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In this paper, a tractable methodology is proposed to approximate stochastic optimal feedback treatment in the context of mixed immuno-chemo therapy of cancer. The method uses a fixed-point value iteration that approximately solves a…

Systems and Control · Computer Science 2020-10-26 Mazen Alamir

A method for adaptive model order reduction for nonsmooth discrete element simulation is developed and analysed in numerical experiments. Regions of the granular media that collectively move as rigid bodies are substituted with rigid bodies…

Computational Physics · Physics 2015-12-02 Martin Servin , Da Wang

This study presents a novel approach to applying data assimilation techniques for particle-based simulations using the Ensemble Kalman Filter. While data assimilation methods have been effectively applied to Eulerian simulations, their…

Numerical Analysis · Mathematics 2024-12-10 Marius Duvillard , Loïc Giraldi , Olivier Le Maître

The theoretical analysis of many problems in physics, astronomy and applied mathematics requires an efficient numerical exploration of multimodal parameter spaces that exhibit broken ergodicity. Monte Carlo methods are widely used to deal…

Statistical Mechanics · Physics 2014-09-02 Stefano Martiniani , Jacob D. Stevenson , David J. Wales , Daan Frenkel

The force field describing the calculated interaction between atoms or molecules is the key to the accuracy of many molecular dynamics (MD) simulation results. Compared with traditional or semi-empirical force fields, machine learning force…

Computational Physics · Physics 2023-06-28 Yongle Li , Feng Xu , Long Hou , Luchao Sun , Haijun Su , Xi Li , Wei Ren

Diffusion policies are expressive yet incur high inference latency. Flow Matching (FM) enables one-step generation, but integrating it into Maximum Entropy Reinforcement Learning (MaxEnt RL) is challenging: the optimal policy is an…

Machine Learning · Computer Science 2026-02-03 Zeqiao Li , Yijing Wang , Haoyu Wang , Zheng Li , Zhiqiang Zuo

Kernel-based methods such as Rocket are among the most effective default approaches for univariate time series classification (TSC), yet they do not perform equally well across all datasets. We revisit the long-standing intuition that…

Machine Learning · Computer Science 2026-01-13 Honey Singh Chauhan , Zahraa S. Abdallah

Quantum error correction is widely thought to be the key to fault-tolerant quantum computation. However, determining the most suited encoding for unknown error channels or specific laboratory setups is highly challenging. Here, we present a…

Supervised fine-tuning (SFT) is crucial for adapting Large Language Models (LLMs) to specific tasks. In this work, we demonstrate that the order of training data can lead to significant training imbalances, potentially resulting in…

Computation and Language · Computer Science 2024-10-08 Yiming Ju , Ziyi Ni , Xingrun Xing , Zhixiong Zeng , hanyu Zhao , Siqi Fan , Zheng Zhang

Traditional reinforcement learning often struggles to generate diverse, high-reward solutions, especially in domains like drug design and black-box function optimization. Markov Chain Monte Carlo (MCMC) methods provide an alternative method…

Machine Learning · Computer Science 2024-10-02 Siyi He

Quadratic programming is a workhorse of modern nonlinear optimization, control, and data science. Although regularized methods offer convergence guarantees under minimal assumptions on the problem data, they can exhibit the slow…

Optimization and Control · Mathematics 2026-05-18 Jeremy Bertoncini , Alberto De Marchi , Matthias Gerdts , Simon Gottschalk

We propose a single-loop variance-reduced acceleration framework, which relates checkpoint update probabilities to momentum parameters, for solving the composite general convex problem where the smooth part has the finite-sum structure.…

Optimization and Control · Mathematics 2026-02-26 Hai Liu , Tiande Guo , Congying Han

This paper proposes a general optimization strategy, which combines results from different optimization or parameter estimation methods to overcome shortcomings of a single method. Shotgun optimization is developed as a framework which…

Computation · Statistics 2017-11-15 Biljana Jonoska Stojkova , David A. Campbell

In the quest for efficient and robust reinforcement learning methods, both model-free and model-based approaches offer advantages. In this paper we propose a new way of explicitly bridging both approaches via a shared low-dimensional…

Machine Learning · Computer Science 2018-11-20 Vincent François-Lavet , Yoshua Bengio , Doina Precup , Joelle Pineau

Efficient data compression is crucial for the storage and transmission of visual data. However, in facial expression recognition (FER) tasks, lossy compression often leads to feature degradation and reduced accuracy. To address these…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Xiumei Li , Marc Windsheimer , Misha Sadeghi , Björn Eskofier , André Kaup

The ensemble Kalman filter (EnKF) is an efficient algorithm for many data assimilation problems. In certain circumstances, however, divergence of the EnKF might be spotted. In previous studies, the authors proposed an…

Atmospheric and Oceanic Physics · Physics 2014-08-19 Xiaodong Luo , Ibrahim Hoteit

Optimizing data mixtures for supervised fine-tuning (SFT) of large language models (LLMs) is critical for developing general-purpose models, yet this area remains underexplored. In this paper, we frame data mixing as an optimization problem…

Artificial Intelligence · Computer Science 2025-08-19 Yuan Li , Zhengzhong Liu , Eric Xing

Calibrating agent-based models (ABMs) in economics and finance typically involves a derivative-free search in a very large parameter space. In this work, we benchmark a number of search methods in the calibration of a well-known…

Machine Learning · Computer Science 2023-12-08 Aldo Glielmo , Marco Favorito , Debmallya Chanda , Domenico Delli Gatti

We propose a novel method to optimize existing force-field parameters for protein systems. The method consists of minimizing the summation of the square of the force acting on each atom in the proteins with the structures from the Protein…

Statistical Mechanics · Physics 2009-11-10 Yoshitake Sakae , Yuko Okamoto

We present a method to probe rare molecular dynamics trajectories directly using reinforcement learning. We consider trajectories that are conditioned to transition between regions of configuration space in finite time, like those relevant…

Statistical Mechanics · Physics 2022-01-07 Avishek Das , Dominic C. Rose , Juan P. Garrahan , David T. Limmer
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