English
Related papers

Related papers: Could dropping a few cells change the takeaways fr…

200 papers

The use of multiple Decision Models (DMs) enables to enhance the accuracy in decisions and at the same time allows users to evaluate the confidence in decision making. In this paper we explore the ability of multiple DMs to learn from a…

Artificial Intelligence · Computer Science 2008-05-27 Vitaly Schetinin , Dayou Li , Carsten Maple

Motivation: Human genomic datasets often contain sensitive information that limits use and sharing of the data. In particular, simple anonymisation strategies fail to provide sufficient level of protection for genomic data, because the data…

Quantitative Methods · Quantitative Biology 2019-08-27 Teppo Niinimäki , Mikko Heikkilä , Antti Honkela , Samuel Kaski

In classification applications, we often want probabilistic predictions to reflect confidence or uncertainty. Dropout, a commonly used training technique, has recently been linked to Bayesian inference, yielding an efficient way to quantify…

Machine Learning · Computer Science 2019-06-25 Zhilu Zhang , Adrian V. Dalca , Mert R. Sabuncu

In this work, we introduce Y-Drop, a regularization method that biases the dropout algorithm towards dropping more important neurons with higher probability. The backbone of our approach is neuron conductance, an interpretable measure of…

Machine Learning · Computer Science 2024-09-17 Efthymios Georgiou , Georgios Paraskevopoulos , Alexandros Potamianos

Integrating heterogeneous datasets across different measurement platforms is a fundamental challenge in many scientific applications. A common example arises in deconvolution problems, such as cell type deconvolution, where one aims to…

Methodology · Statistics 2025-09-30 Dongyue Xie , Lin Gui , Jingshu Wang

Background: The availability of high throughput methods for measurement of mRNA concentrations makes the reliability of conclusions drawn from the data and global quality control of samples and hybridization important issues. We address…

Quantitative Methods · Quantitative Biology 2007-05-23 S. Bilke , T. Breslin , M. Sigvardsson

DNA microarray experiments, a well-established experimental technique, aim at understanding the function of genes in some biological processes. One of the most common experiments in functional genomics research is to compare two groups of…

Methodology · Statistics 2007-08-22 Javier Cabrera , Ching-Ray Yu

While variational dropout approaches have been shown to be effective for network sparsification, they are still suboptimal in the sense that they set the dropout rate for each neuron without consideration of the input data. With such…

Machine Learning · Statistics 2019-03-05 Juho Lee , Saehoon Kim , Jaehong Yoon , Hae Beom Lee , Eunho Yang , Sung Ju Hwang

Existing ML models are known to be highly over-parametrized, and use significantly more resources than required for a given task. Prior work has explored compressing models offline, such as by distilling knowledge from larger models into…

Machine Learning · Computer Science 2022-05-17 Julian Knodt

Graphical models have gained a lot of attention recently as a tool for learning and representing dependencies among variables in multivariate data. Often, domain scientists are looking specifically for differences among the dependency…

Machine Learning · Statistics 2013-07-11 Diane Oyen , Alexandru Niculescu-Mizil , Rachel Ostroff , Alex Stewart , Vincent P. Clark

We propose a novel modular debiasing technique applicable to any discrete random source, addressing the fundamental challenge of reliably extracting high-quality randomness from inherently imperfect physical processes. The method involves…

Data Analysis, Statistics and Probability · Physics 2025-05-12 Eduardo Gueron

A vast array of transformative technologies developed over the past decade has enabled measurement and perturbation at ever increasing scale, yet our understanding of many systems remains limited by experimental capacity. Overcoming this…

Quantitative Methods · Quantitative Biology 2020-12-25 Brian Cleary , Aviv Regev

Grokking, or delayed generalization, is an intriguing learning phenomenon where test set loss decreases sharply only after a model's training set loss has converged. This challenges conventional understanding of the training dynamics in…

Machine Learning · Computer Science 2025-02-05 Breno W. Carvalho , Artur S. d'Avila Garcez , Luís C. Lamb , Emílio Vital Brazil

An interesting phenomenon arises: Empirical Risk Minimization (ERM) sometimes outperforms methods specifically designed for out-of-distribution tasks. This motivates an investigation into the reasons behind such behavior beyond algorithmic…

Machine Learning · Computer Science 2026-01-21 Hong Zheng , Fei Teng

Dropout is a widely used regularization technique in deep learning, but its effects are typically realized through stochastic masking rather than explicit optimization objectives. We propose a deterministic formulation that expresses…

Machine Learning · Computer Science 2026-04-23 Vidhi Agrawal , Illia Oleksiienko , Alexandros Iosifidis

Antimicrobial resistance is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050. Research over the last decade has demonstrated…

Quantitative Methods · Quantitative Biology 2020-09-24 K. Farquhar , H. Flohr , D. A. Charlebois

Dropout is used as a practical tool to obtain uncertainty estimates in large vision models and reinforcement learning (RL) tasks. But to obtain well-calibrated uncertainty estimates, a grid-search over the dropout probabilities is necessary…

Machine Learning · Statistics 2017-05-23 Yarin Gal , Jiri Hron , Alex Kendall

In genetic networks, information of relevance to the organism is represented by the concentrations of transcription factor molecules. In order to extract this information the cell must effectively "measure"' these concentrations, but there…

Molecular Networks · Quantitative Biology 2025-02-13 Marianne Bauer , Mariela D. Petkova , Thomas Gregor , Eric F. Wieschaus , William Bialek

Consider a researcher estimating the parameters of a regression function based on data for all 50 states in the United States or on data for all visits to a website. What is the interpretation of the estimated parameters and the standard…

Statistics Theory · Mathematics 2019-06-25 Alberto Abadie , Susan Athey , Guido W. Imbens , Jeffrey M. Wooldridge

As input data distributions evolve, the predictive performance of machine learning models tends to deteriorate. In practice, new input data tend to come without target labels. Then, state-of-the-art techniques model input data distributions…

Machine Learning · Computer Science 2023-09-08 Carlos Mougan , Klaus Broelemann , David Masip , Gjergji Kasneci , Thanassis Thiropanis , Steffen Staab