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Information transmission in biological signaling circuits has often been described using the metaphor of a noise filter. Cellular systems need accurate, real-time data about their environmental conditions, but the biochemical reaction…

Molecular Networks · Quantitative Biology 2019-02-27 David Hathcock , James Sheehy , Casey Weisenberger , Efe Ilker , Michael Hinczewski

After being considered as a nuisance to be filtered out, it became recently clear that biochemical noise plays a complex role, often fully functional, for a genetic network. The influence of intrinsic and extrinsic noises on genetic…

Molecular Networks · Quantitative Biology 2015-06-05 Giulio Caravagna , Giancarlo Mauri , Alberto d'Onofrio

Stochastic resonance is a phenomenon in which noise enhances the response of a system to an input signal. The brain is an example of a system that has to detect and transmit signals in a noisy environment, suggesting that it is a good…

Neurons and Cognition · Quantitative Biology 2017-10-16 Bertha Vázquez-Rodríguez , Andrea Avena-Koenigsberger , Olaf Sporns , Alessandra Griffa , Patric Hagmann , Hernán Larralde

Gene regulatory circuits must contend with intrinsic noise that arises due to finite numbers of proteins. While some circuits act to reduce this noise, others appear to exploit it. A striking example is the competence circuit in Bacillus…

Molecular Networks · Quantitative Biology 2016-04-27 Andrew Mugler , Mark Kittisopikul , Luke Hayden , Jintao Liu , Chris H. Wiggins , Gurol M. Suel , Aleksandra M. Walczak

The two-way capacities of quantum channels determine the ultimate entanglement and secret-key distribution rates achievable by two distant parties that are connected by a noisy transmission line, in absence of quantum repeaters. Since…

Quantum Physics · Physics 2025-01-27 Francesco Anna Mele , Ludovico Lami , Vittorio Giovannetti

We present a scattering theory description for the inelastic current noise in the presence of electron-vibration interactions. In this description, we specify elastic and inelastic scattering contributions to the shot noise by examining…

Mesoscale and Nanoscale Physics · Physics 2017-09-15 Sejoong Kim

We evaluate the mutual information between the input and the output of a two layer network in the case of a noisy and non-linear analogue channel. In the case where the non-linearity is small with respect to the variability in the noise, we…

Statistical Mechanics · Physics 2009-10-31 E. Korutcheva , V. Del Prete , J. -P. Nadal

Neurons in the central nervous system are affected by complex and noisy signals due to fluctuations in their cellular environment and in the inputs they receive from many other cells 1,2. Such noise usually increases the probability that a…

Neurons and Cognition · Quantitative Biology 2008-05-06 Boris S. Gutkin , Juergen Jost , Henry C. Tuckwell

A recurring motif in gene regulatory networks is transcription factors (TFs) that regulate each other, and then bind to overlapping sites on DNA, where they interact and synergistically control transcription of a target gene. Here, we…

Molecular Networks · Quantitative Biology 2013-03-07 Sahand Hormoz

We study and analyze the fundamental aspects of noise propagation in recurrent as well as deep, multi-layer networks. The main focus of our study are neural networks in analogue hardware, yet the methodology provides insight for networks in…

Emerging Technologies · Computer Science 2020-06-29 Nadezhda Semenova , Xavier Porte , Louis Andreoli , Maxime Jacquot , Laurent Larger , Daniel Brunner

Several studies highlighted the relevance of extrinsic noise in shaping cell decision making and differentiation in molecular networks. Experimental evidences of phenotypic differentiation are given by the presence of bimodal distributions…

Molecular Networks · Quantitative Biology 2017-04-19 Marco Del Giudice , Stefano Bo , Silvia Grigolon , Carla Bosia

Using a stochastic generalization of the Hodgkin–Huxley model, we consider the influence of intrinsic channel noise on the synchronization between the spiking activity of the excitable membrane and an externally applied periodic…

Biological Physics · Physics 2007-05-23 Gerhard Schmid , Igor Goychuk , Peter Hanggi

Neurons are subject to various kinds of noise. In addition to synaptic noise, the stochastic opening and closing of ion channels represents an intrinsic source of noise that affects the signal processing properties of the neuron. In this…

Neurons and Cognition · Quantitative Biology 2008-11-14 Yong Chen , Lianchun Yu , Shao-Meng Qin

Recent experiments indicate a connection between the low- and high-frequency noise affecting superconducting quantum systems. We explore the possibilities that both noises can be produced by one ensemble of microscopic modes, made up, e.g.,…

Mesoscale and Nanoscale Physics · Physics 2007-05-23 Alexander Shnirman , Gerd Schön , Ivar Martin , Yuriy Makhlin

Using the formalism of information theory, we analyze the mechanism of information transduction in a simple one-step signaling cascade S$\rightarrow$X representing the gene regulatory network. Approximating the signaling channel to be…

Molecular Networks · Quantitative Biology 2018-11-14 Mintu Nandi , Ayan Biswas , Suman K Banik , Pinaki Chaudhury

We investigate channel synthesis in a cascade setting where nature provides an iid sequence $X^n$ at node 1. Node 1 can send a message at rate $R_1$ to node 2 and node 2 can send a message at rate $R_2$ to node 3. Additionally, all 3 nodes…

Information Theory · Computer Science 2013-05-21 Sanket Satpathy , Paul Cuff

Complex systems are characterized by multiple spatial and temporal scales. A natural framework to capture their multiscale nature is that of multilayer networks, where different layers represent distinct physical processes that often…

Statistical Mechanics · Physics 2024-04-29 Giorgio Nicoletti , Daniel Maria Busiello

Noise-induced population bursting has been widely identified to play important roles in the information process. We constructed a mathematical model for a random and sparse neural network where bursting can be induced from the resting state…

Neurons and Cognition · Quantitative Biology 2021-09-10 Na Yu , Gurpreet Jagdev , Michelle Morgovsky

In this paper, we investigate the impact of noise on a simplified trained convolutional network. The types of noise studied originate from a real optical implementation of a neural network, but we generalize these types to enhance the…

Adaptation and Self-Organizing Systems · Physics 2025-06-24 Ivan Kolesnikov , Nadezhda Semenova

Many biological, technological, and social systems can be effectively described as networks of interacting subsystems. Typically, these networks are not isolated objects, but interact with their environment through both signals and…

Systems and Control · Electrical Eng. & Systems 2026-01-06 Amirhossein Nazerian , Malbor Asllani , Melvyn Tyloo , Wai Lim Ku , Francesco Sorrentino