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Although deep learning approaches have had tremendous success in image, video and audio processing, computer vision, and speech recognition, their applications to three-dimensional (3D) biomolecular structural data sets have been hindered…

Quantitative Methods · Quantitative Biology 2017-11-01 Zixuan Cang , Guo-Wei Wei

The segmentation of medical images is important for the improvement and creation of healthcare systems, particularly for early disease detection and treatment planning. In recent years, the use of convolutional neural networks (CNNs) and…

Image and Video Processing · Electrical Eng. & Systems 2024-01-12 Siddharth Tiwari

Recent advances in molecular representation learning have produced highly effective encodings of molecules for numerous cheminformatics and bioinformatics tasks. However, extracting general chemical insight while balancing predictive…

Machine Learning · Computer Science 2025-09-26 Rahul Khorana

Object segmentation and structure localization are important steps in automated image analysis pipelines for microscopy images. We present a convolution neural network (CNN) based deep learning architecture for segmentation of objects in…

Computer Vision and Pattern Recognition · Computer Science 2019-01-24 Shan E Ahmed Raza , Linda Cheung , Muhammad Shaban , Simon Graham , David Epstein , Stella Pelengaris , Michael Khan , Nasir M. Rajpoot

Persistent homology (PH) is a method for generating topology-inspired representations of data. Empirical studies that investigate the properties of PH, such as its sensitivity to perturbations or ability to detect a feature of interest,…

Algebraic Topology · Mathematics 2024-03-05 Shuang Liang , Renata Turkeš , Jiayi Li , Nina Otter , Guido Montúfar

The hybrid architecture of convolutional neural networks (CNNs) and Transformer are very popular for medical image segmentation. However, it suffers from two challenges. First, although a CNNs branch can capture the local image features…

Image and Video Processing · Electrical Eng. & Systems 2023-12-21 Tao Lei , Rui Sun , Xuan Wang , Yingbo Wang , Xi He , Asoke Nandi

Deep Convolutional Neural Networks (CNNs) for image classification successively alternate convolutions and downsampling operations, such as pooling layers or strided convolutions, resulting in lower resolution features the deeper the…

Computer Vision and Pattern Recognition · Computer Science 2022-09-29 Ioannis Vezakis , Antonios Vezakis , Sofia Gourtsoyianni , Vassilis Koutoulidis , George K. Matsopoulos , Dimitrios Koutsouris

Graph-based neural network models are gaining traction in the field of representation learning due to their ability to uncover latent topological relationships between entities that are otherwise challenging to identify. These models have…

Image and Video Processing · Electrical Eng. & Systems 2023-07-25 Aryan Singh , Pepijn Van de Ven , Ciarán Eising , Patrick Denny

[18F]-Fluorodeoxyglucose (FDG) positron emission tomography - computed tomography (PET-CT) has become the imaging modality of choice for diagnosing many cancers. Co-learning complementary PET-CT imaging features is a fundamental requirement…

Image and Video Processing · Electrical Eng. & Systems 2023-08-08 Lei Bi , Michael Fulham , Shaoli Song , David Dagan Feng , Jinman Kim

Segmenting curvilinear structures in medical images is essential for analyzing morphological patterns in clinical applications. Integrating topological properties, such as connectivity, improves segmentation accuracy and consistency.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Zhuangzhi Gao , Feixiang Zhou , He Zhao , Xiuju Chen , Xiaoxin Li , Qinkai Yu , Yitian Zhao , Alena Shantsila , Gregory Y. H. Lip , Eduard Shantsila , Yalin Zheng

Persistent homology is a mathematical tool used for studying the shape of data by extracting its topological features. It has gained popularity in network science due to its applicability in various network mining problems, including…

Algebraic Topology · Mathematics 2023-06-21 Mehmet Emin Aktas , Thu Nguyen , Rakin Riza , Muhammad Ifte Islam , Esra Akbas

Convolutional neural network (CNN) based methods have achieved great successes in medical image segmentation, but their capability to learn global representations is still limited due to using small effective receptive fields of convolution…

Computer Vision and Pattern Recognition · Computer Science 2022-11-17 Pengfei Gu , Yejia Zhang , Chaoli Wang , Danny Z. Chen

Automated medical image segmentation is becoming increasingly crucial to modern clinical practice, driven by the growing demand for precise diagnosis, the push towards personalized treatment plans, and the advancements in machine learning…

Image and Video Processing · Electrical Eng. & Systems 2023-11-13 Tan-Hanh Pham , Xianqi Li , Kim-Doang Nguyen

The convolutional neural network-based methods have become more and more popular for medical image segmentation due to their outstanding performance. However, they struggle with capturing long-range dependencies, which are essential for…

Image and Video Processing · Electrical Eng. & Systems 2024-01-30 Hongkun Sun , Jing Xu , Yuping Duan

Deep neural networks have been widely used in medical image analysis and medical image segmentation is one of the most important tasks. U-shaped neural networks with encoder-decoder are prevailing and have succeeded greatly in various…

Image and Video Processing · Electrical Eng. & Systems 2023-06-09 Juntao Jiang , Xiyu Chen , Guanzhong Tian , Yong Liu

The training of neural networks is usually monitored with a validation (holdout) set to estimate the generalization of the model. This is done instead of measuring intrinsic properties of the model to determine whether it is learning…

Machine Learning · Computer Science 2021-06-02 Asier Gutiérrez-Fandiño , David Pérez-Fernández , Jordi Armengol-Estapé , Marta Villegas

Topological structures in image data, such as connected components and loops, play a crucial role in understanding image content (e.g., biomedical objects). % Despite remarkable successes of numerous image processing methods that rely on…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Pengfei Gu , Hongxiao Wang , Yejia Zhang , Huimin Li , Chaoli Wang , Danny Chen

Persistent homology (PH) is one of the most popular methods in Topological Data Analysis. Even though PH has been used in many different types of applications, the reasons behind its success remain elusive; in particular, it is not known…

Algebraic Topology · Mathematics 2023-01-18 Renata Turkeš , Guido Montúfar , Nina Otter

Convolutional Neural Networks (CNNs) have been successful in solving tasks in computer vision including medical image segmentation due to their ability to automatically extract features from unstructured data. However, CNNs are sensitive to…

Image and Video Processing · Electrical Eng. & Systems 2022-03-18 Minh Tran , Viet-Khoa Vo-Ho , Kyle Quinn , Hien Nguyen , Khoa Luu , Ngan Le

For Convolutional Neural Network-based object detection, there is a typical dilemma: the spatial information is well kept in the shallow layers which unfortunately do not have enough semantic information, while the deep layers have a high…

Computer Vision and Pattern Recognition · Computer Science 2020-05-08 Ziming Liu , Guangyu Gao , Lin Sun , Li Fang