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Purpose: In this study we investigate whether a Convolutional Neural Network (CNN) can generate clinically relevant parametric maps from CT perfusion data in a clinical setting of patients with acute ischemic stroke. Methods: Training of…

Image and Video Processing · Electrical Eng. & Systems 2021-01-18 Umberto A. Gava , Federico D'Agata , Enzo Tartaglione , Marco Grangetto , Francesca Bertolino , Ambra Santonocito , Edwin Bennink , Mauro Bergui

In this work, we present a novel convolutional neural net- work based method for perfusion map generation in dynamic suscepti- bility contrast-enhanced perfusion imaging. The proposed architecture is trained end-to-end and solely relies on…

Computer Vision and Pattern Recognition · Computer Science 2018-06-12 Andreas Hess , Raphael Meier , Johannes Kaesmacher , Simon Jung , Fabien Scalzo , David Liebeskind , Roland Wiest , Richard McKinley

Perfusion imaging plays a crucial role in acute stroke diagnosis and treatment decision making. Current perfusion analysis relies on deconvolution of the measured signals, an operation that is mathematically ill-conditioned and requires…

Computer Vision and Pattern Recognition · Computer Science 2018-10-12 David Robben , Paul Suetens

Dynamic susceptibility-weighted contrast-enhanced (DSC) MRI or perfusion-MRI plays an important role in the non-invasive assessment of tumor vascularity. However, the large number of images provided by the method makes display and…

General Physics · Physics 2007-11-20 Friso Hoefnagels , Keith S Cover , Ester Sanchez , Frank J. Lagerwaard

Dynamic computed tomography perfusion (CTP) imaging is a promising approach for acute ischemic stroke diagnosis and evaluation. Hemodynamic parametric maps of cerebral parenchyma are calculated from repeated CT scans of the first pass of…

Medical Physics · Physics 2020-05-21 Dufan Wu , Hui Ren , Quanzheng Li

More than 13 million people suffer from ischemic cerebral stroke worldwide each year. Thrombolytic treatment can reduce brain damage but has a narrow treatment window. Computed Tomography Perfusion imaging is a commonly used primary…

Image and Video Processing · Electrical Eng. & Systems 2021-04-22 Luca Tomasetti , Kjersti Engan , Mahdieh Khanmohammadi , Kathinka Dæhli Kurz

Perfusion MRI is an important modality in many brain imaging protocols, since it probes cerebrovascular changes in aging and many diseases; however, it may not be always available. Here we introduce a method that seeks to estimate regional…

Image and Video Processing · Electrical Eng. & Systems 2019-11-20 Ganesh B Chand , Mohamad Habes , Sudipto Dolui , John A Detre , David A Wolk , Christos Davatzikos

CT Perfusion (CTP) imaging has gained importance in the diagnosis of acute stroke. Conventional perfusion analysis performs a deconvolution of the measurements and thresholds the perfusion parameters to determine the tissue status. We…

This study aimed to propose a denoising method for dynamic contrast-enhanced computed tomography (DCE-CT) perfusion studies using a three-dimensional deep image prior (DIP), and to investigate its usefulness in comparison with total…

Medical Physics · Physics 2023-04-04 Kenya Murase

Simultaneous modeling of the spatio-temporal variation patterns of brain functional network from 4D fMRI data has been an important yet challenging problem for the field of cognitive neuroscience and medical image analysis. Inspired by the…

Computer Vision and Pattern Recognition · Computer Science 2021-03-24 Yu Zhao , Xiang Li , Wei Zhang , Shijie Zhao , Milad Makkie , Mo Zhang , Quanzheng Li , Tianming Liu

To shorten the door-to-puncture time for better treating patients with acute ischemic stroke, it is highly desired to obtain quantitative cerebral perfusion images using C-arm cone-beam computed tomography (CBCT) equipped in the…

Image and Video Processing · Electrical Eng. & Systems 2024-12-30 Haotian Zhao , Ruifeng Chen , Jing Yan , Juan Feng , Jun Xiang , Yang Chen , Dong Liang , Yinsheng Li

Perfusion imaging is crucial in acute ischemic stroke for quantifying the salvageable penumbra and irreversibly damaged core lesions. As such, it helps clinicians to decide on the optimal reperfusion treatment. In perfusion CT imaging,…

Image and Video Processing · Electrical Eng. & Systems 2022-04-27 Ezequiel de la Rosa , Diana M. Sima , Bjoern Menze , Jan S. Kirschke , David Robben

This work examines the hypothesis that intravoxel incoherent motion MRI (IVIM) can quantify local cerebral blood flow (qCBF), infarct volume, and define the ischemic penumbra for determination of the perfusion-diffusion mismatch (PWI/DWI)…

Clinical SPECT-MPI images of 345 patients acquired from a dedicated cardiac SPECT in list-mode format were retrospectively employed to predict normal-dose images from low-dose data at the half, quarter, and one-eighth-dose levels. A…

Background and Objective: This proof of concept study investigates mathematical modelling of blood flow and oxygen transport in cerebral microcirculation, focusing on understanding hemodynamic responses. By coupling oxygen transport models…

Numerical Analysis · Mathematics 2024-11-19 Maryam Samavaki , Santtu Söderholm , Arash Zarrin Nia , Sampsa Pursiainen

DSC-MRI perfusion is a medical imaging technique for diagnosing and prognosing brain tumors and strokes. Its analysis relies on mathematical deconvolution, but noise or motion artifacts in a clinical environment can disrupt this process,…

Quantitative Methods · Quantitative Biology 2025-10-17 Pierre Fayolle , Alexandre Bône , Noëlie Debs , Mathieu Naudin , Pascal Bourdon , Remy Guillevin , David Helbert

Perfusion imaging is the current gold standard for acute ischemic stroke analysis. It allows quantification of the salvageable and non-salvageable tissue regions (penumbra and core areas respectively). In clinical settings, the singular…

Image and Video Processing · Electrical Eng. & Systems 2021-04-01 Ezequiel de la Rosa , David Robben , Diana M. Sima , Jan S. Kirschke , Bjoern Menze

This paper demonstrates spherical convolutional neural networks (S-CNN) offer distinct advantages over conventional fully-connected networks (FCN) at estimating scalar parameters of tissue microstructure from diffusion MRI (dMRI). Such…

Image and Video Processing · Electrical Eng. & Systems 2022-08-17 Tobias Goodwin-Allcock , Jason McEwen , Robert Gray , Parashkev Nachev , Hui Zhang

Intravoxel Incoherent Motion (IVIM) is a non-contrast magnetic resonance imaging diffusion-based scan that uses a multitude of b-values to measure various speeds of molecular perfusion and diffusion, sidestepping inaccuracy of arterial…

Medical Physics · Physics 2025-01-22 M. Liu , N. Saadat , Y. Jeong , S. Roth , M. Niekrasz , M. Giurcanu , T. Carroll , G. Christoforidis

Purpose: Multi-expert deep learning training methods to automatically quantify ischemic brain tissue on Non-Contrast CT Materials and Methods: The data set consisted of 260 Non-Contrast CTs from 233 patients of acute ischemic stroke…

Computer Vision and Pattern Recognition · Computer Science 2024-03-26 Sophie Ostmeier , Brian Axelrod , Benjamin Pulli , Benjamin F. J. Verhaaren , Abdelkader Mahammedi , Yongkai Liu , Christian Federau , Greg Zaharchuk , Jeremy J. Heit
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