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High annotation costs are a substantial bottleneck in applying modern deep learning architectures to clinically relevant medical use cases, substantiating the need for novel algorithms to learn from unlabeled data. In this work, we propose…

Computer Vision and Pattern Recognition · Computer Science 2021-11-29 Aiham Taleb , Matthias Kirchler , Remo Monti , Christoph Lippert

Magnetic Resonance Imaging (MRI) typically recruits multiple sequences (defined here as "modalities"). As each modality is designed to offer different anatomical and functional clinical information, there are evident disparities in the…

Image and Video Processing · Electrical Eng. & Systems 2022-03-09 Chengjia Wang , Guang Yang , Giorgos Papanastasiou

Multi-modal MRIs are widely used in neuroimaging applications since different MR sequences provide complementary information about brain structures. Recent works have suggested that multi-modal deep learning analysis can benefit from…

Computer Vision and Pattern Recognition · Computer Science 2021-06-14 Jiahong Ouyang , Ehsan Adeli , Kilian M. Pohl , Qingyu Zhao , Greg Zaharchuk

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

Establishing voxelwise semantic correspondence across distinct imaging modalities is a foundational yet formidable computer vision task. Current multi-modality registration techniques maximize hand-crafted inter-domain similarity functions,…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Neel Dey , Jo Schlemper , Seyed Sadegh Mohseni Salehi , Bo Zhou , Guido Gerig , Michal Sofka

Magnetic resonance imaging (MRI) is crucial for enhancing diagnostic accuracy in clinical settings. However, the inherent long scan time of MRI restricts its widespread applicability. Deep learning-based image super-resolution (SR) methods…

Image and Video Processing · Electrical Eng. & Systems 2024-02-19 Hao Li , Quanwei Liu , Jianan Liu , Xiling Liu , Yanni Dong , Tao Huang , Zhihan Lv

Multi-site MRI studies often suffer from site-specific variations arising from differences in methodology, hardware, and acquisition protocols, thereby compromising accuracy and reliability in clinical AI/ML tasks. We present PRISM…

Image and Video Processing · Electrical Eng. & Systems 2024-11-12 Sarang Galada , Tanurima Halder , Kunal Deo , Ram P Krish , Kshitij Jadhav

Foundation models pretrained on large-scale datasets via self-supervised learning demonstrate exceptional versatility across various tasks. Due to the heterogeneity and hard-to-collect medical data, this approach is especially beneficial…

Computational Engineering, Finance, and Science · Computer Science 2024-03-05 Yanwu Yang , Chenfei Ye , Guinan Su , Ziyao Zhang , Zhikai Chang , Hairui Chen , Piu Chan , Yue Yu , Ting Ma

In Magnetic Resonance Imaging (MRI), image acquisitions are often undersampled in the measurement domain to accelerate the scanning process, at the expense of image quality. However, image quality is a crucial factor that influences the…

Image and Video Processing · Electrical Eng. & Systems 2024-05-31 Mevan Ekanayake , Zhifeng Chen , Mehrtash Harandi , Gary Egan , Zhaolin Chen

Demographic attributes such as age, sex, and race can be predicted from medical images, raising concerns about bias in clinical AI systems. In brain MRI, this signal may arise from anatomical variation, acquisition-dependent contrast…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Mehmet Yigit Avci , Akshit Achara , Andrew King , Jorge Cardoso

Clinical routine and retrospective cohorts commonly include multi-parametric Magnetic Resonance Imaging; however, they are mostly acquired in different anisotropic 2D views due to signal-to-noise-ratio and scan-time constraints. Thus…

Foundation models in artificial intelligence (AI) are transforming medical imaging by enabling general-purpose feature learning from large-scale, unlabeled datasets. In this work, we introduce BrainFound, a self-supervised foundation model…

Computer Vision and Pattern Recognition · Computer Science 2026-01-01 Moona Mazher , Geoff J. M. Parker , Daniel C. Alexander

The human brain is a complex system requiring both macroscopic and microscopic components for comprehensive understanding. However, mapping nonlinear relationships between these scales remains challenging due to technical limitations and…

Image and Video Processing · Electrical Eng. & Systems 2025-10-28 Sooyoung Kim , Joonwoo Kwon , Junbeom Kwon , Jungyoun Janice Min , Sangyoon Bae , Yuewei Lin , Shinjae Yoo , Jiook Cha

Machine Learning (ML) is increasingly being used for computer aided diagnosis of brain related disorders based on structural magnetic resonance imaging (MRI) data. Most of such work employs biologically and medically meaningful hand-crafted…

Machine Learning · Computer Science 2018-05-04 Ayush Jaiswal , Dong Guo , Cauligi S. Raghavendra , Paul Thompson

Homologous anatomical landmarks between medical scans are instrumental in quantitative assessment of image registration quality in various clinical applications, such as MRI-ultrasound registration for tissue shift correction in…

Computer Vision and Pattern Recognition · Computer Science 2023-07-28 Soorena Salari , Amirhossein Rasoulian , Hassan Rivaz , Yiming Xiao

Lesion detection in brain Magnetic Resonance Images (MRIs) remains a challenging task. MRIs are typically read and interpreted by domain experts, which is a tedious and time-consuming process. Recently, unsupervised anomaly detection (UAD)…

Image and Video Processing · Electrical Eng. & Systems 2022-02-01 Marcel Bengs , Finn Behrendt , Max-Heinrich Laves , Julia Krüger , Roland Opfer , Alexander Schlaefer

Surface-based analysis of the cerebral cortex is ubiquitous in human neuroimaging with MRI. It is crucial for cortical registration, parcellation, and thickness estimation. Traditionally, these analyses require high-resolution, isotropic…

Image and Video Processing · Electrical Eng. & Systems 2024-09-09 Karthik Gopinath , Douglas N. Greve , Colin Magdamo , Steve Arnold , Sudeshna Das , Oula Puonti , Juan Eugenio Iglesias

Medical images used in clinical practice are heterogeneous and not the same quality as scans studied in academic research. Preprocessing breaks down in extreme cases when anatomy, artifacts, or imaging parameters are unusual or protocols…

Image and Video Processing · Electrical Eng. & Systems 2022-08-31 Mostafa Mehdipour Ghazi , Mads Nielsen

Decoding visual representations from brain signals has attracted significant attention in both neuroscience and artificial intelligence. However, the degree to which brain signals truly encode visual information remains unclear. Current…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Jiawen Zheng , Haonan Jia , Ming Li , Yuhui Zheng , Yufeng Zeng , Yang Gao , Chen Liang

We present a keypoint-based foundation model for general purpose brain MRI registration, based on the recently-proposed KeyMorph framework. Our model, called BrainMorph, serves as a tool that supports multi-modal, pairwise, and scalable…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Alan Q. Wang , Rachit Saluja , Heejong Kim , Xinzi He , Adrian Dalca , Mert R. Sabuncu