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We present a Quality by Design (QbD) styled approach for optimizing lipid nanoparticle (LNP) formulations, aiming to offer scientists an accessible workflow. The inherent restriction in these studies, where the molar ratios of ionizable,…

Applications · Statistics 2023-11-14 Andrew T. Karl , Sean Essex , James Wisnowski , Heath Rushing

Wave impact loads on maritime structures can cause casualties, damage, pollution and operational delays. Consequently, their extreme values should be accounted for in the design of these structures. However, this is challenging, as wave…

Applications · Statistics 2026-04-23 Sanne M. van Essen , Harleigh C. Seyffert

We address the detection of emission reduction goals in corporate reports, an important task for monitoring companies' progress in addressing climate change. Specifically, we focus on the issue of integrating expert feedback in the form of…

Machine Learning · Computer Science 2025-07-02 Marco Wrzalik , Adrian Ulges , Anne Uersfeld , Florian Faust , Viola Campos

In a wide range of applications it is desirable to optimally control a dynamical system with respect to concurrent, potentially competing goals. This gives rise to a multiobjective optimal control problem where, instead of computing a…

Optimization and Control · Mathematics 2020-12-18 Sebastian Peitz , Sina Ober-Blöbaum , Michael Dellnitz

Building a predictive model that rapidly adapts to real-time condition monitoring (CM) signals is critical for engineering systems/units. Unfortunately, many current methods suffer from a trade-off between representation power and agility…

Machine Learning · Computer Science 2025-08-25 Seokhyun Chung , Raed Al Kontar

Model predictive control (MPC) is a powerful strategy for planning and control in autonomous mobile robot navigation. However, ensuring safety in real-world deployments remains challenging due to the presence of disturbances and measurement…

Robotics · Computer Science 2025-08-12 Dennis Benders , Johannes Köhler , Robert Babuška , Javier Alonso-Mora , Laura Ferranti

The Projection on Proper elements (PoPe) is a novel method of code control dedicated to 1) checking the correct implementation of models, 2) determining the convergence of numerical methods and 3) characterizing the residual errors of any…

Model-Based Systems Engineering aims at creating a model of a system under development, covering the complete system with a level of detail that allows to define and understand its behavior and enables to define any interface and…

Software Engineering · Computer Science 2022-01-19 Florian Schummer , Maximilian Hyba

Model monitoring is a critical component of the machine learning lifecycle, safeguarding against undetected drops in the model's performance after deployment. Traditionally, performance monitoring has required access to ground truth labels,…

Machine Learning · Computer Science 2026-03-10 Juhani Kivimäki , Jakub Białek , Wojtek Kuberski , Jukka K. Nurminen

This paper develops a novel sequential Monte Carlo (SMC) approach for joint state and parameter estimation that can deal efficiently with abruptly changing parameters which is a common case when tracking maneuvering targets. The approach…

Computation · Statistics 2015-10-12 Christopher Nemeth , Paul Fearnhead , Lyudmila Mihaylova

Shape optimization is a challenging task in many engineering fields, since the numerical solutions of parametric system may be computationally expensive. This work presents a novel optimization procedure based on reduced order modeling,…

Numerical Analysis · Mathematics 2018-11-07 Nicola Demo , Marco Tezzele , Gianluca Gustin , Gianpiero Lavini , Gianluigi Rozza

Autonomous docking remains one of the most challenging maneuvers in marine robotics, requiring precise control and robust perception in confined spaces. This paper presents a novel approach integrating Model Predictive Path Integral(MPPI)…

Robotics · Computer Science 2025-01-17 Akash Vijayakumar , Atmanand M A , Abhilash Somayajula

We present an optimization-based approach for trajectory planning and control of a maneuverable melting probe with a high number of binary control variables. The dynamics of the system are modeled by a set of ordinary differential equations…

Optimization and Control · Mathematics 2018-09-14 Christian Meerpohl , Kathrin Flaßkamp , Christof Büskens

A global optimization framework, acronymed COMBEO (Change OfMeasure Based Evolutionary Optimization), is proposed. An important aspect in the development is a set of derivative-free additive directional terms obtainable through a change of…

Methodology · Statistics 2014-11-10 Saikat Sarkar , Debasish Roy

In this paper, we address the identification problem for the systems characterized by linear time-invariant dynamics with bilinear observation models. More precisely, we consider a suitable parametric description of the system and formulate…

Systems and Control · Electrical Eng. & Systems 2025-02-24 Diyou Liu , Mohammad Khosravi

This paper presents a model predictive control (MPC) framework leveraging an ensemble of data-based models to optimally control complex systems under multiple operating conditions. A novel combination rule for ensemble models is proposed,…

Systems and Control · Electrical Eng. & Systems 2026-05-07 Laura Boca de Giuli , Samuel Mallick , Alessio La Bella , Azita Dabiri , Bart De Schutter , Riccardo Scattolini

In target tracking with mobile multi-sensor systems, sensor deployment impacts the observation capabilities and the resulting state estimation quality. Based on a partially observable Markov decision process (POMDP) formulation comprised of…

Multiagent Systems · Computer Science 2022-03-04 Tianqi Li , Lucas W. Krakow , Swaminathan Gopalswamy

Large-scale foundation models provide powerful feature representations for downstream object segmentation tasks. However, when adapted to specific tasks through the full-parameter fine-tuning, the enormous parameters being updated often…

Computer Vision and Pattern Recognition · Computer Science 2025-10-27 Yanguang Sun , Jiawei Lian , Jian Yang , Lei Luo

Nonlinear systems play a significant role in numerous scientific and engineering disciplines, and comprehending their behavior is crucial for the development of effective control and prediction strategies. This paper introduces a novel…

Systems and Control · Electrical Eng. & Systems 2023-08-15 Kaushal Kumar

A key challenge in tuning Model Predictive Control (MPC) cost function parameters is to ensure that the system performance stays consistently above a certain threshold. To address this challenge, we propose a novel method, COAT-MPC,…

Machine Learning · Computer Science 2025-03-25 Albert Gassol Puigjaner , Manish Prajapat , Andrea Carron , Andreas Krause , Melanie N. Zeilinger
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