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The dynamic response of prestressed semiflexible biopolymers is characterized by the propagation and relaxation of tension, which arises due to the near inextensibility of a stiff backbone. It is coupled to the dynamics of contour length…

Soft Condensed Matter · Physics 2009-10-16 B. Obermayer , E. Frey

Branched actin networks exert pushing forces in eukaryotic cells, and adapt their stiffness to their environment. The physical basis for their mechanics and adaptability is however not understood. Indeed, here we show that their high…

Since the invention of polymer networks in the 19th century (e.g., crosslinked natural rubber by Goodyear), it has been a dogma that stiffer networks are less stretchable, a trade-off inherent to the molecular nature of polymer network…

Soft Condensed Matter · Physics 2024-05-13 Baiqiang Huang , Shifeng Nian , Li-Heng Cai

Recurrent neural networks are frequently studied in terms of their information-processing capabilities. The structural properties of these networks are seldom considered, beyond those emerging from the connectivity tuning necessary for…

Molecular Networks · Quantitative Biology 2025-02-20 Maria Sol Vidal-Saez , Jordi Garcia-Ojalvo

Geometric and structural constraints greatly restrict the selection of folds adapted by protein backbones, and yet, folded proteins show an astounding diversity in functionality. For structure to have any bearing on function, it is thus…

Biological Physics · Physics 2010-04-20 Brinda K. V. , Saraswathi Vishveshwara , Smitha Vishveshwara

As deep neural networks grow in size, from thousands to millions to billions of weights, the performance of those networks becomes limited by our ability to accurately train them. A common naive question arises: if we have a system with…

Machine Learning · Computer Science 2018-05-29 Nathan O. Hodas , Panos Stinis

In this research study, a numerical tool, which is based on a version of Slender Body theory, has been used and also modified to simulate the mechanical behaviour of single- and double-cross-linked biopolymer networks (hydrogel) under…

Soft Condensed Matter · Physics 2026-05-06 Nasrollah Hajaliakbari , David Head , Oliver Harlen

The mechanical properties of cells are dominated by the cytoskeleton, an interconnected network of long elastic filaments. The connections between the filaments are provided by crosslinking proteins, which constitute, next to the filaments,…

Soft Condensed Matter · Physics 2012-10-09 Claus Heussinger

Networks and dense suspensions frequently reside near a boundary between soft (or fluid-like) and rigid (or solid-like) regimes. Transitions between these regimes can be driven by changes in structure, density, or applied stress or strain.…

Soft Condensed Matter · Physics 2023-11-10 Jordan L. Shivers , Abhinav Sharma , Fred C. MacKintosh

Semiflexible biopolymer networks are commonly found in biological systems, from the cytoskeleton of cells to the extracellular matrix. Such networks often naturally occur as composites, in which various components interact to generate rich…

Soft Condensed Matter · Physics 2018-01-18 D. L. Humphries , J. A. Grogan , E. A. Gaffney

Artificial neural networks took a lot of inspiration from their biological counterparts in becoming our best machine perceptual systems. This work summarizes some of that history and incorporates modern theoretical neuroscience into…

Neural and Evolutionary Computing · Computer Science 2022-09-12 Robert Bain

Force transmission at large length scales is crucial for such biological functions as cell motility and morphogenesis. The networks that transmit these forces are malleable, patterned by active forces generated at the microscale by…

Biological Physics · Physics 2025-11-27 Kanaya Malakar , Albert Countryman , Bulbul Chakraborty

Pruning neural networks has regained interest in recent years as a means to compress state-of-the-art deep neural networks and enable their deployment on resource-constrained devices. In this paper, we propose a robust compressive learning…

Machine Learning · Computer Science 2020-06-05 George Retsinas , Athena Elafrou , Georgios Goumas , Petros Maragos

Modern deep networks have millions to billions of parameters, which leads to high memory and energy requirements during training as well as during inference on resource-constrained edge devices. Consequently, pruning techniques have been…

Machine Learning · Computer Science 2020-03-06 Sourjya Roy , Priyadarshini Panda , Gopalakrishnan Srinivasan , Anand Raghunathan

There has recently been an increasing desire to evaluate neural networks locally on computationally-limited devices in order to exploit their recent effectiveness for several applications; such effectiveness has nevertheless come together…

Machine Learning · Computer Science 2019-10-25 Hossein Baktash , Emanuele Natale , Laurent Viennot

Recurrent neural networks (RNNs) have recently achieved remarkable successes in a number of applications. However, the huge sizes and computational burden of these models make it difficult for their deployment on edge devices. A practically…

Machine Learning · Computer Science 2019-12-10 Liangjian Wen , Xuanyang Zhang , Haoli Bai , Zenglin Xu

Recent studies assessing the efficacy of pruning neural networks methods uncovered a surprising finding: when conducting ablation studies on existing pruning-at-initialization methods, namely SNIP, GraSP, SynFlow, and magnitude pruning,…

Machine Learning · Computer Science 2021-07-06 Sahib Singh , Rosanne Liu

Due to their unique structural and mechanical properties, randomly-crosslinked polymer networks play an important role in many different fields, ranging from cellular biology to industrial processes. In order to elucidate how these…

Transient networks comprised of polymers connected by short-lived bonds are a common design theme for both biological and synthetic materials. Transient bonds can provide mechanical rigidity, while still allowing for visco-elastic flows on…

Soft Condensed Matter · Physics 2019-01-02 Yuval Mulla , Gijsje H. Koenderink

Deep neural networks have achieved increasingly accurate results on a wide variety of complex tasks. However, much of this improvement is due to the growing use and availability of computational resources (e.g use of GPUs, more layers, more…

Machine Learning · Computer Science 2018-08-03 Ini Oguntola , Subby Olubeko , Christopher Sweeney