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Dynamical systems are frequently used to model biological systems. When these models are fit to data it is necessary to ascertain the uncertainty in the model fit. Here we present prediction deviation, a new metric of uncertainty that…

Applications · Statistics 2017-06-08 Benjamin Letham , Portia A. Letham , Cynthia Rudin , Edward P. Browne

We consider a patient risk models which has access to patient features such as vital signs, lab values, and prior history but does not have access to a patient's diagnosis. For example, this occurs in a model deployed at intake time for…

Artificial Intelligence · Computer Science 2023-07-03 Alexander Peysakhovich , Rich Caruana , Yin Aphinyanaphongs

Individuals use models to guide decisions, but many models are wrong. This paper studies which misspecified models are likely to persist when individuals also entertain alternative models. Consider an agent who uses her model to learn the…

Theoretical Economics · Economics 2023-08-22 Cuimin Ba

Counterfactual prediction methods are required when a model will be deployed in a setting where treatment policies differ from the setting where the model was developed, or when a model provides predictions under hypothetical interventions…

Methodology · Statistics 2025-08-13 Christopher B. Boyer , Issa J. Dahabreh , Jon A. Steingrimsson

LLMs are increasingly used to make or support high-stakes decisions under uncertainty, where alignment depends not only on factual accuracy but on how models weigh tradeoffs between different outcomes. We present an empirical pipeline for…

Machine Learning · Computer Science 2026-05-12 Khurram Yamin , Jingjing Tang , Eric Horvitz , Bryan Wilder

Precision psychiatry is an ermerging field that aims to provide individualized approaches to mental health care. Multivariate analysis and machine learning are used to create outcome prediction models based on clinical data such as…

Quantitative Methods · Quantitative Biology 2024-05-29 Edwin van Dellen

Machine learning can be used to make sense of healthcare data. Probabilistic machine learning models help provide a complete picture of observed data in healthcare. In this review, we examine how probabilistic machine learning can advance…

Machine Learning · Statistics 2020-09-24 Irene Y. Chen , Shalmali Joshi , Marzyeh Ghassemi , Rajesh Ranganath

Mathematical models are used extensively for diverse tasks including analysis, optimization, and decision making. Frequently, those models are principled but imperfect representations of reality. This is either due to incomplete physical…

Machine Learning · Statistics 2017-11-15 Remi R. Lam , Lior Horesh , Haim Avron , Karen E. Willcox

We emphasize the importance of asking the right question when interpreting the decisions of a learning model. We discuss a natural extension of the theoretical machinery from Janzing et. al. 2020, which answers the question "Why did my…

Machine Learning · Statistics 2020-12-11 Debraj Basu

In many practical applications of AI, an AI model is used as a decision aid for human users. The AI provides advice that a human (sometimes) incorporates into their decision-making process. The AI advice is often presented with some measure…

Artificial Intelligence · Computer Science 2022-10-31 Kailas Vodrahalli , Tobias Gerstenberg , James Zou

When solving optimization problems under uncertainty with contextual data, utilizing machine learning to predict the uncertain parameters' values is a popular and effective approach. Decision-focused learning (DFL) aims at learning a…

Machine Learning · Computer Science 2026-01-29 Noah Schutte , Grigorii Veviurko , Krzysztof Postek , Neil Yorke-Smith

Allocational harms occur when resources or opportunities are unfairly withheld from specific groups. Many proposed bias measures ignore the discrepancy between predictions, which are what the proposed methods consider, and decisions that…

Computation and Language · Computer Science 2026-03-09 Hannah Cyberey , Yangfeng Ji , David Evans

Selective classification allows models to abstain from making predictions (e.g., say "I don't know") when in doubt in order to obtain better effective accuracy. While typical selective models can be effective at producing more accurate…

Machine Learning · Computer Science 2024-06-24 Adam Fisch , Tommi Jaakkola , Regina Barzilay

Machine learning models only provide probabilistic guarantees on the expected loss of random samples from the distribution represented by their training data. As a result, a model with high accuracy, may or may not be reliable for…

Databases · Computer Science 2024-04-12 Nima Shahbazi , Abolfazl Asudeh

Binary classification models which can assign probabilities to categories such as "the tissue is 75% likely to be tumorous" or "the chemical is 25% likely to be toxic" are well understood statistically, but their utility as an input to…

Applications · Statistics 2017-12-05 Damjan Krstajic , Ljubomir Buturovic , Simon Thomas , David E Leahy

AI has the potential to augment human decision making. However, even high-performing models can produce inaccurate predictions when deployed. These inaccuracies, combined with automation bias, where humans overrely on AI predictions, can…

Human-Computer Interaction · Computer Science 2025-08-12 Sarah Jabbour , David Fouhey , Nikola Banovic , Stephanie D. Shepard , Ella Kazerooni , Michael W. Sjoding , Jenna Wiens

Deep learning has the potential to automate many clinically useful tasks in medical imaging. However translation of deep learning into clinical practice has been hindered by issues such as lack of the transparency and interpretability in…

Image and Video Processing · Electrical Eng. & Systems 2022-05-04 Charles Lu , Andreanne Lemay , Ken Chang , Katharina Hoebel , Jayashree Kalpathy-Cramer

Predictive models are being increasingly used to support consequential decision making at the individual level in contexts such as pretrial bail and loan approval. As a result, there is increasing social and legal pressure to provide…

Machine Learning · Computer Science 2020-03-02 Amir-Hossein Karimi , Gilles Barthe , Borja Balle , Isabel Valera

Prediction models need reliable predictive performance as they inform clinical decisions, aiding in diagnosis, prognosis, and treatment planning. The predictive performance of these models is typically assessed through discrimination and…

Methodology · Statistics 2025-04-25 Wouter A. C. van Amsterdam

Bayesian models quantify uncertainty and facilitate optimal decision-making in downstream applications. For most models, however, practitioners are forced to use approximate inference techniques that lead to sub-optimal decisions due to…

Machine Learning · Statistics 2019-09-12 Tomasz Kuśmierczyk , Joseph Sakaya , Arto Klami