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Digitization of histology images and the advent of new computational methods, like deep learning, have helped the automatic grading of colorectal adenocarcinoma cancer (CRA). Present automated CRA grading methods, however, usually use tiny…

Computer Vision and Pattern Recognition · Computer Science 2021-07-13 Neda Zamanitajeddin , Mostafa Jahanifar , Nasir Rajpoot

Spatially resolved transcriptomics represents a significant advancement in single-cell analysis by offering both gene expression data and their corresponding physical locations. However, this high degree of spatial resolution entails a…

Genomics · Quantitative Biology 2024-03-19 Xiaoyu Li , Wenwen Min , Shunfang Wang , Changmiao Wang , Taosheng Xu

The task of spatial clustering of transcriptomics data is of paramount importance. It enables the classification of tissue samples into diverse subpopulations of cells, which, in turn, facilitates the analysis of the biological functions of…

Machine Learning · Computer Science 2025-07-29 Mehrad Soltani , Luis Rueda

Most existing methods handle cell instance segmentation problems directly without relying on additional detection boxes. These methods generally fails to separate touching cells due to the lack of global understanding of the objects. In…

Computer Vision and Pattern Recognition · Computer Science 2019-07-29 Jingru Yi , Pengxiang Wu , Qiaoying Huang , Hui Qu , Bo Liu , Daniel J. Hoeppner , Dimitris N. Metaxas

Retinal image segmentation plays an important role in automatic disease diagnosis. This task is very challenging because the complex structure and texture information are mixed in a retinal image, and distinguishing the information is…

Image and Video Processing · Electrical Eng. & Systems 2020-08-04 Shihao Zhang , Huazhu Fu , Yanwu Xu , Yanxia Liu , Mingkui Tan

We share our recent findings in an attempt to train a universal segmentation network for various cell types and imaging modalities. Our method was built on the generalized U-Net architecture, which allows the evaluation of each component…

Computer Vision and Pattern Recognition · Computer Science 2022-08-01 Tianqi Guo , Yin Wang , Luis Solorio , Jan P. Allebach

Pathological diagnosis is the gold standard for cancer diagnosis, but it is labor-intensive, in which tasks such as cell detection, classification, and counting are particularly prominent. A common solution for automating these tasks is…

Image and Video Processing · Electrical Eng. & Systems 2021-10-27 Anyu Mao , Jialun Wu , Xinrui Bao , Zeyu Gao , Tieliang Gong , Chen Li

The advent of single-cell technology has significantly improved our understanding of cellular states and subpopulations in various tissues under normal and diseased conditions by employing data-driven approaches such as clustering and…

When applying automatic analysis of fluorescence or histopathological images of cells, it is necessary to partition, or de-clump, partially overlapping cell nuclei. In this work, I describe a method of partitioning partially overlapping…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 James Kapaldo

We introduce a graphical method originating from the computer graphics domain that is used for the arbitrary and intuitive placement of cells over a two-dimensional manifold. Using a bitmap image as input, where the color indicates the…

Neural and Evolutionary Computing · Computer Science 2018-03-23 Nicolas P. Rougier

Two segmentation methods, one atlas-based and one neural-network-based, were compared to see how well they can each automatically segment the brain stem and cerebellum in Displacement Encoding with Stimulated Echoes Magnetic Resonance…

Image and Video Processing · Electrical Eng. & Systems 2021-09-30 Elle Buser , Emma Hart , Ben Huenemann

In medicine, visualizing chromosomes is important for medical diagnostics, drug development, and biomedical research. Unfortunately, chromosomes often overlap and it is necessary to identify and distinguish between the overlapping…

Computer Vision and Pattern Recognition · Computer Science 2017-12-21 R. Lily Hu , Jeremy Karnowski , Ross Fadely , Jean-Patrick Pommier

Skin lesion segmentation is one of the crucial steps for an efficient non-invasive computer-aided early diagnosis of melanoma. This paper investigates how color information, besides saliency, can be used to determine the pigmented lesion…

Image and Video Processing · Electrical Eng. & Systems 2021-11-08 Giuliana Ramella

This study presents a novel algorithm based on machine learning (ML) for the precise segmentation and measurement of detonation cells from soot foil images, addressing the limitations of manual and primitive edge detection methods prevalent…

Machine Learning · Computer Science 2024-09-12 Vansh Sharma , Michael Ullman , Venkat Raman

Automated detection and segmentation of pulmonary nodules on lung computed tomography (CT) scans can facilitate early lung cancer diagnosis. Existing supervised approaches for automated nodule segmentation on CT scans require voxel-based…

Computer Vision and Pattern Recognition · Computer Science 2018-02-26 Xinyang Feng , Jie Yang , Andrew F. Laine , Elsa D. Angelini

Accurate segmentation of critical anatomical structures is at the core of medical image analysis. The main bottleneck lies in gathering the requisite expert-labeled image annotations in a scalable manner. Methods that permit to produce…

Computer Vision and Pattern Recognition · Computer Science 2020-07-09 Yuhang Lu , Weijian Li , Kang Zheng , Yirui Wang , Adam P. Harrison , Chihung Lin , Song Wang , Jing Xiao , Le Lu , Chang-Fu Kuo , Shun Miao

Cells are the fundamental unit of biological organization, and identifying them in imaging data - cell segmentation - is a critical task for various cellular imaging experiments. While deep learning methods have led to substantial progress…

Melanoma is a life-threatening form of skin cancer when left undiagnosed at the early stages. Although there are more cases of non-melanoma cancer than melanoma cancer, melanoma cancer is more deadly. Early detection of melanoma is crucial…

Image and Video Processing · Electrical Eng. & Systems 2020-05-15 Shreshth Saini , Divij Gupta , Anil Kumar Tiwari

We propose a new deterministic methodology to predict RNA sequence and protein folding. Is stem enough for structure prediction? The main idea is to consider all possible stem formation in the given sequence. With the stem loop energy and…

Discrete Mathematics · Computer Science 2022-01-19 Mengyi Tang , Kumbit Hwang , Sung Ha Kang

Automatic segmentation of medical images is an important task for many clinical applications. In practice, a wide range of anatomical structures are visualised using different imaging modalities. In this paper, we investigate whether a…

Computer Vision and Pattern Recognition · Computer Science 2017-04-12 Pim Moeskops , Jelmer M. Wolterink , Bas H. M. van der Velden , Kenneth G. A. Gilhuijs , Tim Leiner , Max A. Viergever , Ivana Išgum