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We explore the hyperparameters and introduce a methodological framework to convert disease patterns from time series data of blood test results into correlation graphs for causal hypothesis exploration. The networks represent hypotheses…

Other Quantitative Biology · Quantitative Biology 2025-12-29 David Patrick Duys Montealegre , Alexander Fulton , Mahta Haghighat Ghahfarokhi , Abicumaran Uthamacumaran , Hector Zenil

In the health domain, decisions are often based on different data modalities. Thus, when creating prediction models, multimodal fusion approaches that can extract and combine relevant features from different data modalities, can be highly…

Artificial Intelligence · Computer Science 2024-02-20 Mafalda Malafaia , Thalea Schlender , Peter A. N. Bosman , Tanja Alderliesten

In this paper, we construct two research objectives: i) explore the learned embedding space of BiomedCLIP, an open-source large vision language model, to analyse meaningful class separations, and ii) quantify the limitations of BiomedCLIP…

Computer Vision and Pattern Recognition · Computer Science 2025-06-18 Nafiz Sadman , Farhana Zulkernine , Benjamin Kwan

Inflammatory bowel diseases (IBD) are complex diseases in which the gut microbiota is attacked by the immune system of genetically predisposed subjects when they are exposed to yet unclear environmental factors. The complexity of this class…

Quantitative Methods · Quantitative Biology 2022-08-17 Mirko Hu , Guido Caldarelli , Tommaso Gili

Multimodal deep learning has shown strong potential in medical applications by integrating heterogeneous data sources such as medical images and structured clinical variables. However, most existing approaches implicitly assume complete…

Machine Learning · Computer Science 2026-05-13 Camillo Maria Caruso , Valerio Guarrasi , Paolo Soda

The dissection of hyperspectral images into intrinsic components through hyperspectral intrinsic image decomposition (HIID) enhances the interpretability of hyperspectral data, providing a foundation for more accurate classification…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Zhiqiang Gong , Xian Zhou , Wen Yao , Xiaohu Zheng , Ping Zhong

Online deep learning tackles the challenge of learning from data streams by balancing two competing goals: fast learning and deep learning. However, existing research primarily emphasizes deep learning solutions, which are more adept at…

Machine Learning · Computer Science 2025-03-24 Antonios Valkanas , Boris N. Oreshkin , Mark Coates

Objective: The proper handling of missing values is critical to delivering reliable estimates and decisions, especially in high-stakes fields such as clinical research. The increasing diversity and complexity of data have led many…

The rapid advancement of high-throughput sequencing and other assay technologies has resulted in the generation of large and complex multi-omics datasets, offering unprecedented opportunities for advancing precision medicine strategies.…

Quantitative Methods · Quantitative Biology 2025-01-30 Ana R. Baião , Zhaoxiang Cai , Rebecca C Poulos , Phillip J. Robinson , Roger R Reddel , Qing Zhong , Susana Vinga , Emanuel Gonçalves

Motivation: Drug discovery demands rapid quantification of compound-protein interaction (CPI). However, there is a lack of methods that can predict compound-protein affinity from sequences alone with high applicability, accuracy, and…

Biomolecules · Quantitative Biology 2020-12-17 Mostafa Karimi , Di Wu , Zhangyang Wang , Yang Shen

Epidemiologic and genetic studies in chronic obstructive pulmonary disease (COPD) and many complex diseases suggest subgroup disparities (e.g., by sex). We consider this problem from the standpoint of integrative analysis where we combine…

Methodology · Statistics 2023-09-26 J. Butts , C. Wendt , R. Bowler , C. P. Hersh , Q. Long , L. Eberly , S. E. Safo

In this paper, we develop a graphical modeling framework for the inference of networks across multiple sample groups and data types. In medical studies, this setting arises whenever a set of subjects, which may be heterogeneous due to…

In the real world, medical datasets often exhibit a long-tailed data distribution (i.e., a few classes occupy the majority of the data, while most classes have only a limited number of samples), which results in a challenging long-tailed…

Computer Vision and Pattern Recognition · Computer Science 2023-03-22 Lie Ju , Zhen Yu , Lin Wang , Xin Zhao , Xin Wang , Paul Bonnington , Zongyuan Ge

Managing fluid balance in dialysis patients is crucial, as improper management can lead to severe complications. In this paper, we propose a multimodal approach that integrates visual features from lung ultrasound images with clinical data…

Image and Video Processing · Electrical Eng. & Systems 2024-10-04 Tianqi Yang , Nantheera Anantrasirichai , Oktay Karakuş , Marco Allinovi , Alin Achim

Fine-grained glomerular subtyping is central to kidney biopsy interpretation, but clinically valuable labels are scarce and difficult to obtain. Existing computational pathology approaches instead tend to evaluate coarse diseased…

To improve decision-making and planning efficiency in back-end centralized redundant supply chains, this paper proposes a decision model integrating deep learning with intelligent particle swarm optimization. A distributed node deployment…

Machine Learning · Computer Science 2025-11-04 Shiman Zhang , Jinghan Zhou , Zhoufan Yu , Ningai Leng

Acute Lymphoblastic Leukemia (ALL) is one of the most common types of childhood blood cancer. The quick start of the treatment process is critical to saving the patient's life, and for this reason, early diagnosis of this disease is…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Amirhossein Askari Farsangi , Ali Sharifi-Zarchi , Mohammad Hossein Rohban

Clustering is commonly performed as an initial analysis step for uncovering structure in 'omics datasets, e.g. to discover molecular subtypes of disease. The high-throughput, high-dimensional nature of these datasets means that they provide…

Methodology · Statistics 2023-03-02 Paul D. W. Kirk , Filippo Pagani , Sylvia Richardson

We establish a broad methodological foundation for mixed-integer optimization with learned constraints. We propose an end-to-end pipeline for data-driven decision making in which constraints and objectives are directly learned from data…

Optimization and Control · Mathematics 2023-10-30 Donato Maragno , Holly Wiberg , Dimitris Bertsimas , S. Ilker Birbil , Dick den Hertog , Adejuyigbe Fajemisin

Deep learning has been widely used for medical image segmentation and a large number of papers has been presented recording the success of deep learning in the field. In this paper, we present a comprehensive thematic survey on medical…

Image and Video Processing · Electrical Eng. & Systems 2022-01-19 Risheng Wang , Tao Lei , Ruixia Cui , Bingtao Zhang , Hongying Meng , Asoke K. Nandi