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Atmospheric pressure plasma jets (APPJ) are investigated as an efficient approach to induce antitumor effects of cancerous tissues without inducing any damage (e.g. dessication, burnings). For this, a two-steps methodology has been…

Medical Physics · Physics 2019-12-03 F. Judee , J. Vaquero , L. Fouassier , T. Dufour

Through the last decade, cold atmospheric plasma (CAP) has emerged as an innovative therapeutic option for cancer treatment. Recently, we have set up a potentially safe atmospheric pressure plasma jet device that displays antitumoral…

Two atmospheric pressure plasma jet devices - a plasma gun and a plasma Tesla jet - are compared in terms of safety and therapeutic efficiency to reduce the tumor volume progression of cholangiocarcinoma, i.e. a rare and very aggressive…

Applied Physics · Physics 2019-11-26 F. Judée , J. Vaquero , S. Guégan , L. Fouassier , T. Dufour

Cold atmospheric plasma (CAP) is a near room temperature ionized gas, generated under non-equilibrium discharge conditions. Here we show that a short exposure of rat peritoneal exudate macrophages and T-cells to CAP in vitro, triggered an…

Medical Physics · Physics 2022-02-01 Fengdong Cheng , Dayun Yan , Jie Chen , Zi Wang , Alex Horkowitz , Michael Keidar , Eduardo M. Sotomayor

Pan-microbial inactivation technologies that do not require high temperatures, reactive chemical compounds, or UV radiation could address gaps in current infection control strategies and provide efficient sterilization of biologics in the…

Cold atmospheric plasma (CAP) has been emerged as a novel technology for cancer treatment. CAP can directly treat cells and tissue but such direct application is limited to skin or can be invoked as a supplement during open surgery. In this…

Medical Physics · Physics 2016-12-21 Zhitong Chen , Xiaoqian Cheng , Li Lin , Michael Keidar

For years, extensive efforts have been made to discover effective, non-invasive anti-cancer therapies. Cold atmospheric plasma (CAP), is a near room temperature ionized gas composed of reactive species, charged particles, neutral particles,…

Cold atmospheric plasma (CAP) is a promising new agent for (selective) cancer treatment, but the underlying cause of the anti-cancer effect of CAP is not well understood yet. Among different theories and observations, one theory in…

Molecular Networks · Quantitative Biology 2020-10-28 Charlotta Bengtson , Annemie Bogaerts

Cold atmospheric plasma (CAP) was shown to affect cells not only directly, but also indirectly by means of plasma pre-treated solution. This study investigated a new application of CAP generated in deionized (DI) water for the cancer…

Medical Physics · Physics 2016-10-17 Zhitong Chen , Li Lin , Xiaoqian Cheng , Eda Gjika , Michael Keidar

This study aimed to investigate the antitumor effect of ultrasmall gold nanoparticles (AuNPs), around 3 nm, stabilized by the anionic polysaccharide gum arabic (GA-AuNPs). The focus was downregulation of cancer hallmarks of aggressive…

A new design of plasma source that merges the main features of capacitive dielectric barrier discharge (DBD) and cold atmospheric plasma jet (CAPJ) is discussed. The DBD system consists of a flexible, porous matrix consisting of silica…

Plasma Physics · Physics 2021-02-08 Carles Corbella , Sabine Portal , Li Lin , Michael Keidar

Plasma medicine is an emerging and innovative interdisciplinary research field combining biology, chemistry, physics, engineering, and medicine. However, the safe clinical application of cold atmospheric plasma (CAP) technology is still a…

Medical Physics · Physics 2023-05-31 Zhitong Chen , Richard Obenchain , Richard E. Wirz

Purpose: Pulsed-laser irradiation of light-absorbing gold nanoparticles (AuNPs) attached to cells transiently increases cell membrane permeability for targeted molecule delivery. Here, we targeted EGFR on the ovarian carcinoma cell line…

Biomolecules · Quantitative Biology 2018-10-09 Cuiping Yao , Florian Rudnitzki , Gereon Huettmann , Zhenxi Zhang , Ramtin Rahmanzadeh

The poor delivery of nanoparticles to target cancer cells hinders their success in the clinical setting. In this work, an alternative target readily available for circulating nanoparticles has been selected to eliminate the need for…

Biological Physics · Physics 2021-03-18 Juan L. Paris , Gonzalo Villaverde , Sergio Gomez-Grana , Maria Vallet-Regi

In recent years, cold atmospheric plasma (CAP) using inert gas has been successfully applied for biomedicine, such as sterilization, wound healing, skin diseases, and tumor treatment. Here, we reported air cold atmospheric plasma with three…

There are several methods to improve cancer patient survival rates by inducing hyperthermia in tumor tissues, which involves raising their temperature above 41{\deg}C. These methods utilize different energy sources to deliver heat to the…

Heat-based cancer treatment, so-called hyperthermia, can be used to destroy tumour cells directly or to make them more susceptible to chemotherapy or radiation therapy. To apply heat locally, iron oxide nanoparticles are injected into the…

Computational Engineering, Finance, and Science · Computer Science 2025-02-04 Barbara Wirthl , Paolo Decuzzi , Bernhard A. Schrefler , Wolfgang A. Wall

Photoinduced hyperthermia is a cancer therapy technique that induces death to cancerous cells via heat generated by plasmonic nanoparticles. While previous studies have shown that some nanoparticles can be effective at killing cancer cells…

Plasma sources suitable to generate low temperature plasmas has been fundamental for the advances in plasma medicine. In this research field, plasma sources must comply with stringent conditions for clinical applications. The main…

Micro-sized cold atmospheric plasma (uCAP) has been developed to expand the applications of CAP in cancer therapy. In this paper, uCAP devices with different nozzle lengths were applied to investigate effects on both brain (glioblastoma…

Tissues and Organs · Quantitative Biology 2018-04-24 Zhitong Chen , Li Lin , Qinmin Zheng , Jonathan H. Sherman , Jerome Canady , Barry Trink , Michael Keidar
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