, we develop a multistage…

Machine Learning · Statistics 2022-03-31 Anatoli Juditsky , Andrei Kulunchakov , Hlib Tsyntseus
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