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Collective behaviors in cellular systems are regulated not only by biochemical signalling pathways but also by intercellular mechanical forces, whose quantification in contractile monolayers remains poorly understood. Here, by integrating…

Quantitative Methods · Quantitative Biology 2025-10-30 Yucheng Huo , Kexin Guo , Massimo Paradiso , K. Jimmy Hsia

In topology optimization of compliant mechanisms, the specific placement of boundary conditions strongly affects the resulting material distribution and performance of the design. At the same time, the most effective locations of the loads…

Computational Engineering, Finance, and Science · Computer Science 2025-02-05 Lee R. Alacoque , Anurag Bhattacharyya , Kai A. James

Interfaces in tissues are ubiquitous, both between tissue and environment as well as between populations of different cell types. The propagation of an interface can be driven mechanically. % e.g. by a difference in the respective…

Tissues and Organs · Quantitative Biology 2024-06-03 Tobias Büscher , Angel L. Diez , Gerhard Gompper , Jens Elgeti

Cross slip of screw dislocations in crystalline solids is a stress-driven thermally activated process essential to many phenomena during plastic deformation, including dislocation pattern formation, strain hardening, and dynamic recovery.…

Materials Science · Physics 2023-03-14 Yifan Wang , Wei Cai

In pulsating active matter, topological defects are motile despite the absence of any macroscopic flows and microscopic self-propulsion. We reveal that this motility arises from a ratchet effect: the mechanochemical coupling between local…

Soft Condensed Matter · Physics 2026-05-26 Luca Casagrande , Alessandro Manacorda , Etienne Fodor

How do cells tune emergent properties at the scale of tissues? One class of such emergent behaviors are rigidity transitions, in which a tissue changes from a solid-like to a fluid-like state or vice versa. Here, we introduce a new way for…

Soft Condensed Matter · Physics 2025-06-04 Sadjad Arzash , Indrajit Tah , Andrea J. Liu , M. Lisa Manning

Topological defects in active liquid crystals can be confined by introducing gradients of activity. Here, we examine the dynamical behavior of two defects confined by a sharp gradient of activity that separates an active circular region and…

Soft Condensed Matter · Physics 2021-06-16 Ali Mozaffari , Rui Zhang , Noe Atzin , Juan J. de Pablo

To produce sounds, we adjust the tension of our vocal folds to shape their properties and control the pitch. This efficient mechanism offers inspiration for designing reconfigurable materials and adaptable soft robots. However,…

Soft Condensed Matter · Physics 2025-06-18 Alexandre Delory , Daniel A. Kiefer , Maxime Lanoy , Antonin Eddi , Claire Prada , Fabrice Lemoult

Active systems, from bacterial suspensions to cellular monolayers, are continuously driven out of equilibrium by local injection of energy from their constituent elements and exhibit turbulent-like and chaotic patterns. Here we demonstrate…

Soft Condensed Matter · Physics 2016-02-04 Amin Doostmohammadi , Michael F. Adamer , Sumesh P. Thampi , Julia M. Yeomans

Elastic strain has the potential for a controlled manipulation of the band gap and spin-polarized Dirac states of topological materials, which can lead to pseudo-magnetic-field effects, helical flat bands and topological phase transitions.…

An elastic disk is coated with an elastic rod, uniformly prestressed with a tensile or compressive axial force. The prestress state is assumed to be induced by three different models of external radial load or by 'shrink-fit' forcing the…

Classical Physics · Physics 2024-04-10 Matteo Gaibotti , Sofia G. Mogilevskaya , Andrea Piccolroaz , Davide Bigoni

Monolayers of anisotropic cells exhibit long-ranged orientational order and topological defects. During the development of organisms, orientational order often influences morphogenetic events. However, the linkage between the mechanics of…

Soft Condensed Matter · Physics 2021-01-20 Carles Blanch-Mercader , Pau Guillamat , Aurélien Roux , Karsten Kruse

Exact solutions are derived for the problem of a two-dimensional, infinitely anisotropic, linear-elastic medium containing a periodic lattice of voids. The matrix material possesses either one infinitely soft, or one infinitely hard loading…

Materials Science · Physics 2008-04-17 Francois Willot , Yves-Patrick Pellegrini , Pedro Ponte Castaneda

We investigate how material rigidity acts as a key control parameter for the failure of solids under stress. In both experiments and simulations, we demonstrate that material failure can be continuously tuned by varying the underlying…

Topological constraints have long been known to provide efficient mechanisms for localizing and storing energy across a range of length scales, from knots in DNA to turbulent plasmas. Despite recent theoretical and experimental progress on…

Soft Condensed Matter · Physics 2020-11-11 Vishal P. Patil , Žiga Kos , Miha Ravnik , Jörn Dunkel

Flexible strain sensors are critical to several potential intelligent applications, such as human-machine interfaces, soft robotics, human motion detection, and safety monitoring of components. Stretchable functional materials are important…

We present a novel, self-consistent and robust theoretical model to investigate elastic interactions between topological defects in liquid crystal shells. Accounting for the non-concentric nature of the shell in a simple manner, we are able…

Soft Condensed Matter · Physics 2016-12-14 Alexandre Darmon , Olivier Dauchot , Teresa Lopez-Leon , Michael Benzaquen

In recent years there has been renewed interest in the behavior of dislocations in crystals that exhibit strong atomic scale disorder, as typical of compositionally complex single phase alloys. The behavior of dislocations in such crystals…

Materials Science · Physics 2021-10-26 Aviral Vaid , De'an Wei , Erik Bitzek , Samaneh Nasiri , Michael Zaiser

Genomic DNA is constantly subjected to various mechanical stresses arising from its biological functions and cell packaging. If the local mechanical properties of DNA change under torsional and tensional stress, the activity of…

Biomolecules · Quantitative Biology 2015-05-28 Alexey K. Mazur

Molecular topology of polymers plays a key role in determining their physical properties. We studied herein the topological effects on the static and dynamic properties of a 2D catenated network of DNA rings called a kinetoplast.…

Soft Condensed Matter · Physics 2022-09-13 Indresh Yadav , Dana Al Sulaiman , Patrick S. Doyle