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Artificial intelligence holds great promise in medical imaging, especially histopathological imaging. However, artificial intelligence algorithms cannot fully explain the thought processes during decision-making. This situation has brought…

Image and Video Processing · Electrical Eng. & Systems 2022-08-04 Tuncay Yiğit , Nilgün Şengöz , Özlem Özmen , Jude Hemanth , Ali Hakan Işık

Objective. This paper presents an overview of generalizable and explainable artificial intelligence (XAI) in deep learning (DL) for medical imaging, aimed at addressing the urgent need for transparency and explainability in clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 Ahmad Chaddad , Yan Hu , Yihang Wu , Binbin Wen , Reem Kateb

Although deep neural networks hold the state-of-the-art in several remote sensing tasks, their black-box operation hinders the understanding of their decisions, concealing any bias and other shortcomings in datasets and model performance.…

Machine Learning · Computer Science 2021-09-21 Ioannis Kakogeorgiou , Konstantinos Karantzalos

The integration of artificial intelligence (AI) into medicine is remarkable, offering advanced diagnostic and therapeutic possibilities. However, the inherent opacity of complex AI models presents significant challenges to their clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Binbin Wen , Yihang Wu , Tareef Daqqaq , Ahmad Chaddad

In machine learning algorithm design, there exists a trade-off between the interpretability and performance of the algorithm. In general, algorithms which are simpler and easier for humans to comprehend tend to show worse performance than…

Machine Learning · Computer Science 2024-07-15 Eric M. Vernon , Naoki Masuyama , Yusuke Nojima

As the manufacturing industry advances with sensor integration and automation, the opaque nature of deep learning models in machine learning poses a significant challenge for fault detection and diagnosis. And despite the related predictive…

Artificial Intelligence · Computer Science 2024-06-11 Ahmed Maged , Salah Haridy , Herman Shen

Why do explainable AI (XAI) explanations in radiology, despite their promise of transparency, still fail to gain human trust? Current XAI approaches provide justification for predictions, however, these do not meet practitioners' needs.…

Human-Computer Interaction · Computer Science 2023-04-10 Robert Kaufman , David Kirsh

Explainable AI(XAI)is a domain focused on providing interpretability and explainability of a decision-making process. In the domain of law, in addition to system and data transparency, it also requires the (legal-) decision-model…

Human-Computer Interaction · Computer Science 2020-12-18 Lukasz Gorski , Shashishekar Ramakrishna , Jedrzej M. Nowosielski

The implementation of Artificial Intelligence (AI) systems in the manufacturing domain enables higher production efficiency, outstanding performance, and safer operations, leveraging powerful tools such as deep learning and reinforcement…

Artificial Intelligence · Computer Science 2021-07-07 Georgios Sofianidis , Jože M. Rožanec , Dunja Mladenić , Dimosthenis Kyriazis

The growing adoption of artificial intelligence in healthcare has raised concerns about the transparency and trustworthiness of AI-driven medical diagnosis systems. Many existing models operate as black boxes, limiting clinicians' ability…

Human-Computer Interaction · Computer Science 2026-04-21 Altynbek Seitenov , Ainur Nurzhanova , Azhar Bekbussinova , Yerassyl Bolatkan

The development of explainable artificial intelligence (xAI) methods for scene classification problems has attracted great attention in remote sensing (RS). Most xAI methods and the related evaluation metrics in RS are initially developed…

Computer Vision and Pattern Recognition · Computer Science 2025-10-23 Jonas Klotz , Tom Burgert , Begüm Demir

Machine learning technologies for protein function prediction are black box models. Despite their potential to identify key drug targets with high accuracy and accelerate therapy development, the adoption of these methods depends on…

Biomolecules · Quantitative Biology 2025-12-02 Ananya Krishna , Valentina Simon , Arjan Kohli

Artificial intelligence (AI) systems utilizing deep neural networks (DNNs) and machine learning (ML) algorithms are widely used for solving important problems in bioinformatics, biomedical informatics, and precision medicine. However,…

Quantitative Methods · Quantitative Biology 2023-02-24 Md. Rezaul Karim , Tanhim Islam , Oya Beyan , Christoph Lange , Michael Cochez , Dietrich Rebholz-Schuhmann , Stefan Decker

Counterfactual explanations have emerged as a popular solution for the eXplainable AI (XAI) problem of elucidating the predictions of black-box deep-learning systems due to their psychological validity, flexibility across problem domains…

Machine Learning · Computer Science 2022-12-20 Eoin Delaney , Arjun Pakrashi , Derek Greene , Mark T. Keane

We present an approach to explain the decisions of black box models for image classification. While using the black box to label images, our explanation method exploits the latent feature space learned through an adversarial autoencoder.…

Computer Vision and Pattern Recognition · Computer Science 2020-02-11 Riccardo Guidotti , Anna Monreale , Stan Matwin , Dino Pedreschi

Explainable AI (XAI) has been proposed as a valuable tool to assist in downstream tasks involving human and AI collaboration. Perhaps the most psychologically valid XAI techniques are case based approaches which display 'whole' exemplars to…

Artificial Intelligence · Computer Science 2023-11-07 Eoin Kenny , Eoin Delaney , Mark Keane

Explainable Artificial Intelligence (XAI) is a rising field in AI. It aims to produce a demonstrative factor of trust, which for human subjects is achieved through communicative means, which Machine Learning (ML) algorithms cannot solely…

Machine Learning · Computer Science 2021-03-09 Jamie Andrew Duell

As machine learning methods see greater adoption and implementation in high stakes applications such as medical image diagnosis, the need for model interpretability and explanation has become more critical. Classical approaches that assess…

Machine Learning · Computer Science 2020-02-12 Sumedha Singla , Brian Pollack , Junxiang Chen , Kayhan Batmanghelich

Convolutional neural networks (CNNs) are widely used for high-stakes applications like medicine, often surpassing human performance. However, most explanation methods rely on post-hoc attribution, approximating the decision-making process…

Machine Learning · Computer Science 2026-02-23 Kerol Djoumessi , Philipp Berens

Convolutional neural networks (CNNs) achieve prevailing results in segmentation tasks nowadays and represent the state-of-the-art for image-based analysis. However, the understanding of the accurate decision-making process of a CNN is…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Tillmann Rheude , Andreas Wirtz , Arjan Kuijper , Stefan Wesarg