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We analyze an optimal control version of a simple SIR epidemiology model that includes a partially specified vaccination policy and takes into account fatigue from protracted application of social distancing measures. The model assumes…

Populations and Evolution · Quantitative Biology 2021-08-17 Evangelos F. Magirou

The main purpose of this paper is to study the local dynamics and bifurcations of a discrete-time SIR epidemiological model. The existence and stability of disease-free and endemic fixed points are investigated along with a fairly complete…

Dynamical Systems · Mathematics 2021-08-05 Johan Hallberg Szabadváry , Yishao Zhou

Compartmental transmission models have become an invaluable tool to study the dynamics of infectious diseases. The Susceptible-Infectious-Recovered (SIR) model is known to have an exact semi-analytical solution. In the current study, the…

Populations and Evolution · Quantitative Biology 2020-11-03 Kevin Heng , Christian L. Althaus

In contrast to the common assumption in epidemic models that the rate of infection between individuals is constant, in reality, an individual's viral load determines their infectiousness. We compare the average and individual reproductive…

Populations and Evolution · Quantitative Biology 2021-12-07 Nicholas Landry

Approximating the time to extinction of infection is an important problem in infection modelling. A variety of different approaches have been proposed in the literature. We study the performance of a number of such methods, and characterize…

Probability · Mathematics 2017-07-11 Damian Clancy , Elliott Tjia

We investigate an epidemic model based on Bailey's continuous differential system. In the continuous time domain, we extend the classical model to time-dependent coefficients and present an alternative solution method to Gleissner's…

Classical Analysis and ODEs · Mathematics 2019-01-01 Martin Bohner , Sabrina Streipert , Delfim F. M. Torres

The rapidly spreading Covid-19 that affected almost all countries, was first reported at the end of 2019. As a consequence of its highly infectious nature, countries all over the world have imposed extremely strict measures to control its…

Populations and Evolution · Quantitative Biology 2020-07-13 Semra Ahmetolan , Ayse Humeyra Bilge , Ali Demirci , Ayse Peker-Dobie , Onder Ergonul

Throughout human history, epidemics have been a constant presence. Understanding their dynamics is essential to predict scenarios and make substantiated decisions. Mathematical models are powerful tools to describe an epidemic behavior.…

Systems and Control · Electrical Eng. & Systems 2024-07-26 Walter HMendes aselein , Diego Eckhard

We propose and solve an optimal vaccination problem within a deterministic compartmental model of SIRS type: the immunized population can become susceptible again, e.g.\ because of a not complete immunization power of the vaccine. A social…

Optimization and Control · Mathematics 2022-06-08 Salvatore Federico , Giorgio Ferrari , Maria-Laura Torrente

Compartmental models, especially the Susceptible-Infected-Removed (SIR) model, have long been used to understand the behaviour of various diseases. Allowing parameters, such as the transmission rate, to be time-dependent functions makes it…

Methodology · Statistics 2024-09-27 Son Luu , Edward Susko , Lam Si Tung Ho

In this work, we review the figures used to characterize an epidemic outbreak most. Particular attention is drawn to epidemic spreading at time-varying transition rates. A time-varying SIR-like model is used to describe the epidemic…

Populations and Evolution · Quantitative Biology 2020-11-06 Hernán De Battista , José García-Clúa , Sebastián Nuñez , Fernando Inthamoussou , Fabricio Garelli

Understanding the dynamics of an epidemic spread is crucial for effective control measures. During the COVID-19 pandemic, quarantines were implemented to minimize infections while mitigating social and economic impacts, raising the question…

Statistical Mechanics · Physics 2024-11-19 Eyal Atias , Michael Assaf

This paper presents a vaccination-based control strategy for a SEIR (susceptible plus infected plus infectious plus removed populations) propagation disease model. The model takes into account the total population amounts as a refrain for…

Dynamical Systems · Mathematics 2011-03-28 M. De la Sen , A. Ibeas , S. Alonso-Quesada

In this work we study a modified Susceptible-Infected-Susceptible (SIS) model in which the infection rate $\lambda$ decays exponentially with the number of reinfections $n$, saturating after $n=l$. We find a critical decaying rate…

Physics and Society · Physics 2012-05-14 Nuno Crokidakis , Marcio Argollo de Menezes

In this study, we propose a time-dependent Susceptible-Exposed-Infected-Recovered (SEIR) model for the analysis of the SARS-CoV-2 epidemic outbreak in three different countries, the United States of America, Italy and Iceland using public…

Populations and Evolution · Quantitative Biology 2021-11-08 P. Girardi , C. Gaetan

Fractional-order SIR models have become increasingly popular in the literature in recent years, however unlike the standard SIR model, they often lack a derivation from an underlying stochastic process. Here we derive a fractional-order…

Populations and Evolution · Quantitative Biology 2016-03-31 Christopher N Angstmann , Bruce I Henry , Anna V McGann

The COVID-19 pandemic highlighted the need to improve the modeling, estimation, and prediction of how infectious diseases spread. SEIR-like models have been particularly successful in providing accurate short-term predictions. This study…

Populations and Evolution · Quantitative Biology 2024-12-31 Jorge P. Zubelli , Jennifer Loria , Vinicius V. L. Albani

In this paper, an SIR epidemic model with variable size of population is considered. We study optimal control problem for an SIR model with "vaccination" and "treatment" as controls. It is shown that an optimal control exists. We have…

Optimization and Control · Mathematics 2016-12-28 Olga Klimenkova

A generalisation of the Susceptible-Infectious model is made to include a time-dependent transmission rate, which leads to a close analytical expression in terms of a logistic function. The solution can be applied to any continuous function…

Physics and Society · Physics 2020-10-08 L. Arturo Urena-Lopez , Alma X. Gonzalez-Morales

This article is devoted to the analysis of a particle system model for epidemics among a finite population with susceptible, infective and removed individuals (SIR). The infection mechanism depends on the relative distance between…

Probability · Mathematics 2020-03-10 Monia Capanna