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The scientific process is a means to turn the results of experiments into knowledge about the world in which we live. Much research effort has been directed toward automating this process. To do this, one needs to formulate the scientific…

Machine Learning · Statistics 2025-10-14 Brendan van Rooyen

Consider the day when an invariant mass peak, roughly compatible with "the Higgs", begins to emerge, say at the LHC, ... and may you see that day. There will be a difference between discovery and scrutiny. The latter would involve an effort…

High Energy Physics - Phenomenology · Physics 2022-03-02 A. De Rujula

We consider the issue of reporting the result of search experiment in the most unbiased and efficient way, i.e. in a way which allows an easy interpretation and combination of results and which do not depend on whether the experimenters…

High Energy Physics - Experiment · Physics 2007-05-23 P. Astone , G. D'Agostini

Most major discoveries in astronomy are unplanned, and result from surveying the Universe in a new way, rather than by testing a hypothesis or conducting an investigation with planned outcomes. For example, of the 10 greatest discoveries…

Instrumentation and Methods for Astrophysics · Physics 2017-02-08 Ray P Norris

In this essay, I argue that modern science is not the dichotomous pairing of theory and experiment that it is typically presented as, and I offer an alternative paradigm defined by its functions as a human endeavor. I also demonstrate how…

History and Philosophy of Physics · Physics 2018-05-24 Ian T. Durham

Cosmology has come a long way from being based on a small number of observations to being a data-driven precision science. We discuss the questions "What is observable?", "What in the Universe is knowable?" and "What are the fundamental…

Cosmology and Nongalactic Astrophysics · Physics 2016-07-28 Florent Leclercq , Alice Pisani , Benjamin D. Wandelt

The crisis in the reproducibility of experiments invites a re-evaluation of methods of inquiry and validation procedures. The text challenges current assumptions of knowledge acquisition and introduces G-complexity for defining decidable…

Other Quantitative Biology · Quantitative Biology 2016-12-09 Mihai Nadin

Scientific discovery is mediated by ideas that, after being formulated in hypotheses, can be tested, validated, and quantified before they eventually lead to accepted concepts. Computer-mediated discovery in astrophysics is no exception,…

Instrumentation and Methods for Astrophysics · Physics 2018-09-17 Simon Portegies Zwart

The rapid evolution of artificial intelligence has led to expectations of transformative impact on science, yet current systems remain fundamentally limited in enabling genuine scientific discovery. This perspective contends that progress…

Artificial Intelligence · Computer Science 2025-12-16 Karthik Duraisamy

A qualitatively new, much more liberal and efficient organisation of science is proposed and justified, in connection with growing debate about further role and development of fundamental science. Although the key ideas can be explained…

General Physics · Physics 2007-05-23 Andrei P. Kirilyuk

Astrobiology is usually defined as the study of the origin, evolution, distribution, and future of life in the universe. As such it is inherently interdisciplinary and cannot help but engender a worldview infused by cosmic and evolutionary…

Popular Physics · Physics 2017-12-27 Ian A. Crawford

There has been significant recent progress in observational cosmology. This, in turn, has provided an unprecedented picture of the early universe and its evolution. In this review I will present a (biased) view of how one can use these…

Cosmology and Nongalactic Astrophysics · Physics 2015-06-16 Raul Jimenez

The scientific method is the cornerstone of human progress across all branches of the natural and applied sciences, from understanding the human body to explaining how the universe works. The scientific method is based on identifying…

Artificial Intelligence · Computer Science 2025-02-28 Gianmarco Mengaldo

In almost every scientific field, an experiment involves collecting data and then analysing it. The analysis stage will often consist in trying to extract some physical parameter and estimating its uncertainty; this is known as Parameter…

Data Analysis, Statistics and Probability · Physics 2015-06-12 Louis Lyons

Theory testing in the physical sciences has been revolutionized in recent decades by Bayesian approaches to probability theory. Here, I will consider Bayesian approaches to theory extensions, that is, theories like inflation which aim to…

Cosmology and Nongalactic Astrophysics · Physics 2017-04-07 Luke A. Barnes

The plausibility of uncommon events and miracles based on testimony of such an event has been much discussed. When analyzing the probabilities involved, it has mostly been assumed that the common events can be taken as data in the…

Applications · Statistics 2016-03-01 V. Palonen

A central challenge in statistical inference is the presence of confounding variables that may distort observed associations between treatment and outcome. Conventional "causal" methods, grounded in assumptions such as ignorability, exclude…

Methodology · Statistics 2025-09-09 Ellis Scharfenaker , Duncan K. Foley

The process of diagnosis involves learning about the state of a system from various observations of symptoms or findings about the system. Sophisticated Bayesian (and other) algorithms have been developed to revise and maintain beliefs…

Artificial Intelligence · Computer Science 2013-02-01 Mark Alan Peot , Ross D. Shachter

Bayesian inference gets its name from *Bayes's theorem*, expressing posterior probabilities for hypotheses about a data generating process as the (normalized) product of prior probabilities and a likelihood function. But Bayesian inference…

Methodology · Statistics 2024-07-02 Thomas J. Loredo , Robert L. Wolpert

The selection process of proposals is a crucial component of scientific progress and innovations. Limited resources must be allocated in the most effective way to maximise advancements and the production of new knowledge, especially as it…

Physics and Society · Physics 2015-04-22 Antonio Navarra