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Deep generative models, such as generative adversarial networks (GANs), have been employed for $de~novo$ molecular generation in drug discovery. Most prior studies have utilized reinforcement learning (RL) algorithms, particularly Monte…

Biomolecules · Quantitative Biology 2025-09-09 Huidong Tang , Chen Li , Sayaka Kamei , Yoshihiro Yamanishi , Yasuhiko Morimoto

Dynamic dispatching is one of the core problems for operation optimization in traditional industries such as mining, as it is about how to smartly allocate the right resources to the right place at the right time. Conventionally, the…

Machine Learning · Computer Science 2020-08-26 Chi Zhang , Philip Odonkor , Shuai Zheng , Hamed Khorasgani , Susumu Serita , Chetan Gupta

This paper explores a deep reinforcement learning approach applied to the packet routing problem with high-dimensional constraints instigated by dynamic and autonomous communication networks. Our approach is motivated by the fact that…

Networking and Internet Architecture · Computer Science 2020-03-05 Ramy E. Ali , Bilgehan Erman , Ejder Baştuğ , Bruce Cilli

Differentiable quantum architecture search (DQAS) is a gradient-based framework to design quantum circuits automatically in the NISQ era. It was motivated by such as low fidelity of quantum hardware, low flexibility of circuit architecture,…

Quantum Physics · Physics 2023-09-21 Yize Sun , Yunpu Ma , Volker Tresp

Despite the notable success of deep neural networks (DNNs) in solving complex tasks, the training process still remains considerable challenges. A primary obstacle is the substantial time required for training, particularly as high…

Machine Learning · Computer Science 2025-09-09 Viet Hoang Pham , Hyo-Sung Ahn

Reinforcement learning algorithms are gaining popularity in fields in which optimal scheduling is important, and oncology is not an exception. The complex and uncertain dynamics of cancer limit the performance of traditional model-based…

Machine Learning · Computer Science 2019-09-04 Jesus Tordesillas , Juncal Arbelaiz

Most combinatorial optimization problems can be formulated as mixed integer linear programming (MILP), in which branch-and-bound (B\&B) is a general and widely used method. Recently, learning to branch has become a hot research topic in the…

Machine Learning · Computer Science 2022-01-19 Qingyu Qu , Xijun Li , Yunfan Zhou , Jia Zeng , Mingxuan Yuan , Jie Wang , Jinhu Lv , Kexin Liu , Kun Mao

There is increasing interest in data-driven approaches for recommending optimal treatment strategies in many chronic disease management and critical care applications. Reinforcement learning methods are well-suited to this sequential…

Machine Learning · Computer Science 2023-06-14 Milashini Nambiar , Supriyo Ghosh , Priscilla Ong , Yu En Chan , Yong Mong Bee , Pavitra Krishnaswamy

Optimizing techniques for discovering molecular structures with desired properties is crucial in artificial intelligence(AI)-based drug discovery. Combining deep generative models with reinforcement learning has emerged as an effective…

Machine Learning · Computer Science 2024-04-01 Jinyeong Park , Jaegyoon Ahn , Jonghwan Choi , Jibum Kim

Future generations of mobile networks are expected to contain more and more antennas with growing complexity and more parameters. Optimizing these parameters is necessary for ensuring the good performance of the network. The scale of mobile…

Networking and Internet Architecture · Computer Science 2023-02-03 Maxime Bouton , Jaeseong Jeong , Jose Outes , Adriano Mendo , Alexandros Nikou

The massive integration of renewable-based distributed energy resources (DERs) inherently increases the energy system's complexity, especially when it comes to defining its operational schedule. Deep reinforcement learning (DRL) algorithms…

Systems and Control · Electrical Eng. & Systems 2023-05-10 Hou Shengren , Pedro P. Vergara , Edgar Mauricio Salazar Duque , Peter Palensky

Reinforcement learning (RL) is a classical tool to solve network control or policy optimization problems in unknown environments. The original Q-learning suffers from performance and complexity challenges across very large networks. Herein,…

Machine Learning · Computer Science 2024-09-02 Talha Bozkus , Urbashi Mitra

A growing trend for value-based reinforcement learning (RL) algorithms is to capture more information than scalar value functions in the value network. One of the most well-known methods in this branch is distributional RL, which models…

Machine Learning · Computer Science 2021-10-27 Pushi Zhang , Xiaoyu Chen , Li Zhao , Wei Xiong , Tao Qin , Tie-Yan Liu

Molecular representation learning lays the foundation for drug discovery. However, existing methods suffer from poor out-of-distribution (OOD) generalization, particularly when data for training and testing originate from different…

Machine Learning · Computer Science 2023-10-24 Xiang Zhuang , Qiang Zhang , Keyan Ding , Yatao Bian , Xiao Wang , Jingsong Lv , Hongyang Chen , Huajun Chen

A wireless network operator typically divides the radio spectrum it possesses into a number of subbands. In a cellular network those subbands are then reused in many cells. To mitigate co-channel interference, a joint spectrum and power…

Signal Processing · Electrical Eng. & Systems 2020-12-22 Yasar Sinan Nasir , Dongning Guo

Diffusion in solids is a slow process that dictates rate-limiting processes in key chemical reactions. Unlike crystalline solids that offer well-defined diffusion pathways, the lack of similar structural motifs in amorphous or glassy…

Materials Science · Physics 2023-12-12 Ken-ichi Nomura , Ankit Mishra , Tian Sang , Rajiv K. Kalia , Aiichiro Nakano , Priya Vashishta

This paper proposes a differentiable robust LQR layer for reinforcement learning and imitation learning under model uncertainty and stochastic dynamics. The robust LQR layer can exploit the advantages of robust optimal control and…

Robotics · Computer Science 2021-06-11 Ngo Anh Vien , Gerhard Neumann

This thesis develops data-driven machine learning algorithms to managing and optimizing the next-generation highly complex cyberphysical systems, which desperately need ground-breaking control, monitoring, and decision making schemes that…

Machine Learning · Computer Science 2022-02-14 Alireza Sadeghi

We consider a dynamic multichannel access problem, where multiple correlated channels follow an unknown joint Markov model. A user at each time slot selects a channel to transmit data and receives a reward based on the success or failure of…

Networking and Internet Architecture · Computer Science 2018-02-21 Shangxing Wang , Hanpeng Liu , Pedro Henrique Gomes , Bhaskar Krishnamachari

In this paper, we propose a principled deep reinforcement learning (RL) approach that is able to accelerate the convergence rate of general deep neural networks (DNNs). With our approach, a deep RL agent (synonym for optimizer in this work)…

Machine Learning · Computer Science 2017-07-14 Jie Fu