Related papers: Space--time Isogeometric Analysis of cardiac elect…
We present a novel approach which aims at high-performance uncertainty quantification for cardiac electrophysiology simulations. Employing the monodomain equation to model the transmembrane potential inside the cardiac cells, we evaluate…
In this paper, we consider the monodomain model of cardiac electrophysiology. After an analysis of the well-posedness of the forward problem, we show that perfectly insulating regions (modeling ischemic regions in the cardiac tissue) can be…
We present a novel approach aimed at high-performance uncertainty quantification for time-dependent problems governed by partial differential equations. In particular, we consider input uncertainties described by a Karhunen-Loeeve expansion…
In this paper we consider the monodomain model of cardiac electrophysiology. After an analysis of the well-posedness of the model, we determine an asymptotic expansion of the perturbed potential due to the presence of small conductivity…
This thesis aims at investigating the first steps toward an unconditionally stable space-time isogeometric method, based on splines of maximal regularity, for the linear acoustic wave equation. The unconditional stability of space-time…
For plane-wave and many-spiral states of the experimentally based Luo-Rudy 1 model of heart tissue in large (8 cm square) domains, we show that an explicit space-time-adaptive time-integration algorithm can achieve an order of magnitude…
We consider the monodomain model, a system of a parabolic semilinear reaction-diffusion equation coupled with a nonlinear ordinary differential equation, arising from the (simplified) mathematical description of the electrical activity of…
We present a novel space-time isogeometric discretization of the acoustic wave equation in second-order formulation that is intrinsically unconditionally stable. The method relies on a variational framework inspired by [Walkington 2014],…
The monodomain model is widely used in in-silico cardiology to describe excitation propagation in the myocardium. Frequently, operator splitting is used to decouple the stiff reaction term and the diffusion term in the monodomain model so…
We present a new explicit local space-time adaptive framework to decrease the time required for monodomain simulations for cardiac electrophysiology. Based on the localized structure of the steep activation wavefront in solutions to…
We present the meshfree Mixed Collocation Method (MCM) to solve the monodomain model for numerical simulation of cardiac electrophysiology. We apply MCM to simulate cardiac electrical propagation in 2D tissue sheets and 3D tissue slabs as…
We propose an innovative isogeometric space-time method for the heat equation, with smooth splines approximation in both space and time. To enhance the stability of the method we add a stabilizing term, based on a linear combination of…
The electrocardiogram (ECG) is a well-known technique used to diagnose cardiac diseases. To acquire the spatial signal characteristics from the thorax, multiple electrodes are commonly used. Displacements of electrodes affect the signal…
This work aims at presenting a Discontinuous Galerkin (DG) formulation employing a spectral basis for two important models employed in cardiac electrophysiology, namely the monodomain and bidomain models. The use of DG methods is motivated…
Fully explicit stabilized multirate (mRKC) methods are well-suited for the numerical solution of large multiscale systems of stiff ordinary differential equations thanks to their improved stability properties. To demonstrate their…
This work presents a space-time isogeometric analysis of biharmonic wave problem, in contrast to the more common application of space-time methods to second order wave equations. We first establish the unique solvability of the continuous…
This work deals with the numerical solution of the monodomain and bidomain models of electrical activity of myocardial tissue. The bidomain model is a system consisting of a possibly degenerate parabolic PDE coupled with an elliptic PDE for…
Objective: The bidomain model and the finite element method are an established standard to mathematically describe cardiac electrophysiology, but are both suboptimal choices for fast and large-scale simulations due to high computational…
Elastic wave propagation is studied in a heterogeneous 2-D medium consisting of an elastic matrix containing randomly distributed circular elastic inclusions. The aim of this study is to determine the effective wavenumbers when the incident…
A reduced-order model based on Proper Orthogonal Decomposition (POD) is proposed for the bidomain equations of cardiac electrophysiology. Its accuracy is assessed through electrocardiograms in various configurations, including myocardium…