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In order to continuously represent molecules, we propose a generative model in the form of a VAE which is operating on the 2D-graph structure of molecules. A side predictor is employed to prune the latent space and help the decoder in…

Machine Learning · Computer Science 2020-04-20 Mohammadamin Tavakoli , Pierre Baldi

As deep learning is showing unprecedented success in medical image analysis tasks, the lack of sufficient medical data is emerging as a critical problem. While recent attempts to solve the limited data problem using Generative Adversarial…

Image and Video Processing · Electrical Eng. & Systems 2019-08-08 Gihyun Kwon , Chihye Han , Dae-shik Kim

We investigate methods of microstructure representation for the purpose of predicting processing condition from microstructure image data. A binary alloy (uranium-molybdenum) that is currently under development as a nuclear fuel was studied…

The vast amount of sequencing data presently available allow the scientific community to explore a range of genetic variables that may drive and progress cancer. A myriad of predictive tools has been proposed, allowing researchers and…

Genomics · Quantitative Biology 2023-03-31 Mona Nourbakhsh , Kristine Degn , Astrid Saksager , Matteo Tiberti , Elena Papaleo

An autoencoder (AE) is a neural network that, using self-supervised training, learns a succinct parameterized representation, and a corresponding encoding and decoding process, for all instances in a given class. Here, we introduce the…

Machine Learning · Computer Science 2025-07-15 Assaf Marron , Smadar Szekely , Irun Cohen , David Harel

The growth of global consumption has motivated important applications of deep learning to smart manufacturing and machine health monitoring. In particular, analyzing vibration data offers great potential to extract meaningful insights into…

Machine Learning · Computer Science 2024-05-30 Anthony Zhou , Amir Barati Farimani

Cancer is a term that denotes a group of diseases caused by abnormal growth of cells that can spread in different parts of the body. According to the World Health Organization (WHO), cancer is the second major cause of death after…

Machine Learning · Computer Science 2023-01-31 Fadi Alharbi , Aleksandar Vakanski

Accurate prediction of RNA properties, such as stability and interactions, is crucial for advancing our understanding of biological processes and developing RNA-based therapeutics. RNA structures can be represented as 1D sequences, 2D…

Quantitative Methods · Quantitative Biology 2025-04-22 Junjie Xu , Artem Moskalev , Tommaso Mansi , Mangal Prakash , Rui Liao

We propose a novel molecular fingerprint-based variational autoencoder applied for molecular generation on real-world drug molecules. We define more suitable and pharma-relevant baseline metrics and tests, focusing on the generation of…

Machine Learning · Computer Science 2022-11-17 Ruslan N. Tazhigulov , Joshua Schiller , Jacob Oppenheim , Max Winston

Identifying molecules that exhibit some pre-specified properties is a difficult problem to solve. In the last few years, deep generative models have been used for molecule generation. Deep Graph Variational Autoencoders are among the most…

Machine Learning · Computer Science 2023-06-09 Davide Rigoni , Nicolò Navarin , Alessandro Sperduti

Microstructure is key to controlling and understanding the properties of metallic materials, but traditional approaches to describing microstructure capture only a small number of features. To enable data-centric approaches to materials…

Medical coding is essential for standardizing clinical data and communication but is often time-consuming and prone to errors. Traditional Natural Language Processing (NLP) methods struggle with automating coding due to the large label…

The techniques of data-driven backmapping from coarse-grained (CG) to fine-grained (FG) representation often struggle with accuracy, unstable training, and physical realism, especially when applied to complex systems such as proteins. In…

Machine Learning · Computer Science 2025-05-26 Georgios Kementzidis , Erin Wong , John Nicholson , Ruichen Xu , Yuefan Deng

The paper proposes to employ deep convolutional neural networks (CNNs) to classify noncoding RNA (ncRNA) sequences. To this end, we first propose an efficient approach to convert the RNA sequences into images characterizing their…

Computer Vision and Pattern Recognition · Computer Science 2020-08-25 Brian McClannahan , Krushi Patel , Usman Sajid , Cuncong Zhong , Guanghui Wang

Masked language modelling (MLM) as a pretraining objective has been widely adopted in genomic sequence modelling. While pretrained models can successfully serve as encoders for various downstream tasks, the distribution shift between…

Machine Learning · Computer Science 2025-02-26 Monireh Safari , Pablo Millan Arias , Scott C. Lowe , Lila Kari , Angel X. Chang , Graham W. Taylor

Novel multimodal imaging methods are capable of generating extensive, super high resolution datasets for preclinical research. Yet, a massive lack of annotations prevents the broad use of deep learning to analyze such data. So far, existing…

Image and Video Processing · Electrical Eng. & Systems 2021-04-26 Izabela Horvath , Johannes C. Paetzold , Oliver Schoppe , Rami Al-Maskari , Ivan Ezhov , Suprosanna Shit , Hongwei Li , Ali Ertuerk , Bjoern H. Menze

Differential medical VQA models compare multiple images to identify clinically meaningful changes and rely on vision encoders to capture fine-grained visual differences that reflect radiologists' comparative diagnostic workflows. However,…

Computer Vision and Pattern Recognition · Computer Science 2026-04-23 Denis Musinguzi , Caren Han , Prasenjit Mitra

This methods paper presents computational protocols for the identification of non-coding RNA genes or RNA motifs within genomic sequences. An application to bacterial small RNA is proposed.

Quantitative Methods · Quantitative Biology 2015-12-23 Daniel Gautheret

Self-explaining text categorization requires a classifier to make a prediction along with supporting evidence. A popular type of evidence is sub-sequences extracted from the input text which are sufficient for the classifier to make the…

Computation and Language · Computer Science 2019-07-22 Zhiguo Wang , Yue Zhang , Mo Yu , Wei Zhang , Lin Pan , Linfeng Song , Kun Xu , Yousef El-Kurdi

Variational autoencoders (VAEs) and generative adversarial networks (GANs) enjoy an intuitive connection to manifold learning: in training the decoder/generator is optimized to approximate a homeomorphism between the data distribution and…

Machine Learning · Computer Science 2020-08-28 Henry Li , Ofir Lindenbaum , Xiuyuan Cheng , Alexander Cloninger
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