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This is a set of lecture notes for a graduate-level course on quantum algorithms, with an emphasis on quantum optimization algorithms. It is developed for applied mathematicians and engineers, and requires no previous background in quantum…

Quantum Physics · Physics 2025-07-09 Giacomo Nannicini

Clinical trials are pivotal in the drug discovery process to determine the safety and efficacy of a drug candidate. The high failure rates of these trials are attributed to deficiencies in clinical model development and protocol design.…

Hybrid quantum-classical algorithms hold great promise for solving quantum control problems on near-term quantum computers. In this work, we employ the hybrid framework that integrates digital quantum simulation with classical optimization…

Quantum Physics · Physics 2025-07-01 Tangyou Huang , Jing-Jun Zhu , Zhong-Yi Ni

The search for meaningful structure in biological data has relied on cutting-edge advances in computational technology and data science methods. However, challenges arise as we push the limits of scale and complexity in biological problems.…

Over the past decade, the usefulness of quantum annealing hardware for combinatorial optimization has been the subject of much debate. Thus far, experimental benchmarking studies have indicated that quantum annealing hardware does not…

Optimization and Control · Mathematics 2022-10-11 Byron Tasseff , Tameem Albash , Zachary Morrell , Marc Vuffray , Andrey Y. Lokhov , Sidhant Misra , Carleton Coffrin

We present a framework wherein the trajectory optimization problem (or a problem involving calculus of variations) is formulated as a search problem in a discrete space. A distinctive feature of our work is the treatment of discretization…

Optimization and Control · Mathematics 2022-12-22 Alok Shukla , Prakash Vedula

Scientists have demonstrated that quantum computing has presented novel approaches to address computational challenges, each varying in complexity. Adapting problem-solving strategies is crucial to harness the full potential of quantum…

Computational Complexity · Computer Science 2024-09-13 Arash Vaezi , Ali Movaghar , Mohammad Ghodsi , Seyed Mohammad Hussein Kazemi , Negin Bagheri Noghrehy , Seyed Mohsen Kazemi

In this paper, we introduce a quantum-enhanced algorithm for simulation-based optimization. Simulation-based optimization seeks to optimize an objective function that is computationally expensive to evaluate exactly, and thus, is…

Quantum Physics · Physics 2021-03-08 Julien Gacon , Christa Zoufal , Stefan Woerner

Quantum computers are expected to surpass the computational capabilities of classical computers during this decade and have transformative impact on numerous industry sectors, particularly finance. In fact, finance is estimated to be the…

Quantum Physics · Physics 2022-06-29 Dylan Herman , Cody Googin , Xiaoyuan Liu , Alexey Galda , Ilya Safro , Yue Sun , Marco Pistoia , Yuri Alexeev

The last five years have seen a dramatic evolution of platforms for quantum computing, taking the field from physics experiments to quantum hardware and software engineering. Nevertheless, despite this progress of quantum processors, the…

Quantum Physics · Physics 2023-02-10 G. Wendin

A broad class of hybrid quantum-classical algorithms known as "variational algorithms" have been proposed in the context of quantum simulation, machine learning, and combinatorial optimization as a means of potentially achieving a quantum…

Quantum Physics · Physics 2021-04-09 Aram Harrow , John Napp

To arrive at some viable product design, product development processes frequently use numerical simulations and mathematical programming techniques. Topology optimization, in particular, is one of the most promising techniques for…

Quantum Physics · Physics 2025-05-06 Yuki Sato , Ruho Kondo , Satoshi Koide , Seiji Kajita

The thesis deals with Quantum Algorithms for solving Hard Constrained Optimization Problems. It shows how quantum computers can solve difficult everyday problems such as finding the best schedule for social workers or the path of a robot…

Quantum Physics · Physics 2022-03-01 Parfait Atchade-Adelomou

Quantum computation and quantum information are of great current interest in computer science, mathematics, physical sciences and engineering. They will likely lead to a new wave of technological innovations in communication, computation…

Methodology · Statistics 2012-10-03 Yazhen Wang

Quantum computing is transitioning from laboratory research to industrial deployment, yet significant challenges persist: system scalability and performance, fabrication yields, and the advancement of algorithms and applications. We…

Fuelled by increasing computer power and algorithmic advances, machine learning techniques have become powerful tools for finding patterns in data. Since quantum systems produce counter-intuitive patterns believed not to be efficiently…

Quantum Physics · Physics 2018-05-14 Jacob Biamonte , Peter Wittek , Nicola Pancotti , Patrick Rebentrost , Nathan Wiebe , Seth Lloyd

A reinforcement algorithm solves a classical optimization problem by introducing a feedback to the system which slowly changes the energy landscape and converges the algorithm to an optimal solution in the configuration space. Here, we use…

Disordered Systems and Neural Networks · Physics 2017-11-08 A. Ramezanpour

We provide several quantum algorithms for continuous optimization that do not require gradient estimation. Instead, we encode the optimization problem into the dynamics of a physical system and coherently simulate the time evolution. We…

Quantum Physics · Physics 2026-03-18 Ahmet Burak Catli , Sophia Simon , Nathan Wiebe

Quantum Machine Learning represents a paradigm shift at the intersection of Quantum Computing and Machine Learning, leveraging quantum phenomena such as superposition, entanglement, and quantum parallelism to address the limitations of…

Quantum Physics · Physics 2025-01-17 Sahil Tomar , Rajeshwar Tripathi , Sandeep Kumar

Quantum computing improves substantially on known classical algorithms for various important problems, but the nature of the relationship between quantum and classical computing is not yet fully understood. This relationship can be…

Quantum Physics · Physics 2026-02-20 Jacques Carette , Chris Heunen , Robin Kaarsgaard , Neil J. Ross , Amr Sabry