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We introduce and study a mathematical framework for a broad class of regularization functionals for ill-posed inverse problems: Regularization Graphs. Regularization graphs allow to construct functionals using as building blocks linear…

Optimization and Control · Mathematics 2022-09-28 Kristian Bredies , Marcello Carioni , Martin Holler

The multivariate regression model basically offers the analysis of a single dataset with multiple responses. However, such a single-dataset analysis often leads to unsatisfactory results. Integrative analysis is an effective method to pool…

Methodology · Statistics 2023-04-18 Shuichi Kawano , Toshikazu Fukushima , Junichi Nakagawa , Mamoru Oshiki

As one of the most powerful tools for examining the association between functional covariates and a response, the functional regression model has been widely adopted in various interdisciplinary studies. Usually, a limited number of…

Methodology · Statistics 2025-01-07 Hanteng Ma , Ziliang Shen , Xingdong Feng , Xin Liu

Finite mixtures of regression models offer a flexible framework for investigating heterogeneity in data with functional dependencies. These models can be conveniently used for unsupervised learning on data with clear regression…

Methodology · Statistics 2013-12-03 Utkarsh J. Dang , Paul D. McNicholas

A novel functional additive model is proposed which is uniquely modified and constrained to model nonlinear interactions between a treatment indicator and a potentially large number of functional and/or scalar pretreatment covariates. The…

Methodology · Statistics 2021-01-26 Hyung Park , Eva Petkova , Thaddeus Tarpey , R. Todd Ogden

Physical activity is crucial for human health. With the increasing availability of large-scale mobile health data, strong associations have been found between physical activity and various diseases. However, accurately capturing this…

Applications · Statistics 2025-01-03 Xiaojing Sun , Bingxin Zhao , Fei Xue

Shape restrictions on functional regression coefficients such as non-negativity, monotonicity, convexity or concavity are often available in the form of a prior knowledge or required to maintain a structural consistency in functional…

Methodology · Statistics 2022-09-13 Rahul Ghosal , Sujit Ghosh , Jacek Urbanek , Jennifer A. Schrack , Vadim Zipunnikov

We develop a new method to fit the multivariate response linear regression model that exploits a parametric link between the regression coefficient matrix and the error covariance matrix. Specifically, we assume that the correlations…

Methodology · Statistics 2021-12-09 Aaron J. Molstad , Guangwei Weng , Charles R. Doss , Adam J. Rothman

This paper introduces a novel mixture model-based approach for simultaneous clustering and optimal segmentation of functional data which are curves presenting regime changes. The proposed model consists in a finite mixture of piecewise…

Methodology · Statistics 2014-05-02 Faicel Chamroukhi

In this paper, we propose the Graph-Fused Multivariate Regression (GFMR) via Total Variation regularization, a novel method for estimating the association between a one-dimensional or multidimensional array outcome and scalar predictors.…

Methodology · Statistics 2020-01-15 Ying Liu , Bowei Yan , Kathleen Merikangas , Haochang Shou

Modern biomedical studies frequently collect complex, high-dimensional physiological signals using wearables and sensors along with time-to-event outcomes, making efficient variable selection methods crucial for interpretation and improving…

Methodology · Statistics 2026-04-22 Yuanzhen Yue , Stella Self , Yichao Wu , Jiajia Zhang , Rahul Ghosal

In a multiple linear regression model, the algebraic formula of the decomposition theorem explains the relationship between the univariate regression coefficient and partial regression coefficient using geometry. It was found that…

Methodology · Statistics 2021-05-04 Xingguo Wu

We propose a Bayesian modeling framework for jointly analyzing multiple functional responses of different types (e.g. binary and continuous data). Our approach is based on a multivariate latent Gaussian process and models the dependence…

Methodology · Statistics 2016-01-12 Beth A. Tidemann-Miller , Brian J. Reich , Ana-Maria Staicu

This paper investigates a general regularization framework for unsupervised domain adaptation in vector-valued regression under the covariate shift assumption, utilizing vector-valued reproducing kernel Hilbert spaces (vRKHS). Covariate…

Statistics Theory · Mathematics 2026-01-30 Markus Holzleitner , Sergiy Pereverzyev , Sergei V. Pereverzyev , Vaibhav Silmana , S. Sivananthan

In many real-world applications, functional data exhibit considerable variability in both amplitude and phase. This is especially true in biomechanical data such as the knee flexion angle dataset motivating our work, where timing…

Methodology · Statistics 2025-06-18 Jacopo Gardella , Raffaele Argiento , Alessandro Casa , Alessia Pini

In genetical genomics studies, it is important to jointly analyze gene expression data and genetic variants in exploring their associations with complex traits, where the dimensionality of gene expressions and genetic variants can both be…

Methodology · Statistics 2014-04-15 Wei Lin , Rui Feng , Hongzhe Li

Graphs and networks are common ways of depicting biological information. In biology, many different biological processes are represented by graphs, such as regulatory networks, metabolic pathways and protein--protein interaction networks.…

Applications · Statistics 2010-11-16 Caiyan Li , Hongzhe Li

While extensive work has been done to correct for biases due to measurement error in scalar-valued covariates prone to errors in generalized linear regression models, limited work has been done to address biases associated with functional…

Methodology · Statistics 2023-05-16 Yuanyuan Luan , Roger S. Zoh , Sneha Jadhav , Lan Xue , Carmen D. Tekwe

Elastic Riemannian metrics have been used successfully in the past for statistical treatments of functional and curve shape data. However, this usage has suffered from an important restriction: the function boundaries are assumed fixed and…

Methodology · Statistics 2021-05-19 Darshan Bryner , Anuj Srivastava

We study a functional linear regression model that deals with functional responses and allows for both functional covariates and high-dimensional vector covariates. The proposed model is flexible and nests several functional regression…

Statistics Theory · Mathematics 2022-08-24 Daren Wang , Zifeng Zhao , Yi Yu , Rebecca Willett
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