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Objective: To (1) demonstrate the implementation of a data science platform built on open-source technology within a large, academic healthcare system and (2) describe two computational healthcare applications built on such a platform.…

Researchers in biomedical research, public health, and the life sciences often spend weeks or months discovering, accessing, curating, and integrating data from disparate sources, significantly delaying the onset of actual analysis and…

This is a thought piece on data-intensive science requirements for databases and science centers. It argues that peta-scale datasets will be housed by science centers that provide substantial storage and processing for scientists who access…

Databases · Computer Science 2007-05-23 Jim Gray , David T. Liu , Maria Nieto-Santisteban , Alexander S. Szalay , David DeWitt , Gerd Heber

Scientific data governance should prioritize maximizing the utility of data throughout the research lifecycle. Research software systems that enable analysis reproducibility inform data governance policies and assist administrators in…

Advances in technology and computing hardware are enabling scientists from all areas of science to produce massive amounts of data using large-scale simulations or observational facilities. In this era of data deluge, effective coordination…

Databases · Computer Science 2015-03-31 Spyros Blanas , Surendra Byna

Dynamo is a full-stack software solution for scientific data management. Dynamo's architecture is modular, extensible, and customizable, making the software suitable for managing data in a wide range of installation scales, from a few…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-05-18 Yutaro Iiyama , Benedikt Maier , Daniel Abercrombie , Maxim Goncharov , Christoph Paus

As data-driven methods are becoming pervasive in a wide variety of disciplines, there is an urgent need to develop scalable and sustainable tools to simplify the process of data science, to make it easier to keep track of the analyses being…

Databases · Computer Science 2016-10-18 Hui Miao , Amit Chavan , Amol Deshpande

We describe the current state and future plans for a set of tools for scientific data management (SDM) designed to support scientific transparency and reproducible research. SDM has been in active use at our MRI Center for more than two…

Quantitative Methods · Quantitative Biology 2015-02-25 B. A. Wandell , A. Rokem , L. M. Perry , G. Schaefer , R. F. Dougherty

The increasing volumes of data produced by high-throughput instruments coupled with advanced computational infrastructures for scientific computing have enabled what is often called a {\em Fourth Paradigm} for scientific research based on…

In this paper we describe the design, and implementation of the Open Science Data Cloud, or OSDC. The goal of the OSDC is to provide petabyte-scale data cloud infrastructure and related services for scientists working with large quantities…

Automated scientific discovery with large language models is transforming the research lifecycle from ideation to experimentation, yet existing agents struggle to autonomously process raw data collected from scientific experiments. We…

Artificial Intelligence · Computer Science 2026-04-29 Ke Lin , Yilin Lu , Shreyas Bhat , Xuehang Guo , Junier Oliva , Qingyun Wang

Increasingly massive volumes of multi-modal data are being accumulated in many {real world} settings, including in health care and e-commerce. This development calls for effective general-purpose data management solutions for multi-modal…

Databases · Computer Science 2025-07-08 Tang Qian , Yifan Zhu , Lu Chen , Xiangyu Ke , Jingwen Zhao , Tianyi Li , Yunjun Gao , Christian S. Jensen

In many sciences the increasing amounts of data are reaching the limit of established data handling and processing. With four large research centers of the German Helmholtz association the Large Scale Data Management and Analysis (LSDMA)…

The reuse of research software is central to research efficiency and academic exchange. The application of software enables researchers with varied backgrounds to reproduce, validate, and expand upon study findings. Furthermore, the…

Large systems biology projects can encompass several workgroups often located in different countries. An overview about existing data standards in systems biology and the management, storage, exchange and integration of the generated data…

Databases · Computer Science 2009-12-15 Gerhard Mayer

Modern biological research is increasingly data-intensive, leading to a growing demand for effective training in biological data science. In this article, we provide an overview of key resources and best practices available within the…

Scientists today collect, analyze, and generate TeraBytes and PetaBytes of data. These data are often shared and further processed and analyzed among collaborators. In order to facilitate sharing and data interpretations, data need to carry…

Instrumentation and Methods for Astrophysics · Physics 2010-05-18 Ewa Deelman , Bruce Berriman , Ann Chervenak , Oscar Corcho , Paul Groth , Luc Moreau

Fast, reliable, and efficient data transmission across wide-area networks is a predominant bottleneck for data-intensive cloud applications. This paper introduces OneDataShare, which is designed to eliminate the issues plaguing effective…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-12-11 Asif Imran , Md S Q Zulkar Nine , Kemal Guner , Tevfik Kosar

Background: Biomedical research projects deal with data management requirements from multiple sources like funding agencies' guidelines, publisher policies, discipline best practices, and their own users' needs. We describe functional and…

The increasingly collaborative, globalized nature of scientific research combined with the need to share data and the explosion in data volumes present an urgent need for a scientific data management system (SDMS). An SDMS presents a…

Databases · Computer Science 2020-04-09 Dale Stansberry , Suhas Somnath , Jessica Breet , Gregory Shutt , Mallikarjun Shankar
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